Understanding the neurological implications of acute and long COVID using brain organoids.
Brain organoids
Long COVID
Neurological affectations
SARS-CoV-2
Journal
Disease models & mechanisms
ISSN: 1754-8411
Titre abrégé: Dis Model Mech
Pays: England
ID NLM: 101483332
Informations de publication
Date de publication:
01 07 2023
01 07 2023
Historique:
medline:
18
7
2023
pubmed:
17
7
2023
entrez:
17
7
2023
Statut:
ppublish
Résumé
As early as in the acute phase of the coronavirus disease 2019 (COVID-19) pandemic, the research community voiced concerns about the long-term implications of infection. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), like many other viruses, can trigger chronic disorders that last months or even years. Long COVID, the chronic and persistent disorder lasting more than 12 weeks after the primary infection with SARS-CoV-2, involves a variable number of neurological manifestations, ranging from mild to severe and even fatal. In vitro and in vivo modeling suggest that SARS-CoV-2 infection drives changes within neurons, glia and the brain vasculature. In this Review, we summarize the current understanding of the neuropathology of acute and long COVID, with particular emphasis on the knowledge derived from brain organoid models. We highlight the advantages and main limitations of brain organoids, leveraging their human-derived origin, their similarity in cellular and tissue architecture to human tissues, and their potential to decipher the pathophysiology of long COVID.
Identifiants
pubmed: 37458167
pii: 323961
doi: 10.1242/dmm.050049
pmc: PMC10387352
pii:
doi:
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing or financial interests.
Références
Ann Clin Transl Neurol. 2022 Jul;9(7):995-1010
pubmed: 35702954
Nature. 2021 Oct;598(7880):342-347
pubmed: 34464958
Alzheimers Dement. 2021 Aug;17(8):1297-1306
pubmed: 33559975
Cell Stem Cell. 2019 Oct 3;25(4):558-569.e7
pubmed: 31474560
Immunity. 2021 Jan 12;54(1):164-175.e6
pubmed: 33382973
Dis Model Mech. 2021 Jun 1;14(6):
pubmed: 34219165
EClinicalMedicine. 2021 Aug;38:101019
pubmed: 34308300
Acta Neuropathol. 2020 Jul;140(1):1-6
pubmed: 32449057
Lancet Infect Dis. 2021 Jan;21(1):52-58
pubmed: 33058797
Nat Commun. 2022 Nov 9;13(1):6777
pubmed: 36351919
Cell Rep. 2020 Jul 7;32(1):107863
pubmed: 32610043
Science. 2016 May 13;352(6287):816-8
pubmed: 27064148
J Neuroinflammation. 2022 Jan 20;19(1):19
pubmed: 35057809
EMBO J. 2020 Oct 15;39(20):e106230
pubmed: 32876341
Front Public Health. 2021 Sep 09;9:738423
pubmed: 34568267
JAMA Neurol. 2022 May 1;79(5):509-517
pubmed: 35258587
Lancet Psychiatry. 2021 May;8(5):416-427
pubmed: 33836148
Stem Cell Reports. 2020 Jul 14;15(1):256-273
pubmed: 32589876
Nat Commun. 2021 Nov 16;12(1):6610
pubmed: 34785679
Science. 2020 Nov 13;370(6518):856-860
pubmed: 33082293
Viruses. 2021 Jan 19;13(1):
pubmed: 33477869
Dis Model Mech. 2022 May 1;15(5):
pubmed: 35438176
Children (Basel). 2022 Oct 31;9(11):
pubmed: 36360405
Cortex. 2022 Sep;154:212-230
pubmed: 35780756
Nat Med. 2021 Apr;27(4):626-631
pubmed: 33692530
Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2122236119
