Altered brain dynamic in major depressive disorder: state and trait features.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
17 07 2023
17 07 2023
Historique:
received:
05
06
2023
accepted:
22
06
2023
revised:
21
06
2023
medline:
19
7
2023
pubmed:
18
7
2023
entrez:
17
7
2023
Statut:
epublish
Résumé
Temporal neural synchrony disruption can be linked to a variety of symptoms of major depressive disorder (MDD), including mood rigidity and the inability to break the cycle of negative emotion or attention biases. This might imply that altered dynamic neural synchrony may play a role in the persistence and exacerbation of MDD symptoms. Our study aimed to investigate the changes in whole-brain dynamic patterns of the brain functional connectivity and activity related to depression using the hidden Markov model (HMM) on resting-state functional magnetic resonance imaging (rs-fMRI) data. We compared the patterns of brain functional dynamics in a large sample of 314 patients with MDD (65.9% female; age (mean ± standard deviation): 35.9 ± 13.4) and 498 healthy controls (59.4% female; age: 34.0 ± 12.8). The HMM model was used to explain variations in rs-fMRI functional connectivity and averaged functional activity across the whole-brain by using a set of six unique recurring states. This study compared the proportion of time spent in each state and the average duration of visits to each state to assess stability between different groups. Compared to healthy controls, patients with MDD showed significantly higher proportional time spent and temporal stability in a state characterized by weak functional connectivity within and between all brain networks and relatively strong averaged functional activity of regions located in the somatosensory motor (SMN), salience (SN), and dorsal attention (DAN) networks. Both proportional time spent and temporal stability of this brain state was significantly associated with depression severity. Healthy controls, in contrast to the MDD group, showed proportional time spent and temporal stability in a state with relatively strong functional connectivity within and between all brain networks but weak averaged functional activity across the whole brain. These findings suggest that disrupted brain functional synchrony across time is present in MDD and associated with current depression severity.
Identifiants
pubmed: 37460460
doi: 10.1038/s41398-023-02540-0
pii: 10.1038/s41398-023-02540-0
pmc: PMC10352359
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
261Informations de copyright
© 2023. The Author(s).
Références
Neuropsychopharmacology. 2021 Jan;46(1):1-2
pubmed: 32919403
Front Neurosci. 2020 Mar 27;14:191
pubmed: 32292322
JAMA Psychiatry. 2022 Sep 1;79(9):879-888
pubmed: 35895072
Neuroimage. 2021 Apr 1;229:117713
pubmed: 33421594
Psychol Psychother. 2011 Jun;84(2):230-6
pubmed: 22903859
Neuroimage. 2018 Oct 15;180(Pt B):646-656
pubmed: 28669905
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2035-40
pubmed: 19188601
Int J Psychophysiol. 2011 Feb;79(2):118-26
pubmed: 20875462
JAMA Psychiatry. 2015 Dec;72(12):1163-4
pubmed: 26559143
Behav Res Methods. 2013 Dec;45(4):905-27
pubmed: 23519455
Sci Rep. 2017 Jun 8;7(1):3095
pubmed: 28596608
Acta Neurol Scand. 1995 May;91(5):335-45
pubmed: 7639062
Lancet Psychiatry. 2019 Apr;6(4):318-326
pubmed: 30904126
J Affect Disord. 2013 Nov;151(2):423-431
pubmed: 23890584
Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12827-12832
pubmed: 29087305
Nat Commun. 2019 Mar 4;10(1):1035
pubmed: 30833560
Neuroimage. 2014 Oct 15;100:471-80
pubmed: 24973603
Nat Neurosci. 2020 Nov;23(11):1421-1432
pubmed: 32989295
