Prebiotics: Ignored player in the fight against cancer.
cancer
microbiome
prebiotics
tumour
Journal
Cancer reports (Hoboken, N.J.)
ISSN: 2573-8348
Titre abrégé: Cancer Rep (Hoboken)
Pays: United States
ID NLM: 101747728
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
revised:
24
05
2023
received:
22
03
2023
accepted:
30
06
2023
medline:
15
11
2023
pubmed:
17
7
2023
entrez:
17
7
2023
Statut:
ppublish
Résumé
Prebiotics is a relatively neglected area in cancer research, despite evidence suggesting that it plays a key role in suppressing tumour growth and improving immune function. Including prebiotics in the diet has been shown to strengthen the immune system and can better slow down or prevent the growth of tumours. It has also been strongly indicated in various scientific studies that prebiotics can contribute to the sustenance of a healthy microbiome, which in turn plays an important role in increasing the effectiveness and reducing the side effects of cancer treatments. In the present review article we highlight the mechanisms by which prebiotics like inulin, fructooligosaccharide (FOS), β-glucan, pectin, and xylooligosaccharide (XOS) function. Furthermore, the beneficial effect of incorporating prebiotics during cancer therapy to improvise gut health and prevent/reverse the damage caused to patients due to chemotherapy has also been elaborated.
Sections du résumé
BACKGROUND
Prebiotics is a relatively neglected area in cancer research, despite evidence suggesting that it plays a key role in suppressing tumour growth and improving immune function.
RECENT FINDINGS
Including prebiotics in the diet has been shown to strengthen the immune system and can better slow down or prevent the growth of tumours. It has also been strongly indicated in various scientific studies that prebiotics can contribute to the sustenance of a healthy microbiome, which in turn plays an important role in increasing the effectiveness and reducing the side effects of cancer treatments.
CONCLUSION
In the present review article we highlight the mechanisms by which prebiotics like inulin, fructooligosaccharide (FOS), β-glucan, pectin, and xylooligosaccharide (XOS) function. Furthermore, the beneficial effect of incorporating prebiotics during cancer therapy to improvise gut health and prevent/reverse the damage caused to patients due to chemotherapy has also been elaborated.
Identifiants
pubmed: 37458148
doi: 10.1002/cnr2.1870
pmc: PMC10644333
doi:
Substances chimiques
Prebiotics
0
Inulin
9005-80-5
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1870Informations de copyright
© 2023 The Authors. Cancer Reports published by Wiley Periodicals LLC.
Références
Int J Environ Res Public Health. 2020 Oct 19;17(20):
pubmed: 33086688
Gut Microbes. 2013 May-Jun;4(3):181-92
pubmed: 23511582
Gastroenterol Clin North Am. 1996 Dec;25(4):773-91
pubmed: 8960892
Integr Cancer Ther. 2018 Dec;17(4):1225-1234
pubmed: 30043669
Carbohydr Res. 2008 Oct 13;343(15):2589-94
pubmed: 18703180
J Funct Foods. 2015 Jan;12:92-108
