Decoding information about cognitive health from the brainwaves of sleep.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 07 2023
15 07 2023
Historique:
received:
30
08
2022
accepted:
16
06
2023
medline:
17
7
2023
pubmed:
16
7
2023
entrez:
15
7
2023
Statut:
epublish
Résumé
Sleep electroencephalogram (EEG) signals likely encode brain health information that may identify individuals at high risk for age-related brain diseases. Here, we evaluate the correlation of a previously proposed brain age biomarker, the "brain age index" (BAI), with cognitive test scores and use machine learning to develop and validate a series of new sleep EEG-based indices, termed "sleep cognitive indices" (SCIs), that are directly optimized to correlate with specific cognitive scores. Three overarching cognitive processes were examined: total, fluid (a measure of cognitive processes involved in reasoning-based problem solving and susceptible to aging and neuropathology), and crystallized cognition (a measure of cognitive processes involved in applying acquired knowledge toward problem-solving). We show that SCI decoded information about total cognition (Pearson's r = 0.37) and fluid cognition (Pearson's r = 0.56), while BAI correlated only with crystallized cognition (Pearson's r = - 0.25). Overall, these sleep EEG-derived biomarkers may provide accessible and clinically meaningful indicators of neurocognitive health.
Identifiants
pubmed: 37454163
doi: 10.1038/s41598-023-37128-7
pii: 10.1038/s41598-023-37128-7
pmc: PMC10349883
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11448Subventions
Organisme : NINDS NIH HHS
ID : R01 NS102190
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS102574
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107291
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG064312
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG029289
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG073410
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG064312
Pays : United States
Informations de copyright
© 2023. The Author(s).
Références
Ann Med. 2015;47(6):482-91
pubmed: 26224201
J Clin Sleep Med. 2014 Jun 15;10(6):613-21
pubmed: 24932140
Neurobiol Learn Mem. 2019 Dec;166:107100
pubmed: 31622665
Neurology. 2017 Dec 12;89(24):2447-2454
pubmed: 29117954
Sleep. 2007 Dec;30(12):1643-57
pubmed: 18246974
J Alzheimers Dis. 2021;79(2):807-817
pubmed: 33361590
J Gerontol A Biol Sci Med Sci. 2002 Mar;57(3):M173-7
pubmed: 11867654
PLoS One. 2015 May 13;10(5):e0125752
pubmed: 25970511
Clin Neurophysiol. 2021 Jan;132(1):1-12
pubmed: 33248430
Am J Epidemiol. 1979 Sep;110(3):281-90
pubmed: 474565
Physiol Rev. 2020 Apr 1;100(2):805-868
pubmed: 31804897
Monogr Soc Res Child Dev. 2013 Aug;78(4):119-32
pubmed: 23952206
BMC Health Serv Res. 2019 Nov 29;19(1):919
pubmed: 31783848
PLoS One. 2014 Dec 01;9(12):e113734
pubmed: 25437848
Alzheimer Dis Assoc Disord. 2009 Oct-Dec;23(4):306-14
pubmed: 19568149
CMAJ Open. 2017 Aug 14;5(3):E623-E631
pubmed: 28811281
Front Hum Neurosci. 2013 Jun 20;7:292
pubmed: 23801955
Clin Neurophysiol. 2002 Oct;113(10):1615-22
pubmed: 12350438
Neurobiol Aging. 2020 Apr;88:150-155
pubmed: 31932049
Alzheimer Dis Assoc Disord. 2016 Jan-Mar;30(1):35-40
pubmed: 26523710
Sleep. 1998 Nov 1;21(7):759-67
pubmed: 11300121
J Am Med Inform Assoc. 2018 Oct 1;25(10):1351-1358
pubmed: 29860441
Front Neurol. 2013 Oct 11;4:159
pubmed: 24130550
Psychol Aging. 2013 Sep;28(3):595-613
pubmed: 24040999
Sleep. 1997 Dec;20(12):1077-85
pubmed: 9493915
Nat Neurosci. 2015 Nov;18(11):1679-1686
pubmed: 26389842
Nat Hum Behav. 2021 Jan;5(1):123-145
pubmed: 33199858
JAMA Neurol. 2021 Oct 1;78(10):1187-1196
pubmed: 34459862
Neuron. 2017 Apr 5;94(1):19-36
pubmed: 28384471
Curr Top Behav Neurosci. 2015;25:307-30
pubmed: 24652608
Proc Natl Acad Sci U S A. 2008 May 13;105(19):6829-33
pubmed: 18443283
Neuron. 2018 Jan 3;97(1):221-230.e4
pubmed: 29249289
Neurosci Biobehav Rev. 2011 Apr;35(5):1154-65
pubmed: 21167865
J Am Geriatr Soc. 2014 Jun;62(6):1073-81
pubmed: 24786726
Psychophysiology. 2001 Mar;38(2):232-42
pubmed: 11347869
Neuroscience. 2006;138(1):351-6
pubmed: 16388912
Sleep. 2016 May 01;39(5):1151-64
pubmed: 27070134
Psychol Aging. 2020 Mar;35(2):220-249
pubmed: 32011155
Neurobiol Aging. 2016 Oct;46:68-75
pubmed: 27460151
Sleep. 2021 Aug 13;44(8):
pubmed: 33783511
Semin Neurol. 2017 Aug;37(4):395-406
pubmed: 28837986
Neurobiol Aging. 2019 Feb;74:112-120
pubmed: 30448611
Sleep. 2014 Apr 01;37(4):655-63
pubmed: 24899757
JAMA Netw Open. 2020 Sep 1;3(9):e2017357
pubmed: 32986106
Hum Brain Mapp. 2020 Mar;41(4):906-916
pubmed: 32026600
Sleep. 2004 Nov 1;27(7):1255-73
pubmed: 15586779
J Int Neuropsychol Soc. 2014 Jul;20(6):567-78
pubmed: 24959840
Neuropsychology. 2017 Nov;31(8):846-861
pubmed: 29376667
Sleep. 2011 May 01;34(5):575-80
pubmed: 21532950
Nat Commun. 2017 Jun 26;8:15930
pubmed: 28649997
Psychol Rep. 1987 Jun;60(3 Pt 2):1023-40
pubmed: 3628637
Sleep. 2017 Oct 1;40(10):
pubmed: 29029305
N Engl J Med. 2016 Feb 11;374(6):523-32
pubmed: 26863354
Nature. 2004 Jul 1;430(6995):78-81
pubmed: 15184907
Mol Psychiatry. 2018 May;23(5):1385-1392
pubmed: 28439103