Heart transplantation: advances in expanding the donor pool and xenotransplantation.


Journal

Nature reviews. Cardiology
ISSN: 1759-5010
Titre abrégé: Nat Rev Cardiol
Pays: England
ID NLM: 101500075

Informations de publication

Date de publication:
Jan 2024
Historique:
accepted: 13 06 2023
pubmed: 15 7 2023
medline: 15 7 2023
entrez: 14 7 2023
Statut: ppublish

Résumé

Approximately 65 million adults globally have heart failure, and the prevalence is expected to increase substantially with ageing populations. Despite advances in pharmacological and device therapy of heart failure, long-term morbidity and mortality remain high. Many patients progress to advanced heart failure and develop persistently severe symptoms. Heart transplantation remains the gold-standard therapy to improve the quality of life, functional status and survival of these patients. However, there is a large imbalance between the supply of organs and the demand for heart transplants. Therefore, expanding the donor pool is essential to reduce mortality while on the waiting list and improve clinical outcomes in this patient population. A shift has occurred to consider the use of organs from donors with hepatitis C virus, HIV or SARS-CoV-2 infection. Other advances in this field have also expanded the donor pool, including opt-out donation policies, organ donation after circulatory death and xenotransplantation. We provide a comprehensive overview of these various novel strategies, provide objective data on their safety and efficacy, and discuss some of the unresolved issues and controversies of each approach.

Identifiants

pubmed: 37452122
doi: 10.1038/s41569-023-00902-1
pii: 10.1038/s41569-023-00902-1
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

25-36

Informations de copyright

© 2023. Springer Nature Limited.

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Auteurs

Stephanie Jou (S)

The Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai Hospital, New York, NY, USA. stephanie.jou@mountsinai.org.

Sean R Mendez (SR)

The Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai Hospital, New York, NY, USA.

Jason Feinman (J)

The Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai Hospital, New York, NY, USA.

Lindsey R Mitrani (LR)

The Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai Hospital, New York, NY, USA.

Valentin Fuster (V)

The Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai Hospital, New York, NY, USA.

Massimo Mangiola (M)

Transplant Institute, New York University Langone Health, New York, NY, USA.

Nader Moazami (N)

Department of Cardiothoracic Surgery, New York University Langone Health, New York, NY, USA.

Claudia Gidea (C)

The Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai Hospital, New York, NY, USA.

Classifications MeSH