Platelet mitochondria: the mighty few.
Journal
Current opinion in hematology
ISSN: 1531-7048
Titre abrégé: Curr Opin Hematol
Pays: United States
ID NLM: 9430802
Informations de publication
Date de publication:
01 09 2023
01 09 2023
Historique:
pmc-release:
01
09
2024
medline:
29
9
2023
pubmed:
17
7
2023
entrez:
17
7
2023
Statut:
ppublish
Résumé
Platelet mitochondrial dysfunction is both caused by, as well as a source of oxidative stress. Oxidative stress is a key hallmark of metabolic disorders such as dyslipidemia and diabetes, which are known to have higher risks for thrombotic complications. Increasing evidence supports a critical role for platelet mitochondria beyond energy production and apoptosis. Mitochondria are key regulators of reactive oxygen species and procoagulant platelets, which both contribute to pathological thrombosis. Studies targeting platelet mitochondrial pathways have reported promising results suggesting antithrombotic effects with limited impact on hemostasis in animal models. Targeting platelet mitochondria holds promise for the reduction of thrombotic complications in patients with metabolic disorders. Future studies should aim at validating these preclinical findings and translate them to the clinic.
Identifiants
pubmed: 37459354
doi: 10.1097/MOH.0000000000000772
pii: 00062752-990000000-00039
pmc: PMC10529105
mid: NIHMS1915442
doi:
Substances chimiques
Reactive Oxygen Species
0
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
167-174Subventions
Organisme : NIA NIH HHS
ID : K01 AG059892
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL160808
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL163019
Pays : United States
Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Références
Int J Mol Sci. 2022 Mar 27;23(7):
pubmed: 35409027
Front Cardiovasc Med. 2019 Oct 29;6:153
pubmed: 31737646
J Thromb Haemost. 2021 Sep;19(9):2256-2262
pubmed: 33724688
Redox Biol. 2022 Oct 11;57:102507
pubmed: 36244294
Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6825
pubmed: 26621721
Ann Am Thorac Soc. 2020 Jul;17(7):821-828
pubmed: 32187500
EMBO Mol Med. 2016 Jul 01;8(7):779-95
pubmed: 27221050
Transfusion. 2019 Jul;59(7):2403-2414
pubmed: 30973972
Nat Cardiovasc Res. 2022;1(8):732-747
pubmed: 35967457
Cell Rep. 2017 Jul 25;20(4):881-894
pubmed: 28746873
Cell Calcium. 2019 Jan;77:39-48
pubmed: 30530092
Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3564-73
pubmed: 26106157
Redox Biol. 2014 Jan 10;2:206-10
pubmed: 24494194
Sci Signal. 2009 Nov 17;2(97):ra73
pubmed: 19920251
BMC Biol. 2015 Oct 29;13:89
pubmed: 26515107
Blood. 1981 May;57(5):956-66
pubmed: 6260270
J Cell Biol. 1997 Jul 28;138(2):323-30
pubmed: 9230074
Science. 2001 Apr 20;292(5516):504-7
pubmed: 11283355
Circulation. 2019 Nov 19;140(21):1720-1733
pubmed: 31533452
Cell Mol Life Sci. 2014 Jul;71(14):2577-604
pubmed: 24363178
N Engl J Med. 2019 Jan 24;380(4):347-357
pubmed: 30415602
Platelets. 2014;25(4):239-45
pubmed: 23909711
J Clin Invest. 1966 Dec;45(12):1923-34
pubmed: 4959090
Thromb Haemost. 2021 Jul;121(7):900-912
pubmed: 33421964
Nature. 2014 Jan 16;505(7483):335-43
pubmed: 24429632
Circulation. 2014 Apr 15;129(15):1598-609
pubmed: 24474649
Int J Mol Sci. 2022 Nov 25;23(23):
pubmed: 36499064
Blood. 1970 Aug;36(2):159-68
pubmed: 5427451
J Clin Invest. 1967 Mar;46(3):409-17
pubmed: 6023775
J Thromb Thrombolysis. 2020 Jul;50(1):123-134
pubmed: 32409937
Diabetes. 2001 Jun;50(6):1491-4
pubmed: 11375352
Blood Adv. 2020 Jan 14;4(1):127-135
pubmed: 31917844
Blood Adv. 2018 Nov 13;2(21):2848-2861
pubmed: 30381401
Int J Cardiol. 2017 Sep 15;243:9-14
pubmed: 28747040
Blood. 2021 Mar 25;137(12):1658-1668
pubmed: 33027814
J Physiol. 2014 Mar 1;592(5):829-39
pubmed: 24366263
Haematologica. 2020 Mar;105(3):808-819
pubmed: 31289200
Circ Res. 2018 May 11;122(10):1460-1478
pubmed: 29748369
