Lysyl oxidase like-2 in fibrosis and cardiovascular disease.
LOXL2
aging
cardiovascular
fibrosis
Journal
American journal of physiology. Cell physiology
ISSN: 1522-1563
Titre abrégé: Am J Physiol Cell Physiol
Pays: United States
ID NLM: 100901225
Informations de publication
Date de publication:
01 09 2023
01 09 2023
Historique:
pmc-release:
01
09
2024
medline:
1
9
2023
pubmed:
17
7
2023
entrez:
17
7
2023
Statut:
ppublish
Résumé
Fibrosis is an important and essential reparative response to injury that, if left uncontrolled, results in the excessive synthesis, deposition, remodeling, and stiffening of the extracellular matrix, which is deleterious to organ function. Thus, the sustained activation of enzymes that catalyze matrix remodeling and cross linking is a fundamental step in the pathology of fibrotic diseases. Recent studies have implicated the amine oxidase lysyl oxidase like-2 (LOXL2) in this process and established significantly elevated expression of LOXL2 as a key component of profibrotic conditions in several organ systems. Understanding the relationship between LOXL2 and fibrosis as well as the mechanisms behind these relationships can offer significant insights for developing novel therapies. Here, we summarize the key findings that demonstrate the link between LOXL2 and fibrosis and inflammation, examine current therapeutics targeting LOXL2 for the treatment of fibrosis, and discuss future directions for experiments and biomedical engineering.
Identifiants
pubmed: 37458436
doi: 10.1152/ajpcell.00176.2023
pmc: PMC10635644
doi:
Substances chimiques
Protein-Lysine 6-Oxidase
EC 1.4.3.13
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
C694-C707Subventions
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : R01HL148112
Références
Int J Mol Sci. 2021 Jan 20;22(3):
pubmed: 33498156
Int Urol Nephrol. 2020 Jul;52(7):1287-1295
pubmed: 32378138
J Clin Invest. 2014 Apr;124(4):1622-35
pubmed: 24590289
Gut. 2017 Sep;66(9):1697-1708
pubmed: 28073888
Hematol Oncol. 2018 Oct;36(4):701-708
pubmed: 30105794
Nat Med. 2010 Sep;16(9):1009-17
pubmed: 20818376
Oncogene. 2005 Nov 14;24(50):7443-54
pubmed: 16288291
Am J Pathol. 2008 Feb;172(2):309-20
pubmed: 18202198
Exp Mol Med. 2019 Feb 21;51(2):1-12
pubmed: 30804321
J Biol Chem. 2013 Oct 18;288(42):30000-30008
pubmed: 24014025
Development. 2015 Mar 1;142(5):983-93
pubmed: 25715398
Exp Ther Med. 2022 Sep 02;24(5):648
pubmed: 36168418
J Clin Invest. 2007 Dec;117(12):3810-20
pubmed: 18037992
Biochem Soc Trans. 2002 Apr;30(2):194-200
pubmed: 12023850
Genomics. 2001 Jun 1;74(2):211-8
pubmed: 11386757
Cardiovasc Res. 2016 Jan 1;109(1):67-78
pubmed: 26260798
Sci Rep. 2016 Jun 22;6:28149
pubmed: 27329825
Carcinogenesis. 2009 Oct;30(10):1660-9
pubmed: 19625348
Fibrogenesis Tissue Repair. 2012 Jun 06;5(Suppl 1):S16
pubmed: 23259746
JACC Basic Transl Sci. 2020 Jan 27;5(1):84-87
pubmed: 32043487
Front Med (Lausanne). 2022 May 16;9:866746
pubmed: 35652066
Mol Biol Cell. 2001 Sep;12(9):2730-41
pubmed: 11553712
J Biol Chem. 2001 May 18;276(20):17058-62
pubmed: 11279127
Blood. 2011 Oct 6;118(14):3979-89
pubmed: 21835952
Am J Pathol. 2012 Apr;180(4):1340-55
pubmed: 22387320
Int J Mol Sci. 2020 Aug 18;21(16):
pubmed: 32824630
Cancer Res. 2022 Mar 1;82(5):749-763
pubmed: 34911786
J Mol Cell Cardiol. 2014 May;70:9-18
pubmed: 24189039
Curr Rheumatol Rep. 2006 Apr;8(2):145-50
pubmed: 16569374
J Cell Biol. 2005 Jun 20;169(6):941-52
pubmed: 15967814
