Do magnetic resonance imaging features differ between persons with multiple sclerosis of various races and ethnicities?
African American
Latin American
ethnicity
magnetic resonance imaging
multiple sclerosis
neuroimaging
race
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
05
2023
accepted:
12
06
2023
medline:
14
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Those of African American or Latin American descent have been demonstrated to have more severe clinical presentations of multiple sclerosis (MS) than non-Latin American White people with MS. Concurrently, radiological burden of disease on magnetic resonance imaging (MRI) in African Americans with MS has also been described as being more aggressive. Here, we review MRI studies in diverse racial and ethnic groups (adult and pediatric) investigating lesion burden, inflammation, neurodegeneration, and imaging response to disease modifying therapy. We also discuss why such disparities may exist beyond biology, and how future studies may provide greater insights into underlying differences.
Identifiants
pubmed: 37448745
doi: 10.3389/fneur.2023.1215774
pmc: PMC10338060
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1215774Subventions
Organisme : NIA NIH HHS
ID : U54 AG044170
Pays : United States
Informations de copyright
Copyright © 2023 Nathoo, Zeydan, Neyal, Chelf, Okuda and Kantarci.
Déclaration de conflit d'intérêts
DO received personal compensation for consulting and advisory services from Alexion, Biogen, Celgene/Bristol Myers Squibb, EMD Serono, Genentech, Genzyme, Janssen Pharmaceuticals, Novartis, Osmotica Pharmaceuticals, RVL Pharmaceuticals, Inc., TG Therapeutics, and research support from Biogen, Novartis, and EMD Serono/Merck. DO has issued national and international patents along with pending patents related to other developed technologies. DO received royalties for intellectual property licensed by The Board of Regents of The University of Texas System. BZ receives research funding from the NIH (U54 AG044170) and is supported by the Mayo Clinic Eugene and Marcia Applebaum Award. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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