Cochlear implantation impairs intracochlear microcirculation and counteracts iNOS induction in guinea pigs.
cochlea implantation
cochlear microcirculation
hearing preservation
iNOS
microvascular permeability
nitric oxide
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2023
2023
Historique:
received:
20
03
2023
accepted:
06
06
2023
medline:
14
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Preservation of residual hearing remains a great challenge during cochlear implantation. Cochlear implant (CI) electrode array insertion induces changes in the microvasculature as well as nitric oxide (NO)-dependent vessel dysfunction which have been identified as possible mediators of residual hearing loss after cochlear implantation. A total of 24 guinea pigs were randomized to receive either a CI ( The sham control group showed no change in mean CBF after 1 h (104.2 ± 0.7%) and 2 h (100.8 ± 3.6%) compared to baseline. In contrast, cochlear implantation resulted in a significant continuous decrease in CBF after 1 h (78.8 ± 8.1%, Mechanical and NO-dependent microvascular dysfunction seem to play a pivotal role in residual hearing loss after CI electrode array insertion. This may be facilitated by the implantation associated decrease in iNOS expression. Therefore, stabilization of cochlear microcirculation could be a therapeutic strategy to preserve residual hearing.
Identifiants
pubmed: 37448696
doi: 10.3389/fncel.2023.1189980
pmc: PMC10336219
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1189980Informations de copyright
Copyright © 2023 Ernst, Heinrich, Fries, Meuser, Rader, Eckrich, Stauber and Strieth.
Déclaration de conflit d'intérêts
This study received funding from MED-EL GmbH in the form of guinea pig-specific cochlear implant electrode arrays. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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