Biol Open. 2014 Feb 15;3(2):129-37
pubmed: 24414204
Biosci Rep. 2017 Nov 21;37(6):
pubmed: 29089463
Ann N Y Acad Sci. 2009 Oct;1177:57-65
pubmed: 19845607
Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15;304(6):G605-14
pubmed: 23328207
Cell Mol Life Sci. 2006 Oct;63(19-20):2304-16
pubmed: 16909208
J Am Coll Cardiol. 2014 Jun 3;63(21):2188-98
pubmed: 24657693
Cell Mol Life Sci. 2014 Feb;71(4):549-74
pubmed: 23649149
Eur Respir J. 2014 May;43(5):1430-8
pubmed: 24177001
Am J Hematol. 2018 Mar;93(3):430-441
pubmed: 29247535
Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2693-2707
pubmed: 34470477
Gastroenterology. 2018 Oct;155(4):1140-1153
pubmed: 29990488
Oncogenesis. 2017 Jul 3;6(7):e352
pubmed: 28671675
Commun Biol. 2023 Apr 7;6(1):375
pubmed: 37029269
Thorax. 2021 Jul;76(7):729-732
pubmed: 33472968
Sci Rep. 2018 Jul 18;8(1):10858
pubmed: 30022146
N Engl J Med. 2020 Mar 12;382(11):1068-1070
pubmed: 32160670
J Pathol. 2008 Jan;214(2):199-210
pubmed: 18161745
Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1446-58
pubmed: 24833797
J Infect Dis. 2010 Aug 15;202(3):416-26
pubmed: 20565256
J Heart Lung Transplant. 2008 Jun;27(6):589-96
pubmed: 18503956
Oncol Lett. 2018 Feb;15(2):2431-2440
pubmed: 29434955
EMBO J. 2005 Oct 5;24(19):3446-58
pubmed: 16096638
Mol Biol Rep. 2011 Jan;38(1):145-9
pubmed: 20306300
N Engl J Med. 2012 Mar 1;366(9):799-807
pubmed: 22375971
Mol Biol Cell. 2010 Jan 15;21(2):244-53
pubmed: 19923321
Am J Hematol. 2023 May;98(5):801-821
pubmed: 36680511
Front Immunol. 2012 Apr 10;3:71
pubmed: 22566952
J Crohns Colitis. 2018 Jun 28;12(7):849-859
pubmed: 29672662
Am J Physiol Gastrointest Liver Physiol. 2007 Dec;293(6):G1147-54
pubmed: 17932231
J Hematol Oncol. 2017 Feb 22;10(1):55
pubmed: 28228106
Sci Rep. 2020 Jul 23;10(1):12352
pubmed: 32703998
Nat Rev Cancer. 2012 Jul 19;12(8):540-52
pubmed: 22810810
Mol Med Rep. 2018 Feb;17(2):2431-2441
pubmed: 29207131
Hepatology. 2019 Dec;70(6):1913-1927
pubmed: 30993748
Am J Respir Cell Mol Biol. 2007 Jan;36(1):78-84
pubmed: 16858008
Eur Respir Rev. 2015 Mar;24(135):102-14
pubmed: 25726561
Angiology. 2019 Nov;70(10):896-907
pubmed: 31010298
Biomed Res Int. 2016;2016:2646212
pubmed: 27800489
J Clin Invest. 2007 Feb;117(2):482-91
pubmed: 17273560
Am J Physiol Renal Physiol. 2008 Oct;295(4):F1023-9
pubmed: 18667485
Am J Pathol. 2007 Jun;170(6):1807-16
pubmed: 17525249
J Cell Physiol. 2019 Jul;234(7):10260-10269
pubmed: 30387148
Dis Model Mech. 2011 Mar;4(2):165-78
pubmed: 21324931
Kidney Int. 2018 Aug;94(2):303-314
pubmed: 29759420
J Cell Mol Med. 2019 Mar;23(3):1759-1770
pubmed: 30536539
BMC Gastroenterol. 2018 May 8;18(1):60
pubmed: 29739329
J Biol Chem. 2010 Feb 26;285(9):6658-69
pubmed: 20026874
J Cell Biol. 2010 Aug 23;190(4):693-706
pubmed: 20733059
Cells. 2019 Nov 21;8(12):
pubmed: 31766500
J Clin Invest. 2009 Sep;119(9):2550-63
pubmed: 19652365
Exp Cell Res. 2005 Mar 10;304(1):16-27
pubmed: 15707570
Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L772-L782
pubmed: 28283478
Int J Mol Sci. 2019 Sep 27;20(19):
pubmed: 31569601
Invest Ophthalmol Vis Sci. 2011 Jul 15;52(8):5240-50
pubmed: 21546528
Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):401-410
pubmed: 28062500
Front Immunol. 2020 Mar 31;11:480
pubmed: 32296422
J Hematol Oncol. 2019 Aug 28;12(1):86
pubmed: 31462327
Invest Ophthalmol Vis Sci. 2013 Aug 27;54(8):5788-96
pubmed: 23821193
Am J Respir Crit Care Med. 2012 Nov 1;186(9):866-76
