Structure-function relationship of new peptides activating human Na

Humans Peptides / pharmacology Voltage-Gated Sodium Channels Structure-Activity Relationship
Automated patch clamp Biophysics Cellular assay Dravet disease Drug discovery High-throughput screening JzTx-34 Lead optimization Peptide synthesis Pharmacology Structural functional relationships hNa(v)1.1 channel

Journal

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295

Informations de publication

Date de publication:
Sep 2023
Historique:
received: 23 03 2023
revised: 11 07 2023
accepted: 12 07 2023
medline: 17 8 2023
pubmed: 16 7 2023
entrez: 15 7 2023
Statut: ppublish

Résumé

Na

Identifiants

DOI: 10.1016/j.biopha.2023.115173 PMID: 37453200
pubmed: 37453200
pii: S0753-3322(23)00964-2
doi: 10.1016/j.biopha.2023.115173
pii:
doi:

Substances chimiques

Peptides 0
Voltage-Gated Sodium Channels 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

115173

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: CC and RB are employee and CEO of Smartox Biotechnology, respectively. MDW is a founder and consultant of Smartox Biotechnology. KK, SL and JPJ are employees of Xenon Pharmaceuticals. CC is a past employee of Xenon Pharmaceuticals.

Auteurs

Ludivine Lopez (L)

Nantes Université, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France; Smartox Biotechnology, Saint-Egrève, France.

Stephan De Waard (S)

Nantes Université, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France; LabEx "Ion Channels, Science and Therapeutics", Valbonne, France.

Hervé Meudal (H)

Center for Molecular Biophysics, CNRS, rue Charles Sadron, CS 80054, Orléans 45071, France.

Cécile Caumes (C)

Smartox Biotechnology, Saint-Egrève, France.

Kuldip Khakh (K)

Xenon Pharmaceuticals, Burnaby, British Columbia, Canada.

Steve Peigneur (S)

University of Leuven, 3000 Leuven, Belgium.

Barbara Oliveira-Mendes (B)

Nantes Université, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France.

Sophia Lin (S)

Xenon Pharmaceuticals, Burnaby, British Columbia, Canada.

Jolien De Waele (J)

Department of Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium.

Jérôme Montnach (J)

Nantes Université, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France.

Sandrine Cestèle (S)

Université Cote d'Azur, CNRS UMR 7275, Institute of Molecular and Cellular Pharmacology, Valbonne-Sophia Antipolis, France.

Agnès Tessier (A)

Nantes Université, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France.

J P Johnson (JP)

Xenon Pharmaceuticals, Burnaby, British Columbia, Canada.

Massimo Mantegazza (M)

Université Cote d'Azur, CNRS UMR 7275, Institute of Molecular and Cellular Pharmacology, Valbonne-Sophia Antipolis, France.

Jan Tytgat (J)

University of Leuven, 3000 Leuven, Belgium.

Charles Cohen (C)

Xenon Pharmaceuticals, Burnaby, British Columbia, Canada.

Rémy Béroud (R)

Smartox Biotechnology, Saint-Egrève, France.

Frank Bosmans (F)

Department of Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium.

Céline Landon (C)

Center for Molecular Biophysics, CNRS, rue Charles Sadron, CS 80054, Orléans 45071, France.

Michel De Waard (M)

Nantes Université, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France; Smartox Biotechnology, Saint-Egrève, France; LabEx "Ion Channels, Science and Therapeutics", Valbonne, France. Electronic address: michel.dewaard@univ-nantes.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structure-function relationship of new...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Structure-function relationship of new...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Structure-function relationship of new...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Structure-function relationship of new...