Comorbidity in bullous pemphigoid: up-date and clinical implications.

autoimmune skin blistering disease bullous pemphigoid comorbidity inflammatory disease malignancy metabolic disease neurologic disease

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2023
Historique:
received: 30 03 2023
accepted: 19 05 2023
medline: 18 7 2023
pubmed: 17 7 2023
entrez: 17 7 2023
Statut: epublish

Résumé

Bullous pemphigoid is the most common autoimmune blistering disease in industrialized countries and particularly affects the elderly. In this patient population, comorbid diseases are frequent and may complicate management and treatment of bullous pemphigoid. A better understanding why distinct diseases are more frequent in bullous pemphigoid patients may lead to new pathophysiological insights and - as a consequence - result in better patient care. The association of bullous pemphigoid with neurological and psychiatric diseases is well known and confirmed by several case-control studies. Association with further diseases such as malignancy and metabolic diseases are still discussed controversially. In recent years new relationships between bullous pemphigoid and autoimmune as well as inflammatory skin diseases have been reported. This review provides a systematic overview on studies addressing comorbidity in bullous pemphigoid patients. Increasing the awareness of both, common and rare comorbid diseases, may enable clinicians to optimize patient support and individualized treatment of bullous pemphigoid.

Identifiants

pubmed: 37457698
doi: 10.3389/fimmu.2023.1196999
pmc: PMC10346857
doi:

Types de publication

Systematic Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1196999

Informations de copyright

Copyright © 2023 Huttelmaier, Benoit and Goebeler.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Johanna Huttelmaier (J)

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

Sandrine Benoit (S)

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

Matthias Goebeler (M)

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

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