Magnetic susceptibility changes in the brainstem reflect REM sleep without atonia severity in isolated REM sleep behavior disorder.
Journal
NPJ Parkinson's disease
ISSN: 2373-8057
Titre abrégé: NPJ Parkinsons Dis
Pays: United States
ID NLM: 101675390
Informations de publication
Date de publication:
14 Jul 2023
14 Jul 2023
Historique:
received:
19
02
2023
accepted:
05
07
2023
medline:
15
7
2023
pubmed:
15
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
REM sleep without atonia (RWA) is the hallmark of isolated REM sleep behavior disorder (iRBD) and is caused by neurodegeneration of brainstem structures. Previously, quantitative susceptibility mapping (QSM) was shown to detect microstructural tissue changes in neurodegenerative diseases. The goal of the study was to compare brainstem magnetic susceptibility (MS) in iRBD and controls using the voxel-based QSM approach and to examine the association between brainstem MS and severity of RWA in iRBD. Sixty iRBD patients and 41 healthy controls were included in the study. Phasic, tonic, mixed RWA and SINBAR score was quantified. QSM maps were reconstructed with QSMbox software from a multi-gradient-echo sequence acquired at 3T MRI system and normalized using a custom T1 template. Voxel-based analysis with age and gender as covariates was performed using a two-sample t-test model for between-group comparison and using a linear regression model for association with the RWA parameters. Statistical maps were generated using threshold free cluster enhancement with p-value p < 0.05, corrected for family wise error. Compared to controls, the iRBD group had higher MS in bilateral substantia nigra (SN), red nucleus and the ventral tegmental area. MS positively correlated with iRBD duration in the right pedunculotegmental nucleus and white matter of caudal mesencephalic and pontine tegmentum and with phasic RWA in bilateral SN. QSM was able to detect MS abnormalities in several brainstem structures in iRBD. Association of MS levels in the brainstem with the intensity of RWA suggests that increased iron content in SN is related to RWA severity.
Identifiants
pubmed: 37452075
doi: 10.1038/s41531-023-00557-2
pii: 10.1038/s41531-023-00557-2
pmc: PMC10349141
doi:
Types de publication
Journal Article
Langues
eng
Pagination
112Subventions
Organisme : Univerzita Karlova v Praze (Charles University)
ID : Cooperatio Program in Neuroscience
Organisme : Univerzita Karlova v Praze (Charles University)
ID : Cooperatio Program in Neuroscience
Organisme : Univerzita Karlova v Praze (Charles University)
ID : Cooperatio Program in Neuroscience
Organisme : Univerzita Karlova v Praze (Charles University)
ID : Cooperatio Program in Neuroscience
Organisme : Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung)
ID : 31452
Informations de copyright
© 2023. The Author(s).
Références
Neurology. 2010 Sep 14;75(11):950-9
pubmed: 20702790
Sci Rep. 2019 Oct 29;9(1):15463
pubmed: 31664065
Neurobiol Aging. 2003 Mar-Apr;24(2):197-211
pubmed: 12498954
Sleep Med. 2016 Aug;24:147
pubmed: 27697450
AJR Am J Roentgenol. 1986 Jul;147(1):103-10
pubmed: 3487201
Neurology. 2010 Jan 19;74(3):239-44
pubmed: 20083800
Neuroimage. 2022 Oct 15;260:119454
pubmed: 35810938
Sleep Med Rev. 2017 Aug;34:23-33
pubmed: 27542516
Adv Exp Med Biol. 2019;1173:45-66
pubmed: 31456205
Nat Neurosci. 2019 Jan;22(1):106-119
pubmed: 30559475
J Neurosci Res. 2022 Oct;100(10):1815-1833
pubmed: 35790021
BMC Neurol. 2019 Jun 4;19(1):110
pubmed: 31164104
