Fatty acid metabolism changes in association with neurobehavioral deficits in animal models of fetal alcohol spectrum disorders.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
17 07 2023
17 07 2023
Historique:
received:
27
11
2022
accepted:
10
07
2023
medline:
19
7
2023
pubmed:
18
7
2023
entrez:
17
7
2023
Statut:
epublish
Résumé
Fetal alcohol spectrum disorders (FASD) show behavioral problems due to prenatal alcohol exposure (PAE). A previous study reports changes in gene expressions linked to fatty acid (FA) metabolism in the cerebral cortex of the PAE mouse model. We find an increase of palmitic acid and arachidonic acid in phospholipid in the cerebral cortex of PAE at postnatal day 30. The increase of palmitic acid is consistent with increase of the producing enzyme, Fasn (fatty acid synthase). Decrease of 26:6 FA is also consistent with the increase of the enzyme which uses 26:6 as a substrate for making very long chain FAs, Elovl4 (elongation of very long chain fatty acids protein 4). However, there is no increase in the elongated products. Rather, lipid droplets (LDs) accumulated in the brain. Although FA-associated metabolic measurements are not affected by PAE, the abundance of FA-related gut microbiota is altered. This suggests that the gut microbiome could serve as a tool to facilitate uncovering the brain pathophysiology of FASD and a potential target to mitigate neurobehavioral problems.
Identifiants
pubmed: 37460609
doi: 10.1038/s42003-023-05127-z
pii: 10.1038/s42003-023-05127-z
pmc: PMC10352263
doi:
Substances chimiques
Palmitic Acids
0
Fatty Acids
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
736Subventions
Organisme : NIAAA NIH HHS
ID : F31 AA027693
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090257
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA026272
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002378
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA025215
Pays : United States
Informations de copyright
© 2023. The Author(s).
Références
Front Behav Neurosci. 2018 Sep 07;12:201
pubmed: 30245618
J Neurodev Disord. 2020 Mar 12;12(1):9
pubmed: 32164522
J Neurochem. 1990 Feb;54(2):415-23
pubmed: 2299344
Sci Rep. 2017 Oct 19;7(1):13537
pubmed: 29051531
Compr Physiol. 2013 Jul;3(3):1191-212
pubmed: 23897684
BMC Pediatr. 2019 Dec 27;19(1):516
pubmed: 31881951
FASEB J. 2016 Nov;30(11):3658-3668
pubmed: 27468758
Sci Rep. 2015 Dec 03;5:17679
pubmed: 26631430
Nat Rev Neurosci. 2014 Dec;15(12):771-85
pubmed: 25387473
J Dev Behav Pediatr. 2014 Nov-Dec;35(9):598-609
pubmed: 25325756
Chem Phys Lipids. 2008 May;153(1):34-46
pubmed: 18359292
Brain Behav Immun. 2018 May;70:48-60
pubmed: 29471030
Can J Biochem Physiol. 1959 Aug;37(8):911-7
pubmed: 13671378
Prog Retin Eye Res. 2019 Mar;69:137-158
pubmed: 30982505
JCI Insight. 2019 Dec 19;4(24):
pubmed: 31751317
Front Neuroanat. 2017 May 01;11:38
pubmed: 28507511
Biomolecules. 2021 Mar 01;11(3):
pubmed: 33804345
Sci Rep. 2021 Jan 8;11(1):248
pubmed: 33420159
Am J Physiol Regul Integr Comp Physiol. 2007 May;292(5):R1926-33
pubmed: 17218436
Appl Environ Microbiol. 2009 Dec;75(23):7537-41
pubmed: 19801464
J Clin Invest. 2020 May 1;130(5):2252-2269
pubmed: 32202514
Neuropsychopharmacology. 2013 Sep;38(10):2027-34
pubmed: 23615664
Adv Nutr. 2013 May 01;4(3):311-2
pubmed: 23674797
Dis Model Mech. 2015 Jan;8(1):1-16
pubmed: 25561744
Front Physiol. 2017 Nov 08;8:902
pubmed: 29167646
Neuron. 2019 Mar 20;101(6):998-1002
pubmed: 30897366
Asian-Australas J Anim Sci. 2018 May;31(5):686-695
pubmed: 27221247
Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27646-27654
pubmed: 33060302
Ann Gastroenterol. 2015 Apr-Jun;28(2):203-209
pubmed: 25830558
J Psychiatr Res. 2018 Sep;104:130-136
pubmed: 30029052
Lipids Health Dis. 2020 May 19;19(1):97
pubmed: 32430016
Nat Rev Gastroenterol Hepatol. 2019 Aug;16(8):461-478
pubmed: 31123355
Behav Brain Res. 2015 Jun 1;286:201-11
pubmed: 25746516
