Formononetin, a Beer Polyphenol with Catabolic Effects on Chondrocytes.
growth plate
osteoarthritis
phytoestrogens
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
29 Jun 2023
29 Jun 2023
Historique:
received:
02
06
2023
revised:
26
06
2023
accepted:
27
06
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Beer consumption has been identified as a risk factor for osteoarthritis (OA), a rheumatic disease characterised by cartilage degradation, joint inflammation, and eventual joint failure. One of the main isoflavonoids in beer is formononetin (FNT), an estrogenic compound also found in multiple plants and herbs. In this study, we aimed to investigate the effect of FNT on chondrocyte viability, inflammation, and metabolism. Cells were treated with FNT with or without IL-1β for 48 h and during 7 days of differentiation. Cell viability was determined via MTT assay. Nitrite accumulation was determined by Griess reaction. The expression of genes involved in inflammation and metabolism was determined by RT-PCR. The results revealed that a low concentration of FNT had no deleterious effect on cell viability and decreased the expression of inflammation-related genes. However, our results suggest that FNT overexposure negatively impacts on chondrocytes by promoting catabolic responses. Finally, these effects were not mediated by estrogen receptors (ERs) or aryl hydrocarbon receptor (AhR). In conclusion, factors that favour FNT accumulation, such as long exposure times or metabolic disorders, can promote chondrocyte catabolism. These data may partially explain why beer consumption increases the risk of OA.
Identifiants
pubmed: 37447284
pii: nu15132959
doi: 10.3390/nu15132959
pmc: PMC10346251
pii:
doi:
Substances chimiques
formononetin
295DQC67BJ
Polyphenols
0
Receptors, Estrogen
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto de Salud Carlos III
ID : PT20/00009, FI20/00210, CM20/00186, RD21/0002/0025, PI19/01446, PI16/01870, CPII20/00026, CP15/00007
Organisme : Spanish Ministry of Science
ID : PRECIPITA PR250
Organisme : Mutua Madrileña Foundation
ID : MMA 2018 & MMA 2020
Organisme : Spanish Ministry of Universities
ID : FPU17/01706 & UDC Margarita Salas RSU.UDC.MS06
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