Gut dysbiosis in Thai intrahepatic cholangiocarcinoma and hepatocellular carcinoma.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 07 2023
14 07 2023
Historique:
received:
19
04
2023
accepted:
06
07
2023
medline:
17
7
2023
pubmed:
15
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Primary liver cancer (PLC), which includes intrahepatic cholangiocarcinoma (iCCA) and hepatocellular carcinoma (HCC), has the highest incidence of all cancer types in Thailand. Known etiological factors, such as viral hepatitis and chronic liver disease do not fully account for the country's unusually high incidence. However, the gut-liver axis, which contributes to carcinogenesis and disease progression, is influenced by the gut microbiome. To investigate this relationship, fecal matter from 44 Thai PLC patients and 76 healthy controls were subjected to whole-genome metagenomic shotgun sequencing and then analyzed by marker gene-based and assembly based methods. Results revealed greater gut microbiome heterogeneity in iCCA compared to HCC and healthy controls. Two Veillonella species were found to be more abundant in iCCA samples and could distinguish iCCA from HCC and healthy controls. Conversely, Ruminococcus gnavus was depleted in iCCA patients and could distinguish HCC from iCCA samples. High Veillonella genus counts in the iCCA group were associated with enriched amino acid biosynthesis and glycolysis pathways, while enriched phospholipid and thiamine metabolism pathways characterized the HCC group with high Blautia genus counts. These findings reveal distinct landscapes of gut dysbiosis among Thai iCCA and HCC patients and warrant further investigation as potential biomarkers.
Identifiants
pubmed: 37452065
doi: 10.1038/s41598-023-38307-2
pii: 10.1038/s41598-023-38307-2
pmc: PMC10349051
doi:
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11406Subventions
Organisme : Intramural NIH HHS
ID : ZIA BC011870
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 BC010877
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 BC010876
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 BC010313
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA BC011870
Pays : United States
Informations de copyright
© 2023. The Author(s).
Références
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Genome Res. 2016 Dec;26(12):1721-1729
pubmed: 27852649
PLoS Negl Trop Dis. 2016 Jul 22;10(7):e0004809
pubmed: 27447938
Bioinformatics. 2016 Oct 1;32(19):3047-8
pubmed: 27312411
Hepatology. 2020 Mar;71(3):893-906
pubmed: 31298745
Nature. 2011 May 12;473(7346):174-80
pubmed: 21508958
Gut. 2016 Oct;65(10):1681-9
pubmed: 27207975
Front Cell Infect Microbiol. 2021 Nov 23;11:751795
pubmed: 34888258
Hepatology. 2011 Jul;54(1):173-84
pubmed: 21488076
Nat Microbiol. 2016 Feb 01;1:15032
pubmed: 27572438
Bioinformatics. 2015 Mar 15;31(6):926-32
pubmed: 25398609
Eur J Gastroenterol Hepatol. 2021 Dec 1;33(1S Suppl 1):e167-e175
pubmed: 33208683
Clin Transl Gastroenterol. 2020 Dec 22;12(1):e00292
pubmed: 33464733
Genome Med. 2020 Nov 23;12(1):102
pubmed: 33225985
Front Immunol. 2021 Sep 23;12:698900
pubmed: 34630385
Elife. 2021 May 04;10:
pubmed: 33944776
Nucleic Acids Res. 2020 Jan 8;48(D1):D445-D453
pubmed: 31586394
Gut. 2019 Jun;68(6):1014-1023
pubmed: 30045880
Bioinformatics. 2019 Feb 1;35(3):421-432
pubmed: 30020410
Sci Rep. 2021 May 19;11(1):10589
pubmed: 34012007
J Microbiol Biotechnol. 2014 Aug;24(8):1026-33
pubmed: 24743571
PLoS Comput Biol. 2021 Nov 16;17(11):e1009442
pubmed: 34784344
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
BMC Genomics. 2017 Mar 14;18(Suppl 2):114
pubmed: 28361695
Hepatol Int. 2022 Feb;16(1):99-111
pubmed: 35064546
BMC Bioinformatics. 2020 Jun 22;21(1):257
pubmed: 32571209
Nucleic Acids Res. 2021 Jul 2;49(W1):W388-W396
pubmed: 34019663
Cancer Cell. 2017 Jul 10;32(1):57-70.e3
pubmed: 28648284
Asian Pac J Cancer Prev. 2014;15(8):3567-70
pubmed: 24870758
J Clin Transl Hepatol. 2015 Sep 28;3(3):182-8
pubmed: 26623264
Nat Rev Gastroenterol Hepatol. 2019 Oct;16(10):589-604
pubmed: 31439937
Biochem Biophys Res Commun. 2016 Jan 22;469(4):967-77
pubmed: 26718401
Hepatobiliary Pancreat Dis Int. 2019 Apr;18(2):149-157
pubmed: 30661942
Genome Res. 2017 May;27(5):849-864
pubmed: 28396521
Genome Biol. 2019 Oct 21;20(1):212
pubmed: 31639026
Nat Microbiol. 2021 Jan;6(1):3-6
pubmed: 33349678
EBioMedicine. 2016 Jun;8:195-202
pubmed: 27428430
Asian Pac J Cancer Prev. 2021 Jan 01;22(1):233-240
pubmed: 33507704
Bioinformatics. 2004 Jan 1;20(1):93-9
pubmed: 14693814
BMC Microbiol. 2013 Sep 14;13:208
pubmed: 24034943
Sci Rep. 2021 Jun 8;11(1):12097
pubmed: 34103600
Nat Med. 2019 Jul;25(7):1104-1109
pubmed: 31235964
Genome Biol. 2011 Jun 24;12(6):R60
pubmed: 21702898
World J Gastrointest Pathophysiol. 2014 Nov 15;5(4):570-8
pubmed: 25401000
Liver Int. 2023 Jan;43(1):221-233
pubmed: 36300678
F1000Res. 2021 Jan 18;10:33
pubmed: 34035898
BMC Pregnancy Childbirth. 2022 Jan 29;22(1):79
pubmed: 35093031
J Hepatol. 2020 Feb;72(2):230-238
pubmed: 31954488
Nucleic Acids Res. 2000 Jan 1;28(1):27-30
pubmed: 10592173
Mil Med Res. 2022 Nov 8;9(1):62
pubmed: 36345047
Front Microbiol. 2021 Jul 15;12:670336
pubmed: 34335499
Hepatology. 2021 Jan;73(1):126-143
pubmed: 32794259