pubmed: 35858406
Cell Res. 2021 Feb;31(2):126-140
pubmed: 33420426
J Virol. 2022 Apr 27;96(8):e0012822
pubmed: 35343766
Nature. 2022 Dec;612(7941):758-763
pubmed: 36517603
Ann Intern Med. 2022 Jul;175(7):969-979
pubmed: 35605238
Mol Cell. 2020 May 21;78(4):779-784.e5
pubmed: 32362314
EMBO J. 2021 Mar 1;40(5):e105912
pubmed: 33283287
Nature. 2020 Oct;586(7830):509-515
pubmed: 32967005
Neurology. 2020 Sep 22;95(12):e1754-e1759
pubmed: 32546655
Neurology. 2021 Jan 12;96(2):e294-e300
pubmed: 33004602
PLoS One. 2021 Jun 23;16(6):e0253347
pubmed: 34161337
Development. 2022 Oct 15;149(20):
pubmed: 36317797
Nat Med. 2021 Sep;27(9):1607-1613
pubmed: 34163090
Cell. 2022 Jul 7;185(14):2452-2468.e16
pubmed: 35768006
Cell. 2020 Oct 1;183(1):16-27.e1
pubmed: 32882182
Viruses. 2019 Dec 20;12(1):
pubmed: 31861926
Sci Rep. 2019 Oct 30;9(1):15663
pubmed: 31666641
Stem Cell Reports. 2021 Mar 9;16(3):437-445
pubmed: 33631122
Cells. 2022 Oct 13;11(20):
pubmed: 36291083
Science. 2020 Nov 13;370(6518):861-865
pubmed: 33082294
Stem Cell Reports. 2021 May 11;16(5):1156-1164
pubmed: 33979600
Science. 2022 Jan 21;375(6578):296-301
pubmed: 35025605
Cell. 2016 Jun 16;165(7):1586-1597
pubmed: 27315476
Nat Protoc. 2014 Oct;9(10):2329-40
pubmed: 25188634
J Biol Chem. 2021 Jan-Jun;296:100306
pubmed: 33476648
J Neurochem. 2022 Apr;161(2):146-157
pubmed: 35137414
Adv Virus Res. 2011;79:165-202
pubmed: 21601048
CNS Neurol Disord Drug Targets. 2022;21(10):1017-1026
pubmed: 35021982
Elife. 2021 Apr 09;10:
pubmed: 33835028
Immunity. 2021 Jul 13;54(7):1594-1610.e11
pubmed: 34174183
Eur Arch Otorhinolaryngol. 2020 Aug;277(8):2251-2261
pubmed: 32253535
Front Pediatr. 2022 May 11;10:894204
pubmed: 35633949
Mol Psychiatry. 2018 Dec;23(12):2363-2374
pubmed: 30171212
Cells. 2021 Oct 14;10(10):
pubmed: 34685735
Sci Transl Med. 2022 Sep 28;14(664):eabq3059
pubmed: 35857629
EMBO J. 2019 Feb 15;38(4):
pubmed: 30643021
Cell. 2022 May 26;185(11):1837-1839
pubmed: 35623327
Brain Behav Immun. 2021 May;94:138-147
pubmed: 33639239
J Exp Med. 2021 Mar 1;218(3):
pubmed: 33433624
PLoS Biol. 2022 Nov 3;20(11):e3001845
pubmed: 36327326
Nat Med. 2022 Nov;28(11):2406-2415
pubmed: 36138154
Cell Host Microbe. 2020 Jul 8;28(1):124-133.e4
pubmed: 32485164
Lancet. 2021 Jan 16;397(10270):220-232
pubmed: 33428867
J Infect. 2021 Aug;83(2):e6-e8
pubmed: 34147529
Lancet Infect Dis. 2022 Apr;22(4):e102-e107
pubmed: 34951953
Biochem Biophys Res Commun. 2021 Oct 8;573:158-163
pubmed: 34416436
Brain Behav Immun. 2020 Jul;87:122-123
pubmed: 32360606
Nature. 2022 Apr;604(7907):697-707
pubmed: 35255491
J Mol Biol. 2022 Feb 15;434(3):167386
pubmed: 34883115
Nature. 2021 Jul;595(7868):482-483
pubmed: 34262190
EMBO J. 2021 Aug 16;40(16):e107821
pubmed: 34159616
Nature. 2020 May;581(7807):221-224
pubmed: 32225175
J Infect. 2020 May;80(5):e14-e17
pubmed: 32171867
J Med Virol. 2020 Jul;92(7):699-702
pubmed: 32314810
Nature. 2021 Oct;598(7879):205-213
pubmed: 34616060
Cell Stem Cell. 2022 Feb 3;29(2):217-231.e8
pubmed: 35032430
Neurol Sci. 2021 Dec;42(12):4903-4907
pubmed: 34523082
J Virol. 2020 Mar 17;94(7):
pubmed: 31996437
