AraC interacts with p75
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
17 07 2023
17 07 2023
Historique:
received:
22
04
2023
accepted:
11
07
2023
revised:
29
06
2023
medline:
19
7
2023
pubmed:
18
7
2023
entrez:
17
7
2023
Statut:
epublish
Résumé
Cytosine arabinoside (AraC) is one of the main therapeutic treatments for several types of cancer, including acute myeloid leukaemia. However, after a high-dose AraC chemotherapy regime, patients develop severe neurotoxicity and cell death in the central nervous system leading to cerebellar ataxia, dysarthria, nystagmus, somnolence and drowsiness. AraC induces apoptosis in dividing cells. However, the mechanism by which it leads to neurite degeneration and cell death in mature neurons remains unclear. We hypothesise that the upregulation of the death receptor p75
Identifiants
pubmed: 37460457
doi: 10.1038/s41419-023-05979-7
pii: 10.1038/s41419-023-05979-7
pmc: PMC10352303
doi:
Substances chimiques
Receptor, Nerve Growth Factor
0
Receptors, Nerve Growth Factor
0
Ngfr protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
440Informations de copyright
© 2023. The Author(s).
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