Bone health and body composition in transgender adults before gender-affirming hormonal therapy: data from the COMET study.
Body composition
Bone metabolism
Fat mass
Lean mass
Transgender
Journal
Journal of endocrinological investigation
ISSN: 1720-8386
Titre abrégé: J Endocrinol Invest
Pays: Italy
ID NLM: 7806594
Informations de publication
Date de publication:
14 Jul 2023
14 Jul 2023
Historique:
received:
28
04
2023
accepted:
05
07
2023
medline:
14
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
aheadofprint
Résumé
Preliminary data suggested that bone mineral density (BMD) in transgender adults before initiating gender-affirming hormone therapy (GAHT) is lower when compared to cisgender controls. In this study, we analyzed bone metabolism in a sample of transgender adults before GAHT, and its possible correlation with biochemical profile, body composition and lifestyle habits (i.e., tobacco smoke and physical activity). Medical data, smoking habits, phospho-calcic and hormonal blood tests and densitometric parameters were collected in a sample of 125 transgender adults, 78 Assigned Females At Birth (AFAB) and 47 Assigned Males At Birth (AMAB) before GAHT initiation and 146 cisgender controls (57 females and 89 males) matched by sex assigned at birth and age. 55 transgender and 46 cisgender controls also underwent a complete body composition evaluation and assessment of physical activity using the International Physical Activity Questionnaire (IPAQ). 14.3% of transgender and 6.2% of cisgender sample, respectively, had z-score values < -2 (p = 0.04). We observed only lower vitamin D values in transgender sample regarding biochemical/hormonal profile. AFAB transgender people had more total fat mass, while AMAB transgender individuals had reduced total lean mass as compared to cisgender people (53.94 ± 7.74 vs 58.38 ± 6.91, p < 0.05). AFAB transgender adults were more likely to be active smokers and tend to spend more time indoor. Fat Mass Index (FMI) was correlated with lumbar and femur BMD both in transgender individuals, while no correlations were found between lean mass parameters and BMD in AMAB transgender people. Body composition and lifestyle factors could contribute to low BMD in transgender adults before GAHT.
Identifiants
pubmed: 37450195
doi: 10.1007/s40618-023-02156-7
pii: 10.1007/s40618-023-02156-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Andrea Garolla
(A)
Anna Aprile
(A)
Bruno Azzena
(B)
Camillo Barbisan
(C)
Valentina Camozzi
(V)
Elena Campello
(E)
Cattelan Annamaria
(C)
Chiara Ceolin
(C)
Fabrizio Moro
(F)
Giorgio Conti
(G)
Angela Favaro
(A)
Alberto Ferlin
(A)
Francesco Francini
(F)
Michela Gatta
(M)
Marta Ghisi
(M)
Sandro Giannini
(S)
Laura Guazzarotti
(L)
Massimo Iafrate
(M)
Paolo Meneguzzo
(P)
Marina Miscioscia
(M)
Giancarlo Ottaviano
(G)
Carlo Saccardi
(C)
Lolita Sasset
(L)
Alberto Scala
(A)
Rossana Schiavo
(R)
Giuseppe Sergi
(G)
Paolo Simioni
(P)
Benedetta Tascini
(B)
Francesca Venturini
(F)
Fabrizio Vianello
(F)
Informations de copyright
© 2023. The Author(s).
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