The importance of laminin at the blood-brain barrier.
astrocytes
basement membrane
blood vessels
blood-brain barrier integrity
dystroglycan
endothelial cells
inflammation
integrins
laminin
pericytes
Journal
Neural regeneration research
ISSN: 1673-5374
Titre abrégé: Neural Regen Res
Pays: India
ID NLM: 101316351
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
medline:
14
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
ppublish
Résumé
The blood-brain barrier is a unique property of central nervous system blood vessels that protects sensitive central nervous system cells from potentially harmful blood components. The mechanistic basis of this barrier is found at multiple levels, including the adherens and tight junction proteins that tightly bind adjacent endothelial cells and the influence of neighboring pericytes, microglia, and astrocyte endfeet. In addition, extracellular matrix components of the vascular basement membrane play a critical role in establishing and maintaining blood-brain barrier integrity, not only by providing an adhesive substrate for blood-brain barrier cells to adhere to, but also by providing guidance cues that strongly influence vascular cell behavior. The extracellular matrix protein laminin is one of the most abundant components of the basement membrane, and several lines of evidence suggest that it plays a key role in directing blood-brain barrier behavior. In this review, we describe the basic structure of laminin and its receptors, the expression patterns of these molecules in central nervous system blood vessels and how they are altered in disease states, and most importantly, how genetic deletion of different laminin isoforms or their receptors reveals the contribution of these molecules to blood-brain barrier function and integrity. Finally, we discuss some of the important unanswered questions in the field and provide a "to-do" list of some of the critical outstanding experiments.
Identifiants
pubmed: 37449589
pii: NeuralRegenRes_2023_18_12_2557_373677
doi: 10.4103/1673-5374.373677
pmc: PMC10358660
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
2557-2563Subventions
Organisme : NINDS NIH HHS
ID : R01 NS103966
Pays : United States
Déclaration de conflit d'intérêts
None
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