pubmed: 25584074
Carcinogenesis. 2002 Nov;23(11):1953-60
pubmed: 12419846
Front Immunol. 2023 Feb 17;14:1104224
pubmed: 36875124
J Natl Cancer Inst. 1991 Mar 6;83(5):355-8
pubmed: 1759994
Integr Cancer Ther. 2021 Jan-Dec;20:15347354211061733
pubmed: 34844479
Carcinogenesis. 1992 Sep;13(9):1509-12
pubmed: 1394832
Am J Physiol. 1991 Feb;260(2 Pt 1):C183-93
pubmed: 1996606
Cell Rep. 2020 Feb 11;30(6):1753-1766.e6
pubmed: 32049008
Foods. 2019 Mar 09;8(3):
pubmed: 30857316
Microorganisms. 2021 Jun 18;9(6):
pubmed: 34207094
Dig Dis Sci. 2020 Mar;65(3):874-884
pubmed: 32026181
J Appl Microbiol. 2020 May;128(5):1486-1496
pubmed: 31834648
Crit Rev Food Sci Nutr. 2016;56(6):946-56
pubmed: 25162145
Anticancer Agents Med Chem. 2022;22(4):605-628
pubmed: 33305713
Reprod Nutr Dev. 2003 Jul-Aug;43(4):347-56
pubmed: 14971826
Gut. 2022 Jul;71(7):1412-1425
pubmed: 35277453
Biochem J. 2004 Dec 1;384(Pt 2):307-16
pubmed: 15361072
J Physiol Biochem. 2009 Sep;65(3):315-28
pubmed: 20119826
J Ind Microbiol Biotechnol. 2019 Oct;46(9-10):1445-1459
pubmed: 31201649
Br J Nutr. 2005 Apr;93 Suppl 1:S41-8
pubmed: 15877894
Euroasian J Hepatogastroenterol. 2018 Jan-Jun;8(1):11-17
pubmed: 29963455
Nutrients. 2013 Apr 22;5(4):1417-35
pubmed: 23609775
Gut Microbes. 2012 Jan-Feb;3(1):4-14
pubmed: 22356853
Nutr Rev. 2012 Aug;70(8):436-43
pubmed: 22835137
Results Pharma Sci. 2012 May 22;2:38-45
pubmed: 25755993
Obes Res. 2002 Dec;10 Suppl 2:116S-123S
pubmed: 12490660
Int J Microbiol. 2020 Jun 12;2020:8045646
pubmed: 32612660
Oncogene. 2020 Jun;39(26):4925-4943
pubmed: 32514151
Molecules. 2021 Feb 22;26(4):
pubmed: 33671813
J Nutr Metab. 2012;2012:851362
pubmed: 22187640
BMC Cancer. 2019 Dec 23;19(1):1243
pubmed: 31870331
SAGE Open Med. 2021 Aug 12;9:20503121211034366
pubmed: 34408877
Cancer Rep (Hoboken). 2023 Nov;6(11):e1870
pubmed: 37458148
Cancer Cell. 2021 Oct 11;39(10):1317-1341
pubmed: 34506740
J Nutr. 1995 Jun;125(6):1401-12
pubmed: 7782892
Oncol Nurs Forum. 2015 May;42(3):E269-78
pubmed: 25901389
Br J Nutr. 2002 May;87 Suppl 2:S283-6
pubmed: 12088530
Glycobiology. 2007 Aug;17(8):805-19
pubmed: 17513886
J Nutr. 2006 Jan;136(1):70-4
pubmed: 16365061
Int J Cancer. 2021 Aug 1;149(3):494-504
pubmed: 33521932
Br J Cancer. 1995 Apr;71(4):763-9
pubmed: 7710942
J Korean Med Sci. 2006 Oct;21(5):781-9
pubmed: 17043406
Pak J Med Sci. 2019 Mar-Apr;35(2):575-580
pubmed: 31086553
Immunol Rev. 2009 Jul;230(1):38-50
pubmed: 19594628
Eur J Nutr. 2009 Dec;48(8):457-64
pubmed: 19575258
Front Pharmacol. 2013 Oct 08;4:128
pubmed: 24115933
Trends Microbiol. 2021 Aug;29(8):667-685
pubmed: 33551269
Cancer Discov. 2022 Jan;12(1):31-46
pubmed: 35022204
Immunol Cell Biol. 2021 Mar;99(3):255-273
pubmed: 32996638
Cardiovasc Ther. 2019 Jul 01;2019:5707150
pubmed: 31772611
Curr Opin Biotechnol. 2016 Feb;37:1-7
pubmed: 26431716
Cancers (Basel). 2022 May 31;14(11):
pubmed: 35681702
Br J Nutr. 2005 Apr;93 Suppl 1:S73-90
pubmed: 15877900
Microb Ecol. 2014 Apr;67(3):690-9
pubmed: 24402367
Gastroenterology. 1998 Mar;114(3):441-7
pubmed: 9496933