Alcohol, White Adipose Tissue, and Brown Adipose Tissue: Mechanistic Links to Lipogenesis and Lipolysis.
adipose tissue
alcohol
alcoholic liver disease
lipogenesis
lipolysis
liver
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
29 Jun 2023
29 Jun 2023
Historique:
received:
14
05
2023
revised:
21
06
2023
accepted:
27
06
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
According to data from the World Health Organization, there were about 3 million deaths caused by alcohol consumption worldwide in 2016, of which about 50% were related to liver disease. Alcohol consumption interfering with the normal function of adipocytes has an important impact on the pathogenesis of alcoholic liver disease. There has been increasing recognition of the crucial role of adipose tissue in regulating systemic metabolism, far beyond that of an inert energy storage organ in recent years. The endocrine function of adipose tissue is widely recognized, and the significance of the proteins it produces and releases is still being investigated. Alcohol consumption may affect white adipose tissue (WAT) and brown adipose tissue (BAT), which interact with surrounding tissues such as the liver and intestines. This review briefly introduces the basic concept and classification of adipose tissue and summarizes the mechanism of alcohol affecting lipolysis and lipogenesis in WAT and BAT. The adipose tissue-liver axis is crucial in maintaining lipid homeostasis within the body. Therefore, this review also demonstrates the effects of alcohol consumption on the adipose tissue-liver axis to explore the role of alcohol consumption in the crosstalk between adipose tissue and the liver.
Identifiants
pubmed: 37447280
pii: nu15132953
doi: 10.3390/nu15132953
pmc: PMC10346806
pii:
doi:
Substances chimiques
Ethanol
3K9958V90M
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Cultivation Project of Double First-Class Disciplines of Food Science and Engineering, Beijing Technology & Business University
ID : Nos. BTBUKF202201, BTBUYXTD202207
Organisme : Discipline Construction-Food Science and Engineering
ID : No. SPKX-202204
Organisme : Opening Project of Key Laboratory of Trace Element and Nutrition, National Health Commission of the People's Republic of China
ID : No. wlkfz202205
Organisme : Research Foundation for Youth Scholars of Beijing Technology and Business University
ID : No. QNJJ2022-06
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