Mechanochemical Studies on Coupling of Hydrazines and Hydrazine Amides with Phenolic and Furanyl Aldehydes-Hydrazones with Antileishmanial and Antibacterial Activities.
anti-infectious
antibacterial
antileishmanial
furanyls
hydrazones
mechanochemistry
phenolics
sustainable synthesis
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
07 Jul 2023
07 Jul 2023
Historique:
received:
07
06
2023
revised:
22
06
2023
accepted:
26
06
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Hydrazone compounds represent an important area of research that includes, among others, synthetic approaches and biological studies. A series of 17 hydrazones have been synthesized by mechanochemical means. The fragments chosen were phenolic and furanyl aldehydes coupled with 12 heterocyclic hydrazines or hydrazinamides. All compounds can be obtained quantitatively when operating on a planetary ball mill and a maximum reaction time of 180 min (6 cycles of 30 min each). Complete spectroscopic analyses of hydrazones revealed eight compounds (
Identifiants
pubmed: 37446945
pii: molecules28135284
doi: 10.3390/molecules28135284
pmc: PMC10343660
pii:
doi:
Substances chimiques
hydrazine
27RFH0GB4R
Hydrazones
0
Aldehydes
0
Amides
0
Hydrazines
0
Anti-Bacterial Agents
0
Antiprotozoal Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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