Neurobiol Aging. 2013 May;34(5):1497-503
pubmed: 23177595
Trends Neurosci. 2014 May;37(5):279-88
pubmed: 24673896
Appl Neuropsychol Adult. 2017 Jan-Feb;24(1):23-29
pubmed: 27144665
PLoS One. 2016 Sep 06;11(9):e0162460
pubmed: 27598250
Nat Neurosci. 2014 Mar;17(3):449-54
pubmed: 24487235
BMC Neurosci. 2019 May 22;20(1):23
pubmed: 31117957
J Clin Sleep Med. 2016 Jun 15;12(6):895-903
pubmed: 27070245
Neurology. 2008 Apr 15;70(16 Pt 2):1411-7
pubmed: 18172063
Mov Disord. 2022 Apr;37(4):847-853
pubmed: 34964520
Sleep. 1986 Jun;9(2):293-308
pubmed: 3505730
Lancet Neurol. 2006 Jul;5(7):572-7
pubmed: 16781987
Mov Disord. 2012 May;27(6):677-89
pubmed: 22447623
Neurol Clin. 2005 Nov;23(4):1107-26
pubmed: 16243618
Front Neurol. 2015 May 29;6:123
pubmed: 26074874
J Clin Sleep Med. 2021 Nov 1;17(11):2241-2248
pubmed: 34027887
Neurology. 2010 Aug 10;75(6):494-9
pubmed: 20668263
J Neurol Neurosurg Psychiatry. 2008 Apr;79(4):387-91
pubmed: 17557796
Neurology. 1996 Feb;46(2):388-93
pubmed: 8614500
Int Rev Neurobiol. 2019;144:185-210
pubmed: 30638454
Sleep. 2009 Sep;32(9):1149-53
pubmed: 19750919
Sleep Med. 2019 Apr;56:128-134
pubmed: 30852128
Curr Neurol Neurosci Rep. 2012 Apr;12(2):182-92
pubmed: 22328094
Neuroimage. 2018 Dec;183:7-24
pubmed: 30075277
J Nucl Med. 2018 Sep;59(9):1437-1444
pubmed: 29476004
Nat Commun. 2018 Feb 5;9(1):504
pubmed: 29402935
Neuroimage. 2009 Feb 1;44(3):870-83
pubmed: 18976713
Ann Neurol. 2015 May;77(5):830-9
pubmed: 25767079
Mov Disord. 2017 May;32(5):636-644
pubmed: 28394031
PLoS One. 2014 Feb 26;9(2):e89741
pubmed: 24587002
J Neural Transm (Vienna). 2020 Feb;127(2):181-187
pubmed: 32025811
Neurology. 1992 Jul;42(7):1371-4
pubmed: 1620348
Mov Disord. 2007 Jan;22(1):41-7
pubmed: 17115387
Front Neuroanat. 2021 Aug 13;15:627656
pubmed: 34483849
Sleep. 2019 Feb 1;42(2):
pubmed: 30445515
Brain. 2007 Nov;130(Pt 11):2770-88
pubmed: 17412731
Sleep Med Rev. 2011 Jun;15(3):153-63
pubmed: 21115377
Neuroimage. 2004 Nov;23(3):860-8
pubmed: 15528086
Sleep Med. 2021 Jul;83:132-144
pubmed: 33993030
Neurology. 2019 Sep 17;93(12):e1171-e1179
pubmed: 31420463
Nat Commun. 2022 Dec 7;13(1):7552
pubmed: 36477665
Surg Neurol Int. 2021 Jul 27;12:377
pubmed: 34513144
Neurology. 2018 May 15;90(20):e1759-e1770
pubmed: 29669906
J Neuroimaging. 2021 Sep;31(5):1020-1027
pubmed: 34033185
Neuroimage. 2014 Jun;93 Pt 1:95-106
pubmed: 24607447
Cell Tissue Res. 2018 Jul;373(1):245-266
pubmed: 29846796
Biochim Biophys Acta. 2009 Jul;1790(7):606-14
pubmed: 18778755
Sleep. 2019 Sep 6;42(9):
pubmed: 31194249
Neuropsychologia. 1971 Mar;9(1):97-113
pubmed: 5146491
Mov Disord. 2007 Dec;22(16):2386-93
pubmed: 17894337
Magn Reson Imaging. 2015 Jun;33(5):559-65
pubmed: 25721997
Sleep Med. 2013 Aug;14(8):744-8
pubmed: 23347909
Neurology. 2009 Apr 14;72(15):1296-300
pubmed: 19109537
Sleep. 2012 Jun 01;35(6):835-47
pubmed: 22654203
Magn Reson Med. 2018 Jun;79(6):2996-3006
pubmed: 29034511
Parkinsonism Relat Disord. 2014 Jul;20(7):776-8
pubmed: 24731528
Mov Disord. 2020 Mar;35(3):478-485
pubmed: 31846123
Lancet Neurol. 2021 Aug;20(8):671-684
pubmed: 34302789
Neuroimage. 2012 Sep;62(3):1593-9
pubmed: 22634862
Sleep Med. 2013 Aug;14(8):699-702
pubmed: 23768839
Front Neuroanat. 2011 Apr 05;5:22
pubmed: 21503154
Hum Brain Mapp. 2015 Nov;36(11):4407-20
pubmed: 26249218
Ann Clin Transl Neurol. 2020 Jan;7(1):26-35
pubmed: 31820587
Nat Rev Neurol. 2018 Jan;14(1):40-55
pubmed: 29170501
Brain. 2019 Mar 1;142(3):744-759
pubmed: 30789229
Sleep. 2013 Aug 01;36(8):1147-52
pubmed: 23904674