Cell Stem Cell. 2020 Dec 3;27(6):937-950.e9
pubmed: 33010822
iScience. 2022 Oct 21;25(10):105146
pubmed: 36128218
Nat Neurosci. 2021 Feb;24(2):168-175
pubmed: 33257876
Med Image Anal. 2021 Jul;71:102054
pubmed: 33932751
Front Immunol. 2022 Apr 11;13:866153
pubmed: 35479062
Brain. 2021 May 7;144(4):1263-1276
pubmed: 33822001
Cell Stem Cell. 2017 Mar 2;20(3):397-406.e5
pubmed: 28132835
Nat Med. 2020 Jul;26(7):1077-1083
pubmed: 32405028
Ocul Surf. 2021 Jan;19:190-200
pubmed: 32502616
JAMA. 2020 Aug 11;324(6):603-605
pubmed: 32644129
J Laryngol Otol. 2021 Sep;135(9):839-843
pubmed: 34348821
Nat Med. 2022 Jul;28(7):1461-1467
pubmed: 35614233
Dis Model Mech. 2022 Nov 1;15(11):
pubmed: 36222118
Nat Genet. 2013 Jun;45(6):580-5
pubmed: 23715323
Eur J Neurol. 2022 Apr;29(4):1218-1221
pubmed: 34918425
Brain Pathol. 2021 Mar;31(2):385-386
pubmed: 33098141
Pathogens. 2021 Jun 17;10(6):
pubmed: 34204243
PLoS Pathog. 2022 Sep 7;18(9):e1010741
pubmed: 36070309
J Gerontol A Biol Sci Med Sci. 2020 Oct 15;75(11):2231-2232
pubmed: 32451547
EClinicalMedicine. 2021 Apr;34:100839
pubmed: 33898952
Brain Behav Immun. 2020 Oct;89:594-600
pubmed: 32738287
JAMA Netw Open. 2021 Oct 1;4(10):e2130645
pubmed: 34677597
Nat Commun. 2022 Jun 28;13(1):3528
pubmed: 35764621
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11727-11734
pubmed: 32376634
Viruses. 2020 Sep 08;12(9):
pubmed: 32911874
Value Health. 2023 Jun;26(6):934-942
pubmed: 36436792
Nat Med. 2022 May;28(5):911-923
pubmed: 35585196
J Alzheimers Dis. 2020;78(4):1367-1372
pubmed: 33074239
Brain Sci. 2022 Jan 24;12(2):
pubmed: 35203918
J Infect. 2020 Dec;81(6):e4-e6
pubmed: 32853602
Acta Neuropsychiatr. 2022 Jun;34(3):109-126
pubmed: 35144718
World J Gastroenterol. 2022 Jan 21;28(3):275-289
pubmed: 35110950
Science. 2014 Jul 18;345(6194):1247125
pubmed: 25035496
Nature. 2017 May 4;545(7652):48-53
pubmed: 28445462
Lancet Neurol. 2020 Nov;19(11):919-929
pubmed: 33031735
Nat Biotechnol. 2014 Aug;32(8):760-72
pubmed: 25093883
Cell Rep Med. 2020 Jul 21;1(4):100052
pubmed: 32835305
Neurology. 2020 Sep 29;95(13):559-560
pubmed: 32788251
Adv Sci (Weinh). 2021 Sep;8(18):e2101462
pubmed: 34337898
Clin Microbiol Infect. 2021 Jan;27(1):89-95
pubmed: 32979574
Science. 2020 Jul 10;369(6500):
pubmed: 32527923
Med J Islam Repub Iran. 2020 Jun 15;34:62
pubmed: 32974228
Nature. 2019 Jun;570(7762):523-527
pubmed: 31168097
Eur Neuropsychopharmacol. 2021 May;46:39-48
pubmed: 33823427
Viral Immunol. 2000;13(3):255-67
pubmed: 11016591
J Neurol. 2022 Jan;269(1):44-46
pubmed: 34143277
Neuron. 2020 Jan 8;105(1):150-164.e6
pubmed: 31753579
Cell Stem Cell. 2020 Jul 2;27(1):125-136.e7
pubmed: 32579880
STAR Protoc. 2022 Dec 16;3(4):101872
pubmed: 36595951
JAMA. 2022 Oct 25;328(16):1604-1615
pubmed: 36215063
Nat Protoc. 2018 Mar;13(3):565-580
pubmed: 29470464
J Neurol Sci. 2022 Jan 15;432:120061
pubmed: 34894422
Eur J Nucl Med Mol Imaging. 2021 Aug;48(9):2823-2833
pubmed: 33501506
Nat Neurosci. 2021 Nov;24(11):1522-1533
pubmed: 34675436
Stem Cell Reports. 2022 Feb 8;17(2):307-320
pubmed: 35063125
PLoS Pathog. 2021 Nov 19;17(11):e1009743
pubmed: 34797899
Front Neurol. 2021 Oct 29;12:753284
