Stingless Bee (
KEAP1-NRF2 signalling
oxidative stress
phenolic-rich extract
stingless bee honey
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
22 Jun 2023
22 Jun 2023
Historique:
received:
30
05
2023
revised:
14
06
2023
accepted:
20
06
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Diabetes is associated with an imbalance between oxidants and antioxidants, leading to oxidative stress. This imbalance contributes to the development and progression of diabetic complications. Similarly, renal and liver diseases are characterised by oxidative stress, where an excess of oxidants overwhelms the antioxidant defense mechanisms, causing tissue damage and dysfunction. Restoring the oxidant-antioxidant balance is essential for mitigating oxidative stress-related damage under these conditions. In this current study, the efficacy of stingless bee honey (SBH) and its phenolic-rich extract (PRE) in controlling the oxidant-antioxidant balance in high-fat diet- and streptozotocin/nicotinamide-induced diabetic rats was investigated. The administration of SBH and PRE improved systemic antioxidant defense and oxidative stress-related measures without compromising liver and renal functioning. Analyses of the liver, skeletal muscle and adipose tissues revealed differences in their capacities to scavenge free radicals and halt lipid peroxidation. Transcriptional alterations hypothesised tissue-specific control of KEAP1-NRF2 signalling by upregulation of
Identifiants
pubmed: 37447162
pii: nu15132835
doi: 10.3390/nu15132835
pmc: PMC10343317
pii:
doi:
Substances chimiques
Antioxidants
0
NF-E2-Related Factor 2
0
Oxidants
0
Kelch-Like ECH-Associated Protein 1
0
Phenols
0
KEAP1 protein, rat
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education
ID : TRGS/1/2016/UPM/01/5/4
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