Origin of Osteoclasts: Osteoclast Precursor Cells.

Osteoclast precursor cells Osteoclast pregenitor Osteoclasts

Journal

Journal of bone metabolism
ISSN: 2287-6375
Titre abrégé: J Bone Metab
Pays: Korea (South)
ID NLM: 101599927

Informations de publication

Date de publication:
May 2023
Historique:
received: 13 03 2023
accepted: 27 04 2023
medline: 14 7 2023
pubmed: 14 7 2023
entrez: 14 7 2023
Statut: ppublish

Résumé

Osteoclasts are multinucleated bone-resorbing cells and a key player in bone remodeling for health and disease. Since the discovery of osteoclasts in 1873, the structure and function of osteoclasts and the molecular and cellular mechanisms of osteoclastogenesis have been extensively studied. Moreover, it has been well established that osteoclasts are differentiated in vitro from myeloid cells such as bone marrow macrophages or monocytes. The concept showing that osteoclasts are derived from a specific population (named osteoclast precursor cells [OCPs]) among myeloid cells has been long hypothesized. However, the specific precursor population of osteoclasts is not clearly defined yet. A growing body of work provides evidence of the developmental origin and lifespan of murine osteoclasts, particularly in vivo. Here, we review the emerging evidence that supports the existence of OCPs and discuss current insights into their identity.

Identifiants

pubmed: 37449346
pii: jbm.2023.30.2.127
doi: 10.11005/jbm.2023.30.2.127
pmc: PMC10346003
doi:

Types de publication

Journal Article

Langues

eng

Pagination

127-140

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Auteurs

Jefferson Tsai (J)

Arthritis and Tissue Degeneration Program, David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.

Kaichi Kaneko (K)

Division of Rheumatology, Department of Internal Medicine, Toho University Sakura Medical Center, Chiba, Japan.

Andrew J Suh (AJ)

Arthritis and Tissue Degeneration Program, David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.

Richard Bockman (R)

Division of Endocrinology and Metabolism, Hospital for Special Surgery, New York, NY, USA.
Department of Medicine, Weill Cornell Medical College, New York, NY, USA.

Kyung-Hyun Park-Min (KH)

Arthritis and Tissue Degeneration Program, David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.
Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
BCMB Allied Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.

Classifications MeSH