Metabolic dysfunction-associated gallstone disease: expecting more from critical care manifestations.
Bile
Biliary colic
Biliary secretion
CT scan
Cholecystectomy
Cholecystitis
Choledocholithiasis
Cholesterol crystallization
ERCP
MRCP
Journal
Internal and emergency medicine
ISSN: 1970-9366
Titre abrégé: Intern Emerg Med
Pays: Italy
ID NLM: 101263418
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
19
05
2023
accepted:
22
06
2023
medline:
4
10
2023
pubmed:
17
7
2023
entrez:
16
7
2023
Statut:
ppublish
Résumé
About 20% of adults worldwide have gallstones which are solid conglomerates in the biliary tree made of cholesterol monohydrate crystals, mucin, calcium bilirubinate, and protein aggregates. About 20% of gallstone patients will definitively develop gallstone disease, a condition which consists of gallstone-related symptoms and/or complications requiring medical therapy, endoscopic procedures, and/or cholecystectomy. Gallstones represent one of the most prevalent digestive disorders in Western countries and patients with gallstone disease are one of the largest categories admitted to European hospitals. About 80% of gallstones in Western countries are made of cholesterol due to disturbed cholesterol homeostasis which involves the liver, the gallbladder and the intestine on a genetic background. The incidence of cholesterol gallstones is dramatically increasing in parallel with the global epidemic of insulin resistance, type 2 diabetes, expansion of visceral adiposity, obesity, and metabolic syndrome. In this context, gallstones can be largely considered a metabolic dysfunction-associated gallstone disease, a condition prone to specific and systemic preventive measures. In this review we discuss the key pathogenic and clinical aspects of gallstones, as the main clinical consequences of metabolic dysfunction-associated disease.
Identifiants
pubmed: 37455265
doi: 10.1007/s11739-023-03355-z
pii: 10.1007/s11739-023-03355-z
pmc: PMC10543156
doi:
Substances chimiques
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1897-1918Subventions
Organisme : HORIZON EUROPE Marie Sklodowska-Curie Actions
ID : 722619
Organisme : HORIZON EUROPE Marie Sklodowska-Curie Actions
ID : 734719
Organisme : Regione Puglia
ID : H99C20000340002 Fever Apulia
Organisme : Universita degli Studi di Bari Aldo Moro
ID : EUROSEEDS Uniba - S56
Informations de copyright
© 2023. The Author(s).
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