Treatment with sofosbuvir attenuates the adverse neurodevelopmental consequences of Zika virus infection in infant rhesus macaques.

Animals Zika Virus Infection / complications Zika Virus Macaca mulatta Sofosbuvir / therapeutic use Antiviral Agents / therapeutic use
Antiviral Cognitive function Emotional reactivity Motor function Prophylaxis Social behavior

Journal

Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498

Informations de publication

Date de publication:
15 08 2023
Historique:
received: 22 04 2023
revised: 25 06 2023
accepted: 06 07 2023
pmc-release: 15 08 2024
medline: 16 8 2023
pubmed: 15 7 2023
entrez: 14 7 2023
Statut: ppublish

Résumé

Zika virus (ZIKV) infection during infancy in a rhesus macaque (RM) model negatively impacts brain development resulting in long-term behavioral alterations. The current study investigated whether postexposure prophylaxis could alleviate these negative neurodevelopmental consequences. Three RM infants received a 14-day course of sofosbuvir (SOF; 15 mg/kg p.o.) treatment starting at 3 days post-infection with a Puerto Rican strain of ZIKV (PRVABC59) and were then monitored longitudinally for one year. In contrast to ZIKV-infected infant RMs who did not receive SOF, postexposure SOF treatment mitigated the neurodevelopmental, behavioral and cognitive changes seen after postnatal ZIKV infection even while not accelerating viral clearance from the blood. These data suggest that antiviral treatment may help ameliorate some, but not all, of the neurodevelopmental abnormalities associated with early postnatal ZIKV infection.

Identifiants

DOI: 10.1016/j.jneuroim.2023.578148 PMID: 37451078 PMC: PMC10528946
pubmed: 37451078
pii: S0165-5728(23)00134-0
doi: 10.1016/j.jneuroim.2023.578148
pmc: PMC10528946
mid: NIHMS1919232
pii:
doi:

Substances chimiques

Sofosbuvir WJ6CA3ZU8B
Antiviral Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

578148

Subventions

Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS120182
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest None.

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Auteurs

Alejandra Medina (A)

Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.

Rebecca Rusnak (R)

Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.

Rebecca Richardson (R)

Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.

Matthew G Zimmerman (MG)

Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.

Mehul Suthar (M)

Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.

Nils Schoof (N)

Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.

Zsofia Kovacs-Balint (Z)

Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.

Maud Mavigner (M)

Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.

Mar Sanchez (M)

Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.

Ann Chahroudi (A)

Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA; Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.

Jessica Raper (J)

Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: jraper@emory.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Treatment with sofosbuvir attenuates the...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Flaviviridae › Infections à flavivirus › Infection par le virus Zika › Treatment with sofosbuvir attenuates the...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Flaviviridae › Flavivirus › Virus Zika › Treatment with sofosbuvir attenuates the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Treatment with sofosbuvir attenuates the...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides uridyliques › Uridine monophosphate › Sofosbuvir › Treatment with sofosbuvir attenuates the...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Treatment with sofosbuvir attenuates the...