pubmed: 34777224
Signal Transduct Target Ther. 2020 Dec 4;5(1):283
pubmed: 33277466
Cell Stem Cell. 2021 Feb 4;28(2):331-342.e5
pubmed: 33450186
Stem Cell Reports. 2021 Aug 10;16(8):1923-1937
pubmed: 34297942
Acta Paediatr. 2021 Jul;110(7):2208-2211
pubmed: 33835507
Cell Stem Cell. 2020 Dec 3;27(6):951-961.e5
pubmed: 33113348
Eur J Nucl Med Mol Imaging. 2022 Jul;49(9):3197-3202
pubmed: 35320385
Acta Neuropathol Commun. 2020 Aug 26;8(1):147
pubmed: 32847628
Cell Stem Cell. 2008 Nov 6;3(5):519-32
pubmed: 18983967
Lancet Child Adolesc Health. 2021 Mar;5(3):167-177
pubmed: 33338439
Nat Rev Neurol. 2021 Feb;17(2):69-70
pubmed: 33408384
Nat Protoc. 2019 Feb;14(2):518-540
pubmed: 30664680
Fed Pract. 2020 Sep;37(9):398-404
pubmed: 33029064
Dis Model Mech. 2020 Sep 1;13(9):
pubmed: 32887790
Nat Med. 2022 Aug;28(8):1706-1714
pubmed: 35879616
ALTEX. 2020 Jun 26;37(4):665-671
pubmed: 32591839
Nat Med. 2020 Jul;26(7):1017-1032
pubmed: 32651579
Nature. 2021 Jan;589(7841):270-275
pubmed: 33116299
Eur J Neurol. 2021 Nov;28(11):3820-3825
pubmed: 34327787
Nat Commun. 2020 Mar 27;11(1):1620
pubmed: 32221306
Cell Res. 2020 Oct;30(10):928-931
pubmed: 32753756
EBioMedicine. 2022 Apr;78:103981
pubmed: 35390636
Brain Behav Immun Health. 2021 Aug;15:100282
pubmed: 34124700
J Clin Invest. 2021 Apr 15;131(8):
pubmed: 33630760
Nature. 2020 Dec;588(7836):22-24
pubmed: 33268868
Cell. 2021 Apr 15;184(8):2212-2228.e12
pubmed: 33713620
JCI Insight. 2022 Feb 22;7(4):
pubmed: 35191397
Stem Cells Int. 2021 Sep 9;2021:5902824
pubmed: 34539790
Alzheimers Dement. 2021 Jun;17(6):1056-1065
pubmed: 33399270
Front Immunol. 2021 Apr 28;12:589095
pubmed: 33995341
Signal Transduct Target Ther. 2021 Sep 6;6(1):337
pubmed: 34489403
Nat Neurosci. 2021 Mar;24(3):368-378
pubmed: 33328624
BMC Health Serv Res. 2020 Dec 20;20(1):1144
pubmed: 33342437
J Gerontol A Biol Sci Med Sci. 2020 Oct 15;75(11):2224-2230
pubmed: 32687551
Front Med (Lausanne). 2020 Aug 20;7:531
pubmed: 32974374
Nat Med. 2021 Sep;27(9):1600-1606
pubmed: 34244682
Alzheimers Res Ther. 2020 Jun 4;12(1):69
pubmed: 32498691
Histopathology. 2020 Aug;77(2):186-197
pubmed: 32443177
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Mol Psychiatry. 2022 Oct;27(10):3939-3950
pubmed: 36198765
Nat Rev Microbiol. 2023 Mar;21(3):133-146
pubmed: 36639608
Science. 2020 Jul 3;369(6499):50-54
pubmed: 32358202
PLoS One. 2021 Feb 16;16(2):e0247205
pubmed: 33592063
Cell. 2020 May 14;181(4):905-913.e7
pubmed: 32333836
Cells. 2022 Sep 08;11(18):
pubmed: 36139380
Eur J Intern Med. 2020 Jun;76:14-20
pubmed: 32336612
Nat Med. 2021 Apr;27(4):601-615
pubmed: 33753937
Cell. 2021 Apr 15;184(8):2167-2182.e22
pubmed: 33811809
Nature. 2020 May;581(7807):215-220
pubmed: 32225176
Cell Rep Med. 2021 May 18;2(5):100288
pubmed: 33969321
Nat Rev Immunol. 2021 Nov;21(11):704-717
pubmed: 33911232
Nature. 2021 Jul;595(7868):565-571
pubmed: 34153974
Life Sci Alliance. 2020 Jul 23;3(9):
pubmed: 32703818
Circ J. 2020 Oct 23;84(11):2027-2031
pubmed: 32981925
N Engl J Med. 2020 Apr 23;382(17):1653-1659
pubmed: 32227760
Eur Heart J. 2022 Mar 14;43(11):1124-1137
pubmed: 34999762