Psychol Med. 2023 Feb;53(3):823-832
pubmed: 34154683
Trends Neurosci. 2020 Sep;43(9):667-680
pubmed: 32682563
Sci Rep. 2017 Aug 17;7(1):8675
pubmed: 28819132
J Clin Psychol. 1999 Jan;55(1):117-28
pubmed: 10100838
Psychol Methods. 2012 Sep;17(3):399-417
pubmed: 22563845
Cereb Cortex. 2007 Oct;17(10):2235-44
pubmed: 17138596
Can J Psychiatry. 2014 Dec;59(12):649-54
pubmed: 25702365
Psychol Bull. 2015 Mar;141(2):311-363
pubmed: 25365763
Brain Connect. 2021 Dec;11(10):838-849
pubmed: 33514278
Arch Gen Psychiatry. 1988 Aug;45(8):742-7
pubmed: 3395203
Arch Gen Psychiatry. 1991 Sep;48(9):851-5
pubmed: 1929776
Neuroimage. 2018 Feb 1;166:400-424
pubmed: 29079522
Transl Psychiatry. 2021 Oct 7;11(1):511
pubmed: 34620830
Hum Brain Mapp. 2019 May;40(7):2212-2228
pubmed: 30664285
Hum Brain Mapp. 2020 Oct 15;41(15):4264-4287
pubmed: 32643845
Front Psychiatry. 2018 Jul 31;9:339
pubmed: 30108526
Neuroimage. 2019 Mar;188:14-25
pubmed: 30521950
Mol Psychiatry. 2020 May;25(5):1130-1140
pubmed: 31435001
Front Neural Circuits. 2020 Sep 18;14:570583
pubmed: 33071760
Med Image Anal. 2001 Jun;5(2):143-56
pubmed: 11516708
Commun Biol. 2018 Jun 7;1:62
pubmed: 30271944
Psychol Med. 2023 May;53(7):2923-2935
pubmed: 34870570
Neuroimage Clin. 2020;26:102163
pubmed: 31953148
Philos Trans A Math Phys Eng Sci. 2012 Dec 31;371(1984):20120222
pubmed: 23277612
Nat Rev Neurosci. 2017 Feb;18(2):115-126
pubmed: 28053326
JAMA Psychiatry. 2015 Jun;72(6):603-11
pubmed: 25785575
J Affect Disord. 2019 Feb 15;245:1032-1042
pubmed: 30699845
BMC Psychiatry. 2007 Jul 17;7:32
pubmed: 17634111
Cereb Cortex. 2018 Sep 1;28(9):3095-3114
pubmed: 28981612
Front Psychol. 2019 Feb 11;10:245
pubmed: 30804860
Am J Psychiatry. 2011 Jun;168(6):642-8
pubmed: 21362744
Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):9078-9083
pubmed: 30979801
Trends Neurosci. 2011 Jan;34(1):1-9
pubmed: 21067824
Hum Brain Mapp. 2015 Jul;36(7):2781-94
pubmed: 25872899
Hum Brain Mapp. 2016 Aug;37(8):2918-30
pubmed: 27120982
Front Psychiatry. 2022 Jul 26;13:973921
pubmed: 35958666
Nat Med. 2017 Jan;23(1):28-38
pubmed: 27918562
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7900-5
pubmed: 27357684
Neuropsychopharmacology. 2016 Jun;41(7):1822-30
pubmed: 26632990
Biol Psychiatry. 2020 Nov 1;88(9):678-686
pubmed: 32646651
Neuropsychopharmacology. 2021 Jan;46(1):156-175
pubmed: 32781460
Neurosci Biobehav Rev. 2019 Aug;103:267-304
pubmed: 31125635
Brain Topogr. 2019 Nov;32(6):926-942
pubmed: 31707621
Mol Neurobiol. 2020 Oct;57(10):4031-4044
pubmed: 32651757
Biol Psychiatry. 2015 Aug 15;78(4):224-30
pubmed: 25861700
Neuropsychopharmacology. 2009 Mar;34(4):932-43
pubmed: 18536699
Clin Neurophysiol. 2019 Nov;130(11):2096-2104
pubmed: 31541987
Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10341-6
pubmed: 24982140
Hum Brain Mapp. 2017 Jun;38(6):2939-2954
pubmed: 28345197
Front Neurosci. 2018 Aug 28;12:603
pubmed: 30210284
Dialogues Clin Neurosci. 2006;8(2):227-39
pubmed: 16889108
Commun Biol. 2019 Nov 18;2:421
pubmed: 31754651
Transl Psychiatry. 2022 Nov 17;12(1):484
pubmed: 36396622
Nat Commun. 2020 Oct 5;11(1):5004
pubmed: 33020473
Perspect Psychol Sci. 2008 Sep;3(5):400-24
pubmed: 26158958
Neuroimage. 2014 Jul 15;95:232-47
pubmed: 24657355
Neuroimage. 2014 Apr 15;90:449-68
pubmed: 24389422
J Neurophysiol. 2011 Sep;106(3):1125-65
pubmed: 21653723
Sci Rep. 2017 Jul 11;7(1):5135
pubmed: 28698644
Hum Psychopharmacol. 2004 Oct;19 Suppl 1:S9-S13
pubmed: 15378669
Neuroimage. 2013 Oct 15;80:360-78
pubmed: 23707587
Neurosci Lett. 2009 Oct 2;463(2):108-13
pubmed: 19632301
Hum Brain Mapp. 2022 Jul;43(10):3207-3220
pubmed: 35393717
Neuroimage Clin. 2018 May 22;20:128-152
pubmed: 30094163