Effects of Leptin and Body Weight on Inflammation and Knee Osteoarthritis Phenotypes in Female Rats.
ADIPOKINES
KNEE
METABOLIC SYNDROME
METABOLISM
OBESITY
OSTEOARTHRITIS
Journal
JBMR plus
ISSN: 2473-4039
Titre abrégé: JBMR Plus
Pays: England
ID NLM: 101707013
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
18
01
2023
revised:
22
03
2023
accepted:
13
04
2023
medline:
17
7
2023
pubmed:
17
7
2023
entrez:
17
7
2023
Statut:
epublish
Résumé
Leptin is a proinflammatory adipokine that contributes to obesity-associated osteoarthritis (OA), especially in women. However, the extent to which leptin causes knee OA separate from the effect of increased body weight is not clear. We hypothesized that leptin is necessary to induce knee OA in obese female rats but not sufficient to induce knee OA in lean rats lacking systemic metabolic inflammation. The effect of obesity without leptin signaling was modeled by comparing female lean Zucker rats to pair fed obese Zucker rats, which possess mutant
Identifiants
pubmed: 37457883
doi: 10.1002/jbm4.10754
pii: JBM410754
pmc: PMC10339097
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10754Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103447
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028716
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM114731
Pays : United States
Informations de copyright
© 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
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