Inhibitory Investigations of Acyl-CoA Derivatives against Human Lipoxygenase Isozymes.
acyl-coenzyme A
inhibition
lipoxygenase
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Jun 2023
30 Jun 2023
Historique:
received:
05
06
2023
revised:
26
06
2023
accepted:
27
06
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Lipid metabolism is a complex process crucial for energy production resulting in high levels of acyl-coenzyme A (acyl-CoA) molecules in the cell. Acyl-CoAs have also been implicated in inflammation, which could be possibly linked to lipoxygenase (LOX) biochemistry by the observation that an acyl-CoA was bound to human platelet 12-lipoxygenase via cryo-EM. Given that LOX isozymes play a pivotal role in inflammation, a more thorough investigation of the inhibitory effects of acyl-CoAs on lipoxygenase isozymes was judged to be warranted. Subsequently, it was determined that C18 acyl-CoA derivatives were the most potent against h12-LOX, human reticulocyte 15-LOX-1 (h15-LOX-1), and human endothelial 15-LOX-2 (h15-LOX-2), while C16 acyl-CoAs were more potent against human 5-LOX. Specifically, oleoyl-CoA (18:1) was most potent against h12-LOX (IC
Identifiants
pubmed: 37446119
pii: ijms241310941
doi: 10.3390/ijms241310941
pmc: PMC10341549
pii:
doi:
Substances chimiques
Lipoxygenase
EC 1.13.11.12
Isoenzymes
0
Oxylipins
0
Acyl Coenzyme A
0
Scavenger Receptors, Class E
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : gm131835
Pays : United States
Références
Bioorg Med Chem. 2007 Dec 1;15(23):7408-25
pubmed: 17869117
Front Cell Neurosci. 2018 Jul 10;12:169
pubmed: 30050410
Horm Metab Res. 2021 Dec;53(12):771-778
pubmed: 34891207
Methods Enzymol. 1981;72:404-8
pubmed: 7311839
J Lipid Res. 2009 Apr;50 Suppl:S138-43
pubmed: 19047759
Chem Rev. 2011 Oct 12;111(10):5866-98
pubmed: 21936577
Front Pharmacol. 2022 Mar 02;13:838782
pubmed: 35308198
Molecules. 2022 Oct 19;27(20):
pubmed: 36296646
Biochemistry. 2019 Feb 12;58(6):848-857
pubmed: 30565457
Int J Mol Sci. 2020 May 04;21(9):
pubmed: 32375338
Trends Endocrinol Metab. 2021 May;32(5):320-332
pubmed: 33712368
Anal Biochem. 1980 Aug;106(2):344-50
pubmed: 7447002
Front Oncol. 2022 Mar 11;12:836058
pubmed: 35359351
Biochim Biophys Acta. 2015 Apr;1851(4):308-30
pubmed: 25316652
Biochemistry. 2003 May 13;42(18):5236-43
pubmed: 12731864
Curr Opin Cell Biol. 2015 Apr;33:125-31
pubmed: 25703630
Nat Rev Immunol. 2016 Jan;16(1):51-67
pubmed: 26688348
Prostaglandins Leukot Essent Fatty Acids. 2001 Jan;64(1):61-5
pubmed: 11161586
Hormones (Athens). 2018 Mar;17(1):61-67
pubmed: 29858856
Redox Biol. 2015 Dec;6:297-310
pubmed: 26298204
Biochemistry. 2013 Nov 12;52(45):8026-35
pubmed: 24171444
Genes Dev. 2018 Apr 1;32(7-8):463-465
pubmed: 29692354
Diabetes Metab J. 2015 Oct;39(5):353-62
pubmed: 26566492
Biochim Biophys Acta. 2010 Dec;1801(12):1260-73
pubmed: 20708099
Curr Top Membr. 2019;84:67-98
pubmed: 31610866
PLoS One. 2010 Nov 11;5(11):e15540
pubmed: 21085606
Trends Endocrinol Metab. 2022 Jun;33(6):409-423
pubmed: 35370062
Respir Res. 2021 Jul 14;22(1):204
pubmed: 34261470
J Nat Prod. 2003 Feb;66(2):230-5
pubmed: 12608855
World J Diabetes. 2010 Jul 15;1(3):76-88
pubmed: 21537431