Fabrication and Applications of Potentiometric Membrane Sensors Based on γ-Cyclodextrin and Calixarene as Ionophores for the Determination of a Histamine H1-Receptor Antagonist: Fexofenadine.
drug formulation and quality control
fexofenadine
potentiometry
sensors
supramolecular chemistry
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
25 Jun 2023
25 Jun 2023
Historique:
received:
05
05
2023
revised:
18
06
2023
accepted:
22
06
2023
medline:
14
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Supramolecular fexofenadine sensors have been constructed. Although noncovalent intermolecular and intramolecular interactions, which are far weaker than covalent contacts, are the main focus of supramolecular chemistry, they can be used to create sensors with an exceptional affinity for a target analyte. The objective of the current research study is to adapt two PVC membrane sensors into an electrochemical approach for the dosage form determination of histamine H1-receptor antagonists: fexofenadine. The general performance characteristics of two new modified potentiometric membrane sensors responsive to fexofenadine hydrochloride were established. The technique was based on the employment of γ-cyclodextrin (CD) (sensor 1), 4-tert-butylcalix[8]arene (calixarene) (sensor 2) as an ionophore, potassium tetrakis (4-chlorophenyl) borate (KTpClPB) as an ion additive, and (
Identifiants
pubmed: 37447454
pii: polym15132808
doi: 10.3390/polym15132808
pmc: PMC10346524
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia
ID : IFKSUOR3-121-1
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