Bioinformatics. 2014 Nov 1;30(21):3123-4
pubmed: 25061070
Bioinformatics. 2019 Sep 1;35(17):3055-3062
pubmed: 30657866
Environ Microbiome. 2020 May 18;15(1):11
pubmed: 33902725
Front Endocrinol (Lausanne). 2020 Jan 31;11:25
pubmed: 32082260
J Alzheimers Dis. 2018;63(4):1337-1346
pubmed: 29758946
Neurology. 2008 Mar 25;70(13):1004-9
pubmed: 18199832
Annu Rev Neurosci. 2017 Jul 25;40:21-49
pubmed: 28301775
Neuromolecular Med. 2015 Jun;17(2):178-91
pubmed: 25893743
Gut. 2020 Feb;69(2):283-294
pubmed: 31471351
Physiol Behav. 2008 Jul 5;94(4):540-4
pubmed: 18486160
Nat Neurosci. 2020 Apr;23(4):533-543
pubmed: 32203497
Biochim Biophys Acta Biomembr. 2017 Sep;1859(9 Pt B):1558-1572
pubmed: 28411170
Molecules. 2018 Aug 03;23(8):
pubmed: 30081476
Bull Exp Biol Med. 2017 Apr;162(6):734-737
pubmed: 28429209
Front Cell Neurosci. 2019 Sep 20;13:428
pubmed: 31616255
Nat Rev Mol Cell Biol. 2019 Mar;20(3):137-155
pubmed: 30523332
Cold Spring Harb Perspect Biol. 2015 Sep 01;7(9):a021683
pubmed: 26330521
J Lipid Res. 2012 Nov;53(11):2343-54
pubmed: 22949356
Toxicol Sci. 2012 Apr;126(2):506-14
pubmed: 22223485
Nat Neurosci. 2020 Feb;23(2):194-208
pubmed: 31959936
Arch Intern Med. 2003 Jul 14;163(13):1524-8
pubmed: 12860573
Alcohol Clin Exp Res. 2014 Sep;38(9):2502-8
pubmed: 25159809
Cell Host Microbe. 2020 Aug 12;28(2):201-222
pubmed: 32791113
J Am Coll Nutr. 2020 Mar-Apr;39(3):249-260
pubmed: 32240041
Sci Rep. 2016 Mar 31;6:23795
pubmed: 27029648
Clin Chem. 2015 Mar;61(3):523-32
pubmed: 25595440
Science. 2006 Mar 3;311(5765):1258-62
pubmed: 16513975
Prog Neuropsychopharmacol Biol Psychiatry. 2016 Nov 3;71:76-82
pubmed: 27346743
Arch Gen Psychiatry. 2007 Jan;64(1):97-106
pubmed: 17199059
Arch Gen Psychiatry. 2008 May;65(5):568-76
pubmed: 18458208
Transl Psychiatry. 2022 Jan 20;12(1):24
pubmed: 35058425
Int Rev Cell Mol Biol. 2018;337:83-110
pubmed: 29551163
PLoS Comput Biol. 2017 Nov 3;13(11):e1005752
pubmed: 29099853
Dev Cell. 2015 Mar 23;32(6):678-92
pubmed: 25752962
Mol Cell Biochem. 2018 May;442(1-2):187-201
pubmed: 28993959
Pediatrics. 2015 Nov;136(5):e1395-406
pubmed: 26482673
J Ind Microbiol Biotechnol. 2015 Sep;42(9):1217-24
pubmed: 26153502
Alcohol Clin Exp Res. 1990 Oct;14(5):662-9
pubmed: 2264594
Methods Cell Biol. 2013;116:213-26
pubmed: 24099295
Nature. 2020 Oct;586(7828):281-286
pubmed: 32968276
Sci Rep. 2021 Nov 5;11(1):21746
pubmed: 34741138
Cell Stem Cell. 2015 Oct 1;17(4):397-411
pubmed: 26321199
Brain Behav Immun Health. 2020 Oct 09;9:100155
pubmed: 34589897
Neurology. 2020 May 19;94(20):e2088-e2098
pubmed: 32358220
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12843-8
pubmed: 18728184
J Neurosci. 2007 Jun 6;27(23):6128-40
pubmed: 17553985
J Neurochem. 2004 Jun;89(6):1368-77
pubmed: 15189339
Front Nutr. 2020 Mar 11;7:17
pubmed: 32219095
J Infect Dis. 2014 Jan 15;209(2):203-15
pubmed: 23904297
J Dairy Sci. 2009 Feb;92(2):632-7
pubmed: 19164675
Chromatographia. 2016;79:1003-1012
pubmed: 27512157
Obes Facts. 2019;12(2):150-156
pubmed: 30865949
Cell Rep. 2020 Sep 15;32(11):108132
pubmed: 32937123
Int J Mol Sci. 2020 Sep 02;21(17):
pubmed: 32887215
Curr Trop Med Rep. 2014 Jun 1;1(2):81-87
pubmed: 25110633
Behav Brain Res. 2007 Jan 10;176(1):149-69
pubmed: 16950524
Metabolism. 2003 Apr;52(4):454-62
pubmed: 12701058
J Neurol Sci. 1980 Feb;45(1):129-34
pubmed: 7359162
Nat Commun. 2021 Dec 21;12(1):7362
pubmed: 34934077
J Alzheimers Dis. 2018;64(3):995-1007
pubmed: 29966194
Cell. 2013 Dec 19;155(7):1451-63
pubmed: 24315484
Alcohol Clin Exp Res. 2022 Apr;46(4):542-555
pubmed: 35102585
Alcohol Clin Exp Res. 2019 Aug;43(8):1727-1733
pubmed: 31166027
Lancet Neurol. 2019 Aug;18(8):760-770
pubmed: 31160204
Cell Metab. 2019 May 7;29(5):1061-1077.e8
pubmed: 30612898
Mol Neurobiol. 2015 Aug;52(1):734-40
pubmed: 25284351
Mol Neurobiol. 2018 Feb;55(2):1795-1813
pubmed: 29168048
Front Cell Infect Microbiol. 2012 Aug 09;2:104
pubmed: 22919693
Microbiome. 2019 Feb 19;7(1):28
pubmed: 30782206