Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions: reevaluation of the defining characteristics in a registry-based cohort.


Journal

Leukemia
ISSN: 1476-5551
Titre abrégé: Leukemia
Pays: England
ID NLM: 8704895

Informations de publication

Date de publication:
09 2023
Historique:
received: 12 10 2022
accepted: 27 06 2023
revised: 18 05 2023
medline: 28 8 2023
pubmed: 16 7 2023
entrez: 15 7 2023
Statut: ppublish

Résumé

In a registry-based analysis of 135 patients with "myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions" (MLN-TK; FIP1L1::PDGFRA, n = 78; PDGFRB, diverse fusions, n = 26; FGFR1, diverse, n = 9; JAK2, diverse, n = 11; ETV6::ABL1, n = 11), we sought to evaluate the disease-defining characteristics. In 81/135 (60%) evaluable patients, hypereosinophilia (>1.5 × 10

Identifiants

pubmed: 37454239
doi: 10.1038/s41375-023-01958-1
pii: 10.1038/s41375-023-01958-1
pmc: PMC10457188
doi:

Substances chimiques

Receptor, Platelet-Derived Growth Factor beta EC 2.7.10.1
Receptor, Platelet-Derived Growth Factor alpha EC 2.7.10.1
Oncogene Proteins, Fusion 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1860-1867

Informations de copyright

© 2023. The Author(s).

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Auteurs

Georgia Metzgeroth (G)

Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.

Laurenz Steiner (L)

Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.

Nicole Naumann (N)

Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.

Johannes Lübke (J)

Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.

Sebastian Kreil (S)

Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.

Alice Fabarius (A)

Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.

Claudia Haferlach (C)

Munich Leukemia Laboratory, Munich, Germany.

Torsten Haferlach (T)

Munich Leukemia Laboratory, Munich, Germany.

Wolf-Karsten Hofmann (WK)

Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.

Nicholas C P Cross (NCP)

Wessex Regional Genetics Laboratory, Salisbury, UK.
Faculty of Medicine, University of Southampton, Southampton, UK.

Juliana Schwaab (J)

Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.

Andreas Reiter (A)

Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany. andreas.reiter@medma.uni-heidelberg.de.

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Classifications MeSH