Choroidal thickness and choroidal vascularity index changes in children with type 1 diabetes mellitus without retinopathy.
Binarization
Choroidal vascularity index
Enhanced-depth imaging optical coherence tomography
Type 1 diabetes mellitus
Journal
Photodiagnosis and photodynamic therapy
ISSN: 1873-1597
Titre abrégé: Photodiagnosis Photodyn Ther
Pays: Netherlands
ID NLM: 101226123
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
09
05
2023
revised:
19
06
2023
accepted:
11
07
2023
medline:
8
9
2023
pubmed:
16
7
2023
entrez:
15
7
2023
Statut:
ppublish
Résumé
Diabetic retinopathy is one of the most important causes of low vision in the working age group. Retinopathy findings start earlier and have a worse prognosis in type 1 DM. The aim of the this study was to compare the choroidal thickness (CT) and choroidal vascular index (CVI) values of type 1 diabetes mellitus (DM) patients without retinopathy findings in pediatric patients and healthy children. The study included 89 children, including 43 type 1 DM patients and 46 healthy controls. The age, gender, duration of DM, hemoglobin A1c (HbA1c), refractive error, intraocular pressure (IOP) and axial length (AL) of the participants were noted. CT measurements were performed subfoveally, 1000 µm from the fovea in the nasal and temporal quadrants. The total choroidal area (TCA), luminal area (LA) and stromal area (SA) were calculated using the binarization method using the image J program. The CVI was determined by dividing the luminal area by the total choroidal area. There were no significant differences between the participants in terms of age, gender, spherical equivalent, IOP, and AL. There was no significant difference between the groups in terms of CT. TCA, LA and SA values were significantly higher in the Type 1 DM group (p=0.034, p=0.036, p=0.037, respectively). There was no significant difference between the groups in terms of the CVI. The TCA, LA, and SA values were significantly higher in the type 1 DM group. LA/SA and CVI values were lower in the type 1 DM group, although not significantly. There was a negative correlation between the duration of DM and LA/SA as well as CVI. This suggests that vascular reduction starts in the early stages.
Sections du résumé
BACKGROUND
BACKGROUND
Diabetic retinopathy is one of the most important causes of low vision in the working age group. Retinopathy findings start earlier and have a worse prognosis in type 1 DM. The aim of the this study was to compare the choroidal thickness (CT) and choroidal vascular index (CVI) values of type 1 diabetes mellitus (DM) patients without retinopathy findings in pediatric patients and healthy children.
METHODS
METHODS
The study included 89 children, including 43 type 1 DM patients and 46 healthy controls. The age, gender, duration of DM, hemoglobin A1c (HbA1c), refractive error, intraocular pressure (IOP) and axial length (AL) of the participants were noted. CT measurements were performed subfoveally, 1000 µm from the fovea in the nasal and temporal quadrants. The total choroidal area (TCA), luminal area (LA) and stromal area (SA) were calculated using the binarization method using the image J program. The CVI was determined by dividing the luminal area by the total choroidal area.
RESULTS
RESULTS
There were no significant differences between the participants in terms of age, gender, spherical equivalent, IOP, and AL. There was no significant difference between the groups in terms of CT. TCA, LA and SA values were significantly higher in the Type 1 DM group (p=0.034, p=0.036, p=0.037, respectively). There was no significant difference between the groups in terms of the CVI.
CONCLUSIONS
CONCLUSIONS
The TCA, LA, and SA values were significantly higher in the type 1 DM group. LA/SA and CVI values were lower in the type 1 DM group, although not significantly. There was a negative correlation between the duration of DM and LA/SA as well as CVI. This suggests that vascular reduction starts in the early stages.
Identifiants
pubmed: 37453471
pii: S1572-1000(23)00433-7
doi: 10.1016/j.pdpdt.2023.103706
pii:
doi:
Substances chimiques
Photosensitizing Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103706Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no conflict of interest.