Severe Hypoglycemia and the Use of Glucagon Rescue Agents: An Observational Survey in Adults With Type 1 Diabetes.
Journal
Clinical diabetes : a publication of the American Diabetes Association
ISSN: 0891-8929
Titre abrégé: Clin Diabetes
Pays: United States
ID NLM: 8406985
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
17
7
2023
pubmed:
17
7
2023
entrez:
17
7
2023
Statut:
ppublish
Résumé
Severe hypoglycemia (SH) is the most frequent and potentially serious complication affecting individuals with type 1 diabetes and can have major clinical and psychosocial consequences. Glucagon is the only approved treatment for SH that can be administered by non-health care professionals (HCPs); however, reports on the experiences and emotions of people with type 1 diabetes associated with SH and glucagon rescue use are limited. This survey study demonstrated that an increasing number of individuals with type 1 diabetes have current and filled prescriptions for glucagon and have been educated about glucagon rescue use by an HCP. Despite this positive trend, challenges with SH remain, including a high level of health care resource utilization, considerable out-of-pocket expenses for glucagon kits, a high prevalence of hypoglycemia unawareness, and a negative emotional impact on individuals with diabetes. Nocturnal and exercise-related hypoglycemia were concerns for most survey participants.
Identifiants
pubmed: 37456102
doi: 10.2337/cd22-0099
pii: CD220099
pmc: PMC10338275
doi:
Types de publication
Journal Article
Langues
eng
Pagination
399-410Informations de copyright
© 2023 by the American Diabetes Association.
Déclaration de conflit d'intérêts
S.A.W. has received consulting fees from Zealand Pharma independent of the submitted work. M.W. is a former employee of Zealand Pharma. No other potential conflicts of interest relevant to this article were reported.
Références
Diabetes Technol Ther. 2020 Feb;22(2):121-130
pubmed: 31886730
Endocr Pract. 2018 Oct 2;24(10):861-866
pubmed: 30035620
Biomolecules. 2021 Aug 27;11(9):
pubmed: 34572493
Endocr Pract. 2016 Feb;22(2):123-35
pubmed: 26484405
Diabetes Educ. 2014 May;40(3):269-279
pubmed: 24695260
Pediatr Diabetes. 2018 Oct;19 Suppl 27:178-192
pubmed: 29869358
Diabet Med. 2014 Oct;31(10):1210-7
pubmed: 24824356
J Med Econ. 2015 Jun;18(6):420-32
pubmed: 25629654
Pediatr Diabetes. 2007 Dec;8(6):362-8
pubmed: 18036061
J Manag Care Spec Pharm. 2022 Apr;28(4):461-472
pubmed: 35332789
N Engl J Med. 2013 Jul 25;369(4):362-72
pubmed: 23883381
Diabetes Care. 2022 Jan 1;45(Suppl 1):S83-S96
pubmed: 34964868
J Clin Res Pediatr Endocrinol. 2021 Jan 25;13(3):285-292
pubmed: 33491925
Patient Educ Couns. 2007 Sep;68(1):10-5
pubmed: 17582726
Diabetes Technol Ther. 2019 Sep;21(9):522-530
pubmed: 31219349
J Clin Psychol Med Settings. 2011 Dec;18(4):345-52
pubmed: 21643962
Diabetes Care. 2017 Dec;40(12):1622-1630
pubmed: 29162582
Diabetes Care. 2017 Aug;40(8):1010-1016
pubmed: 28550194
Clin Diabetes. 2019 Apr;37(2):162-166
pubmed: 31057222
Exp Clin Endocrinol Diabetes. 2022 Mar;130(3):145-155
pubmed: 33368091
Exp Physiol. 2020 Apr;105(4):590-599
pubmed: 31785115
Endocr Pract. 2020 Apr;26(4):407-415
pubmed: 32293921
World J Diabetes. 2015 Oct 10;6(13):1246-58
pubmed: 26468341
Endocrinol Diabetes Nutr (Engl Ed). 2021 Oct;68(8):557-566
pubmed: 34872639
Diabetes Care. 2016 Sep;39(9):1571-8
pubmed: 27385329
Expert Rev Pharmacoecon Outcomes Res. 2013 Feb;13(1):123-30
pubmed: 23402452
Diabetes Care. 2015 Feb;38(2):316-22
pubmed: 25492401
J Diabetes Complications. 2021 May;35(5):107882
pubmed: 33593689
Ann Endocrinol (Paris). 2022 Feb;83(1):16-26
pubmed: 34871601
Can J Diabetes. 2021 Apr;45(3):236-242
pubmed: 33087294
Curr Diab Rep. 2022 Apr;22(4):189-197
pubmed: 35171447
Diabetes Care. 1994 Jul;17(7):697-703
pubmed: 7924780
Pharmacoecon Open. 2020 Sep;4(3):519-528
pubmed: 31997126
Medicine (Baltimore). 2016 Nov;95(47):e5365
pubmed: 27893672
Endocrinol Metab Clin North Am. 2013 Mar;42(1):15-38
pubmed: 23391237
Diabetes Ther. 2022 Mar;13(3):517-533
pubmed: 35199292
Diabetes Metab Syndr Obes. 2011;4:337-46
pubmed: 21969805
Diabetes Care. 2018 May;41(5):917-928
pubmed: 29567642