pubmed: 22936357
Am J Hematol. 2013 May;88(5):355-8
pubmed: 23494965
J Cell Biol. 2007 Dec 17;179(6):1311-23
pubmed: 18086923
PLoS One. 2014 Sep 12;9(9):e107055
pubmed: 25215577
Physiol Rep. 2020 Nov;8(22):e14631
pubmed: 33242364
Ann Plast Surg. 2008 Feb;60(2):194-7
pubmed: 18216515
Biochem Biophys Rep. 2018 Nov 30;17:38-43
pubmed: 30555938
Lancet. 2011 Dec 3;378(9807):1949-61
pubmed: 21719092
EMBO Mol Med. 2011 Sep;3(9):528-44
pubmed: 21732535
Curr Opin Nephrol Hypertens. 2004 May;13(3):279-84
pubmed: 15073485
Nat Commun. 2016 Dec 14;7:13710
pubmed: 27966531
Cancer Res. 2011 Mar 1;71(5):1561-72
pubmed: 21233336
Oncogene. 2017 Apr 6;36(14):1925-1938
pubmed: 27694892
J Drug Target. 2019 Aug;27(7):790-796
pubmed: 30457362
Front Immunol. 2020 Nov 26;11:599415
pubmed: 33324416
FASEB J. 2016 Apr;30(4):1599-609
pubmed: 26700732
Nat Rev Immunol. 2014 Mar;14(3):181-94
pubmed: 24566915
J Clin Invest. 2017 Oct 2;127(10):3675-3688
pubmed: 28872461
Hum Mol Genet. 2015 Nov 1;24(21):6174-85
pubmed: 26307084
J Med Chem. 2017 May 25;60(10):4403-4423
pubmed: 28471663
Cell Cycle. 2008 May 1;7(9):1128-32
pubmed: 18418042
Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H424-H433
pubmed: 29167120
Mol Cancer. 2019 Jan 31;18(1):18
pubmed: 30704479
Clin Pharmacol Ther. 1967 Jul-Aug;8(4):593-602
pubmed: 4951976
N Engl J Med. 2011 Feb 17;364(7):656-65
pubmed: 21323543
Clin Sci (Lond). 2017 Jun 7;131(12):1301-1315
pubmed: 28468951
Cell Cycle. 2005 Dec;4(12):1749-52
pubmed: 16294032
EMBO J. 2015 Apr 15;34(8):1090-109
pubmed: 25759215
Hepatology. 2019 Feb;69(2):684-698
pubmed: 30153359
Biochim Biophys Acta. 2003 Apr 11;1647(1-2):220-4
pubmed: 12686136
Cancer Cell. 2005 Sep;8(3):241-54
pubmed: 16169468
Arterioscler Thromb Vasc Biol. 2022 Oct;42(10):1254-1261
pubmed: 36004642
Int J Hematol. 2010 Mar;91(2):165-73
pubmed: 20186505
Int J Mol Sci. 2019 Apr 02;20(7):
pubmed: 30986934
Front Pharmacol. 2014 Jan 10;4:173
pubmed: 24454287
Br J Haematol. 2017 Mar;176(6):939-949
pubmed: 28220932
J Biol Chem. 2010 Jul 2;285(27):20964-74
pubmed: 20439985
Int Rev Cell Mol Biol. 2012;296:139-85
pubmed: 22559939
Liver Int. 2016 Dec;36(12):1783-1792
pubmed: 27232579
J Angiogenes Res. 2009 Sep 21;1:2
pubmed: 19946410
J Pharmacol Sci. 2018 Jan;136(1):31-38
pubmed: 29352658
Am J Pathol. 2005 Oct;167(4):927-36
pubmed: 16192629
Eur Respir J. 2022 Jul 7;60(1):
pubmed: 34996828
Gastroenterology. 2004 Jun;126(7):1795-808
pubmed: 15188175
Respiration. 2013;86(6):441-52
pubmed: 24356558
Transl Res. 2011 Oct;158(4):181-96
pubmed: 21925115
Am J Physiol Heart Circ Physiol. 2019 Jul 1;317(1):H49-H59
pubmed: 31002285
Lancet Respir Med. 2013 Jun;1(4):309-317
pubmed: 24429156
Am J Physiol Renal Physiol. 2005 Apr;288(4):F800-9
pubmed: 15536170
Sci Rep. 2017 Mar 23;7:44988
pubmed: 28332555
Mol Med Rep. 2017 Sep;16(3):2477-2482
pubmed: 28677767
Cerebrovasc Dis. 2022;51(2):188-198
pubmed: 34515064
Lancet Respir Med. 2017 Jan;5(1):22-32
pubmed: 27939076
Hepatology. 2020 Aug;72(2):729-741
pubmed: 32176358
Int J Biol Macromol. 2022 Jun 1;209(Pt A):563-575
pubmed: 35413319
Circ Res. 2010 Aug 6;107(3):418-28
pubmed: 20522804
Sci Rep. 2017 Dec;7(1):149
pubmed: 28273952
J Pathol. 2003 Jul;200(4):500-3
pubmed: 12845617
Lab Invest. 2017 Mar;97(3):232-242
pubmed: 27941755
Cancer Gene Ther. 2021 Sep;28(9):984-999
pubmed: 33712707
Cancer Res. 2011 Mar 1;71(5):1647-57
pubmed: 21239473
PLoS One. 2016 Apr 07;11(4):e0153101
pubmed: 27054717