More than just risk for Alzheimer's disease: APOE ε4's impact on the aging brain.
Alzheimer’s risk
blood–brain barrier
cognitive aging
inflammation
neuronal dysfunction
Journal
Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
09
03
2023
revised:
16
05
2023
accepted:
12
06
2023
medline:
18
8
2023
pubmed:
18
7
2023
entrez:
17
7
2023
Statut:
ppublish
Résumé
The apolipoprotein ε4 (APOE ε4) allele is most commonly associated with increased risk for late-onset Alzheimer's disease (AD). However, recent longitudinal studies suggest that these risks are overestimated; most ε4 carriers will not develop dementia in their lifetime. In this article, we review new evidence regarding the impact of APOE ε4 on cognition among healthy older adults. We discuss emerging work from animal models suggesting that ε4 impacts brain structure and function in multiple ways that may lead to age-related cognitive impairment, independent from AD pathology. We discuss the importance of taking an individualized approach in future studies by incorporating biomarkers and neuroimaging methods that may better disentangle the phenotypic influences of APOE ε4 on the aging brain from prodromal AD pathology.
Identifiants
pubmed: 37460334
pii: S0166-2236(23)00141-8
doi: 10.1016/j.tins.2023.06.003
pii:
doi:
Substances chimiques
Apolipoprotein E4
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
750-763Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.