Pharmacokinetic Analyses of Liposomal and Non-Liposomal Multivitamin/Mineral Formulations.
bioavailability
calcium
iron
magnesium
nutrient absorption
vitamin A
vitamin B12
vitamin C
vitamin E
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
07 Jul 2023
07 Jul 2023
Historique:
received:
14
04
2023
revised:
28
06
2023
accepted:
06
07
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Recent research supports previous contentions that encapsulating vitamins and minerals with liposomes help improve overall bioavailability. This study examined whether ingesting a liposomal multivitamin and mineral supplement (MVM) differentially affects the appearance and/or clearance of vitamins and minerals in the blood compared to a non-liposomal MVM supplement. In a double-blind, randomized, and counterbalanced manner, 34 healthy men and women fasted for 12 h. Then, they ingested a non-liposomal (NL) or liposomal (L) MVM supplement and a standardized snack. Venous blood samples were obtained at 0, 2, 4, and 6 h after MVM ingestion and analyzed for a panel of vitamins and minerals. Plasma levels of vitamins and minerals and mean changes from baseline with 95% confidence intervals (CIs) were analyzed using general linear model statistics with repeated measures. The observed values were also entered into pharmacokinetic analysis software and analyzed through univariate analysis of variance with repeated measure contrasts. The results revealed an overall treatment x time interaction effect among the vitamins and minerals evaluated (
Identifiants
pubmed: 37447400
pii: nu15133073
doi: 10.3390/nu15133073
pmc: PMC10347199
pii:
doi:
Substances chimiques
Iron
E1UOL152H7
Liposomes
0
Minerals
0
Vitamin A
11103-57-4
Vitamin E
1406-18-4
Vitamin K
12001-79-5
Vitamins
0
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Nutraceutical Corporation (Salt Lake City, UT, USA)
ID : 410661-00001
Références
Pharm Res. 2001 Mar;18(3):316-22
pubmed: 11442271
Adv Colloid Interface Sci. 2022 Sep;307:102750
pubmed: 35987014
J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25;824(1-2):132-8
pubmed: 16046288
J Int Soc Sports Nutr. 2018 Aug 1;15(1):38
pubmed: 30068354
Nutr Cancer. 2018 Nov-Dec;70(8):1184-1198
pubmed: 30741011
Clin Chim Acta. 2001 Apr;306(1-2):139-43
pubmed: 11282105
J Pharm Pharmacol. 2009 Apr;61(4):445-9
pubmed: 19298690
JAMA. 2022 Jun 21;327(23):2326-2333
pubmed: 35727271
Drug Des Devel Ther. 2016 Jan 12;10:205-15
pubmed: 26834457
J Liposome Res. 2020 Sep;30(3):227-234
pubmed: 31264495
Nutrients. 2021 Dec 20;13(12):
pubmed: 34960106
Amino Acids. 2011 May;40(5):1369-83
pubmed: 21424716
Colloids Surf B Biointerfaces. 2012 Jan 1;89:93-100
pubmed: 21962853
Nutr Metab Insights. 2016 Jun 20;9:25-30
pubmed: 27375360
Am J Clin Nutr. 1981 Mar;34(3):362-6
pubmed: 6259925
J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Sep 1;878(25):2339-47
pubmed: 20696624
Nutrients. 2022 Feb 28;14(5):
pubmed: 35268011
Clin Ther. 2018 Apr;40(4):640-657
pubmed: 29573851
Pharmaceuticals (Basel). 2018 May 27;11(2):
pubmed: 29861484
RSC Adv. 2021 Nov 26;11(60):38161-38171
pubmed: 35498071
Int J Mol Sci. 2021 Mar 16;22(6):
pubmed: 33809762
Adv Drug Deliv Rev. 2020;154-155:245-273
pubmed: 32473991
Nutrients. 2022 Aug 13;14(16):
pubmed: 36014827
J Biomed Nanotechnol. 2022 Mar 1;18(3):922-927
pubmed: 35715901
Biomacromolecules. 2014 Jan 13;15(1):350-60
pubmed: 24283460
Nutrients. 2019 May 07;11(5):
pubmed: 31067745
Nanomaterials (Basel). 2020 Nov 09;10(11):
pubmed: 33182343
Nanoscale Res Lett. 2013 Feb 22;8(1):102
pubmed: 23432972
Behav Brain Sci. 2017 Oct 25;41:e120
pubmed: 29065933
Nature. 2020 Mar;579(7798):190-192
pubmed: 32157231
Int J Sports Phys Ther. 2014 Oct;9(5):726-36
pubmed: 25328834
Transl Anim Sci. 2019 Mar 16;3(2):692-708
pubmed: 32704837
Nanomedicine. 2022 Jul;43:102552
pubmed: 35346834
Artif Cells Nanomed Biotechnol. 2017 Jun;45(4):788-799
pubmed: 28278586
Drug Deliv Transl Res. 2022 Nov;12(11):2856-2864
pubmed: 35322372
J Liposome Res. 2021 Dec;31(4):356-364
pubmed: 32901526
Artif Cells Nanomed Biotechnol. 2016;44(1):381-91
pubmed: 25222036
ACS Pharmacol Transl Sci. 2021 Jun 01;4(3):1028-1049
pubmed: 34151199
J Food Sci Technol. 2020 Oct;57(10):3545-3555
pubmed: 32903987
Mater Sci Eng C Mater Biol Appl. 2021 Feb;121:111851
pubmed: 33579485
Int J Vitam Nutr Res. 2004 Nov;74(6):453-61
pubmed: 15743021
Nanomaterials (Basel). 2022 Jun 30;12(13):
pubmed: 35808096
J Liposome Res. 2019 Jun;29(2):142-152
pubmed: 30187807