The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO).


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
06 Jul 2023
Historique:
received: 09 05 2023
revised: 25 06 2023
accepted: 28 06 2023
medline: 17 7 2023
pubmed: 14 7 2023
entrez: 14 7 2023
Statut: epublish

Résumé

Early stages are under-represented in studies on the molecular and immune features of high-grade serous ovarian carcinoma (HGSOC), and specific studies focused on early-stage HGSOC are required for a better prognostic stratification and to personalize chemotherapy. The aim of this study was to determine the prognostic significance of CD8+ and CD4+ tumor-infiltrating lymphocytes (TILs), tumoral cell PD-L1 expression,

Identifiants

pubmed: 37446361
pii: ijms241311183
doi: 10.3390/ijms241311183
pmc: PMC10342764
pii:
doi:

Substances chimiques

B7-H1 Antigen 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Instituto de Salud Carlos III
ID : PI19/01331
Organisme : Instituto de Salud Carlos III
ID : PI22/01892
Organisme : Instituto de Salud Carlos III
ID : PMP22/00054
Organisme : Centro de Investigación Biomédica en Red de Cáncer
ID : CB16/12/00316
Organisme : Spanish Ovarian Cancer Research Group
ID : NA
Organisme : Asociación Española Contra el Cáncer
ID : NA

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Auteurs

David Pizarro (D)

Pathology Department, University Hospital Ramón y Cajal, IRYCIS, 28034 Madrid, Spain.

Ignacio Romero (I)

Instituto Valenciano de Oncología, 46009 Valencia, Spain.
Spanish Group for Investigation on Ovarian Cancer (GEICO), 28003 Madrid, Spain.

Belén Pérez-Mies (B)

Pathology Department, University Hospital Ramón y Cajal, IRYCIS, 28034 Madrid, Spain.
Biomedical Research Network in Oncology (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Faculty of Medicine, University of Alcalá, 28801 Alcalá de Henares, Spain.

Andrés Redondo (A)

Spanish Group for Investigation on Ovarian Cancer (GEICO), 28003 Madrid, Spain.
Oncology Department, University Hospital La Paz, IdiPAZ, 28046 Madrid, Spain.
Instituto de Investigación Sanitaria del Hospital Universitario La Paz, 28029 Madrid, Spain.
Faculty of Medicine, Autonomous University of Madrid, 28029 Madrid, Spain.

Tamara Caniego-Casas (T)

Pathology Department, University Hospital Ramón y Cajal, IRYCIS, 28034 Madrid, Spain.
Biomedical Research Network in Oncology (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, Spain.

Irene Carretero-Barrio (I)

Pathology Department, University Hospital Ramón y Cajal, IRYCIS, 28034 Madrid, Spain.
Biomedical Research Network in Oncology (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Faculty of Medicine, University of Alcalá, 28801 Alcalá de Henares, Spain.

Eva Cristóbal (E)

Biomedical Research Network in Oncology (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, Spain.

Ana Gutiérrez-Pecharromán (A)

Pathology Department, University Hospital Getafe, 28905 Getafe, Spain.

Ana Santaballa (A)

Spanish Group for Investigation on Ovarian Cancer (GEICO), 28003 Madrid, Spain.
Oncology Department, University Hospital La Fe, 46026 Valencia, Spain.

Emanuela D'Angelo (E)

Department of Medical, Oral, and Biotechnological Sciences, University "G.D'Annunzio" of Chieti-Pescara, 66013 Chieti, Italy.

David Hardisson (D)

Biomedical Research Network in Oncology (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Instituto de Investigación Sanitaria del Hospital Universitario La Paz, 28029 Madrid, Spain.
Faculty of Medicine, Autonomous University of Madrid, 28029 Madrid, Spain.
Pathology Department, University Hospital La Paz, 28046 Madrid, Spain.

Begoña Vieites (B)

Pathology Department, University Hospital Virgen del Rocío, 41013 Sevilla, Spain.

Xavier Matías-Guiu (X)

Biomedical Research Network in Oncology (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Pathology and Medical Oncology Departments, Hospital Universitari Arnau de Vilanova, IRBLLEIDA, University of Lleida, 25003 Lleida, Spain.
Pathology Department, Hospital Universitari de Bellvitge, IDIBELL, University of Barcelona, 08007 Barcelona, Spain.

Purificación Estévez (P)

Spanish Group for Investigation on Ovarian Cancer (GEICO), 28003 Madrid, Spain.
Oncology Department, University Hospital Virgen del Rocío, 41013 Sevilla, Spain.
Seville Biomedical Research Institute (IBIS), 41013 Sevilla, Spain.

Eva Guerra (E)

Spanish Group for Investigation on Ovarian Cancer (GEICO), 28003 Madrid, Spain.
Oncology Department, University Hospital Ramón y Cajal, IRYCIS, 28034 Madrid, Spain.

Jaime Prat (J)

Pathology Department, Emeritus Faculty, Autonomous University of Barcelona, 08193 Barcelona, Spain.

Andrés Poveda (A)

Spanish Group for Investigation on Ovarian Cancer (GEICO), 28003 Madrid, Spain.
Initia Oncología, Hospital Quironsalud Valencia, 46010 Valencia, Spain.

José Antonio López-Guerrero (JA)

Instituto Valenciano de Oncología, 46009 Valencia, Spain.
Spanish Group for Investigation on Ovarian Cancer (GEICO), 28003 Madrid, Spain.

José Palacios (J)

Pathology Department, University Hospital Ramón y Cajal, IRYCIS, 28034 Madrid, Spain.
Spanish Group for Investigation on Ovarian Cancer (GEICO), 28003 Madrid, Spain.
Biomedical Research Network in Oncology (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Faculty of Medicine, University of Alcalá, 28801 Alcalá de Henares, Spain.

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Classifications MeSH