Eur J Clin Invest. 1994 Feb;24 Suppl 1:30-3
pubmed: 8013529
Cell. 2012 Oct 26;151(3):630-44
pubmed: 23101630
J Am Heart Assoc. 2023 May 16;12(10):e027764
pubmed: 37183872
Blood. 2014 Oct 2;124(14):2173-83
pubmed: 25082876
Elife. 2013 Jun 04;2:e00704
pubmed: 23755363
Biochemistry. 2012 Apr 10;51(14):2959-73
pubmed: 22443365
Nat Rev Mol Cell Biol. 2019 May;20(5):267-284
pubmed: 30626975
Front Physiol. 2020 Nov 11;11:541040
pubmed: 33262702
Diabetes. 2016 Nov;65(11):3482-3494
pubmed: 27554467
Nat Rev Mol Cell Biol. 2018 Nov;19(11):713-730
pubmed: 30143745
Nat Commun. 2022 May 19;13(1):2769
pubmed: 35589699
Blood. 2009 Jul 16;114(3):663-6
pubmed: 19387006
Mol Cell Biol. 2014 Aug;34(15):2890-902
pubmed: 24865966
Eur J Haematol. 1998 Nov;61(5):319-26
pubmed: 9855247
Cancer Res. 2021 Nov 1;81(21):5506-5522
pubmed: 34535458
Biol Chem. 2020 May 26;401(6-7):737-747
pubmed: 32061164
Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):467-71
pubmed: 15591217
Cardiovasc Diabetol. 2016 Mar 31;15:52
pubmed: 27036108
Circulation. 1995 Dec 1;92(11):3172-7
pubmed: 7586300
Blood. 2014 May 1;123(18):2864-72
pubmed: 24677541
PLoS One. 2018 Apr 30;13(4):e0196580
pubmed: 29709004
Diabetes. 2019 May;68(5):932-938
pubmed: 30765335
Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2946-55
pubmed: 23087357
Int J Mol Sci. 2020 Jul 09;21(14):
pubmed: 32660144
Free Radic Biol Med. 2008 Jul 15;45(2):158-66
pubmed: 18452718
J Am Heart Assoc. 2022 Oct 18;11(20):e027071
pubmed: 36250653
J Thromb Haemost. 2010 Jun;8(6):1343-52
pubmed: 20149081
J Thromb Haemost. 2021 Feb;19(2):536-546
pubmed: 33118271
FEBS Lett. 1979 Apr 15;100(2):286-90
pubmed: 37114
Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):1988-96
pubmed: 15374851
Am J Physiol Cell Physiol. 2021 Apr 1;320(4):C465-C482
pubmed: 33296287
Biochem Soc Trans. 2003 Dec;31(Pt 6):1143-51
pubmed: 14641014
Biochem Soc Trans. 2013 Feb 1;41(1):118-23
pubmed: 23356269
Biochem J. 1974 Nov;144(2):385-96
pubmed: 4462589
Biochim Biophys Acta. 2013 May;1833(5):1147-56
pubmed: 23376776
Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):2017-20
pubmed: 22701021
PLoS One. 2015 Apr 13;10(4):e0123597
pubmed: 25875958
Clin Epigenetics. 2015 Apr 16;7:44
pubmed: 25901189
Front Cardiovasc Med. 2020 Jul 10;7:118
pubmed: 32754618
Nat Med. 2007 Sep;13(9):1086-95
pubmed: 17721545
J Vasc Res. 2013;50(5):357-71
pubmed: 23887139
Blood. 2015 Oct 15;126(16):1952-64
pubmed: 26333777
Platelets. 2021 Oct 3;32(7):855-862
pubmed: 33600275
Haematologica. 2019 Apr;104(4):806-818
pubmed: 30381300
Redox Biol. 2018 Apr;14:126-130
pubmed: 28888895
J Thromb Haemost. 2023 Aug;21(8):2163-2174
pubmed: 37061131
Int J Mol Sci. 2022 Aug 16;23(16):
pubmed: 36012465
Am J Physiol Cell Physiol. 2022 Oct 1;323(4):C951-C958
pubmed: 35993516
Circulation. 2019 Mar 12;139(11):1384-1395
pubmed: 30586757
Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1628-1639
pubmed: 28663252
Cell Metab. 2021 Feb 2;33(2):283-299.e9
pubmed: 33400911
Blood Adv. 2018 Aug 14;2(15):2029-2038
pubmed: 30108111
J Thromb Haemost. 2018 Nov;16(11):2300-2314
pubmed: 30151891
Thromb Haemost. 2017 Feb 28;117(3):529-542
pubmed: 27975100
Lab Invest. 2013 Jun;93(6):690-700
pubmed: 23528848
Blood. 2008 Feb 1;111(3):1257-65
pubmed: 17989312
Sci Transl Med. 2021 Feb 17;13(581):
pubmed: 33597264
Curr Opin Hematol. 2019 Sep;26(5):357-365
pubmed: 31261174
Blood. 2015 Apr 23;125(17):2693-703
pubmed: 25710879
Arterioscler Thromb Vasc Biol. 2023 Jan;43(1):79-91
pubmed: 36325902
J Thromb Haemost. 2018 Nov;16(11):2315-2321
pubmed: 30179298
Blood. 2013 Mar 7;121(10):1850-7
pubmed: 23303820
Thromb Haemost. 2017 Oct 5;117(10):1859-1867
pubmed: 28771279
Blood. 2014 Apr 17;123(16):e37-45
pubmed: 24523238
J Clin Invest. 2011 Nov;121(11):4462-76
pubmed: 22005299
Nutr Metab (Lond). 2014 Feb 12;11(1):10
pubmed: 24520982
Blood Adv. 2020 Jan 14;4(1):154-164
pubmed: 31935287