High-dose folic acid and cancer risk; unjustified concerns by von Wrede and colleagues regarding our paper.
B vitamins
anticonvulsant drugs
antiepileptic drug
childhood cancer
epilepsy
folate
pregnancy
Journal
Epilepsia
ISSN: 1528-1167
Titre abrégé: Epilepsia
Pays: United States
ID NLM: 2983306R
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
06
07
2023
accepted:
12
07
2023
medline:
20
9
2023
pubmed:
15
7
2023
entrez:
15
7
2023
Statut:
ppublish
Résumé
Women using antiseizure medication in pregnancy are often advised to use high doses of folic acid supplements (1mg to 5 mg) to reduce the risk of teratogenicity. Recently, we published a report showing an association between maternal prescription fill of high dose folic acid in relation to pregnancy and childhood cancer in the offspring. The report has sparked a debate about which dose of folic acid that should be recommended in pregnancy in women in need of antiseizure medication. In this Commentary, we explain our findings and the method used in our report, and answer recent questions that have emerged.
Substances chimiques
Folic Acid
935E97BOY8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
2244-2248Commentaires et corrections
Type : CommentOn
Informations de copyright
© 2023 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.
Références
Vegrim HM, Dreier JW, Alvestad S, Gilhus NE, Gissler M, Igland J, et al. Cancer risk in children of mothers with epilepsy and high-dose folic acid use during pregnancy. JAMA Neurol. 2022;79:1130-1138.
von Wrede R, Witt JA, Auvin S, Devlin A, Lagae L, Marson A, et al. Unjustified allegation on cancer risks in children of mothers with epilepsy taking high-dose folic acid during pregnancy-No proof of a causal relationship. Epilepsia. 2023.
Vegrim HM, Tomson T, Bjørk MH. Benefits and risks of periconceptional folic acid supplementation-reply. JAMA Neurol. 2023;80:421-422.
Marcotte EL, Spector LG, Mendes-de-Almeida DP, Nelson HH. The prenatal origin of childhood leukemia: potential applications for epidemiology and newborn screening. Front Pediatr. 2021;9:639479.
Bjork MH, Zoega H, Leinonen MK, Cohen JM, Dreier JW, Furu K, et al. Association of prenatal exposure to antiseizure medication with risk of autism and intellectual disability. JAMA Neurol. 2022;79:672-681.
Dreier JW, Bjork MH, Alvestad S, Gissler M, Igland J, Leinonen MK, et al. Prenatal exposure to antiseizure medication and incidence of childhood- and adolescence-onset psychiatric disorders. JAMA Neurol. 2023;80:568-577.
Syvertsen M, Nakken KO, Edland A, Hansen G, Hellum MK, Koht J. Prevalence and etiology of epilepsy in a Norwegian county-a population based study. Epilepsia. 2015;56:699-706.
Christensen J, Vestergaard M, Pedersen MG, Pedersen CB, Olsen J, Sidenius P. Incidence and prevalence of epilepsy in Denmark. Epilepsy Res. 2007;76:60-65.
Annegers JF, Hauser WA, Elveback LR. Remission of seizures and relapse in patients with epilepsy. Epilepsia. 1979;20:729-737.
Cohen JM, Cesta CE, Furu K, Einarsdóttir K, Gissler M, Havard A, et al. Prevalence trends and individual patterns of antiepileptic drug use in pregnancy 2006-2016: A study in the five Nordic countries, United States, and Australia. Pharmacoepidemiol Drug Saf. 2020;29(8):913-922.
Laugesen K, Ludvigsson JF, Schmidt M, Gissler M, Valdimarsdottir UA, Lunde A, et al. Nordic health registry-based research: a review of health care systems and key registries. Clin Epidemiol. 2021;13:533-554.
Pottegård A, Schmidt SAJ, Wallach-Kildemoes H, Sørensen HT, Hallas J, Schmidt M. Data resource profile: The Danish National Prescription Registry. Int J Epidemiol. 2017;46:798-798f.
Olesen C, Søndergaard C, Thrane N, Lauge Nielsen G, de Jong-van den Berg L, Olsen J, et al. Do pregnant women report use of dispensed medications? Epidemiology. 2001;12:497-501.
Christensen J, Gronborg TK, Sorensen MJ, Schendel D, Parner ET, Pedersen LH, et al. Prenatal valproate exposure and risk of autism Spectrum disorders and childhood autism. JAMA. 2013;309:1696-1703.
Bech BH, Kjaersgaard MI, Pedersen HS, Howards PP, Sørensen MJ, Olsen J, et al. Use of antiepileptic drugs during pregnancy and risk of spontaneous abortion and stillbirth: population based cohort study. BMJ. 2014;349:g5159.
Shane B. Folate and vitamin B12 metabolism: overview and interaction with riboflavin, vitamin B6, and polymorphisms. Food Nutr Bull. 2008;29:S5-S16. discussion S17-19.