Influential Factors in the Efficacy of Hemoporfin-Mediated Photodynamic Therapy for Port-wine Stains.
Hemoporfin
Photodynamic therapy
Port-wine stains
Journal
Lasers in medical science
ISSN: 1435-604X
Titre abrégé: Lasers Med Sci
Pays: England
ID NLM: 8611515
Informations de publication
Date de publication:
17 Jul 2023
17 Jul 2023
Historique:
received:
10
05
2023
accepted:
27
06
2023
medline:
19
7
2023
pubmed:
18
7
2023
entrez:
17
7
2023
Statut:
epublish
Résumé
Hemoporfin-mediated photodynamic therapy (HMME-PDT) is commonly used in the treatment of port-wine stains (PWS). However, the influential factors for the efficacy of the treatment are not well defined. This study intends to observe the influential factors for the efficacy of HMME-PDT in the treatment of port-wine stains (PWS). A total of 551 patients with PWS of head and neck was enrolled in this retrospective study. Further screening the patients of facial PWS, 484 patients were chosen. Patients were treated with HMME-PDT. All patients received 1~3 sessions of treatment with 2~3-month intervals. We photographed the lesions before each session and 2~3 months after the last session. Ages, sessions, lesion subtypes, and previous treatment history were related to the response of HMME-PDT (P =0.032, P<0.001, P=0.012, P=0.003 respectively). Treatment sessions were the independent factor correlated with efficacy after 3 sessions of treatment. Patients with no treatment history targeting PWS showed higher efficacy than those were treated with laser or other photodynamic treatment (P<0.05). The efficacy was higher by increasing the sessions of treatment. The efficacy was higher for lesion on maxillary prominence area and mandibular prominence area that on frontonasal prominence area and optic vesicle area (P<0.05). HMME-PDT is an effective in the treatment of PWS. Patients received no previous treatment for PWS, total treatment sessions and lesion on maxillary prominence area and mandibular prominence area are positive factors.
Identifiants
pubmed: 37460668
doi: 10.1007/s10103-023-03822-1
pii: 10.1007/s10103-023-03822-1
doi:
Substances chimiques
hematoporphyrin monomethyl ether
0
Photosensitizing Agents
0
Hematoporphyrins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
162Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.
Références
Tan W, Wang J, Zhou F et al (2017) Coexistence of Eph receptor B1 and ephrin B2 in port-wine stain endothelial progenitor cells contributes to clinicopathological vasculature dilatation. Br J Dermatol 177(6):1601–1611. https://doi.org/10.1111/bjd.15716
doi: 10.1111/bjd.15716
pubmed: 28599054
pmcid: 9375175
(CSSVA) C S F T S O V A (2019) Guidelines for the diagnosis and treatment of hemangiomas and vascular malformations. J Tissue Eng Recon Surg 15(05):277–317. https://doi.org/10.3969/j.issn.1673-0364.2019.05.001
doi: 10.3969/j.issn.1673-0364.2019.05.001
Zhang Y, Yang Y, Zhang Z et al (2019) Clinical study on hemoporfin Pdt for infant facial port-wine stains. Photodiagn Photodyn Ther 25:106–110. https://doi.org/10.1016/j.pdpdt.2018.09.012
doi: 10.1016/j.pdpdt.2018.09.012
Lee S-J, Kim HY, Kim BS et al (2012) Capillary malformation of port-wine stain: differentiation from early arteriovenous malformation by histopathological clues. Am J Dermatopathol 34(5):523–528. https://doi.org/10.1097/DAD.0b013e3181b76443
doi: 10.1097/DAD.0b013e3181b76443
pubmed: 21814130
Huang Y, Yang J, Sun L et al (2021) Efficacy of influential factors in hemoporfin-mediated photodynamic therapy for facial port-wine stains. J Dermatol 48(11):1700–1708. https://doi.org/10.1111/1346-8138.16094
doi: 10.1111/1346-8138.16094
pubmed: 34355416
Ding Fan CB, Yi J, Li Xie-Lun L, Yan YZ, Hong M (2021) Clinical observation of hematoporphyrin monomethyl ether photodynamic therapy for port-wine stains. J Clin Dermatol 50(04):196–201. https://doi.org/10.16761/j.cnki.1000-4963.2021.04.002
doi: 10.16761/j.cnki.1000-4963.2021.04.002
Lanigan SW, Cotterill JA (1989) Psychological disabilities amongst patients with port wine stains. Brit J Dermatol 121(2):209–215. https://doi.org/10.1111/j.1365-2133.1989.tb01800.x
doi: 10.1111/j.1365-2133.1989.tb01800.x
Nguyen V, Hochman M, Mihm MC et al (2019) The pathogenesis of port wine stain and Sturge Weber syndrome: complex interactions between genetic alterations and aberrant MAPK and PI3K activation. Int J Mol Sci 20(9). https://doi.org/10.3390/ijms20092243
Troilius A, Wrangsjö B, Ljunggren B (1998) Potential psychological benefits from early treatment of port-wine stains in children. Br J Dermatol 139(1):59–65. https://doi.org/10.1046/j.1365-2133.1998.02314.x
doi: 10.1046/j.1365-2133.1998.02314.x
pubmed: 9764149
Jasim ZF, Handley JM (2007) Treatment of pulsed dye laser–resistant port wine stain birthmarks. J Am Acad Dermatol 57(4):677–682. https://doi.org/10.1016/j.jaad.2007.01.019
doi: 10.1016/j.jaad.2007.01.019
pubmed: 17658196
Gao K, Huang Z, Yuan KH et al (2013) Side-by-side comparison of photodynamic therapy and pulsed-dye laser treatment of port-wine stain birthmarks. Brit J Dermatol 168(5):1040–1046. https://doi.org/10.1111/bjd.12130
doi: 10.1111/bjd.12130
Han Y, Ying H, Zhang X et al (2020) Retrospective study of photodynamic therapy for pulsed dye laser-resistant port-wine stains. J Dermatol 47(4):348–355. https://doi.org/10.1111/1346-8138.15238
doi: 10.1111/1346-8138.15238
pubmed: 32012364
Kelly KM, Kimel S, Smith T et al (2004) Combined photodynamic and photothermal induced injury enhances damage to in vivo model blood vessels. Lasers Surg Med: The Official J American Society for Laser Med Surg 34(5):407–413. https://doi.org/10.1002/lsm.20041
doi: 10.1002/lsm.20041
Gu Y, Liu F, Wang K et al (2001) A clinic analysis of 1216 cases of port wine stain treated by photodynamic therapy. Chinese J Laser Med (02):21–24. https://doi.org/10.13480/j.issn1003-9430.2001.02.008
doi: 10.13480/j.issn1003-9430.2001.02.008
Li DC, Nong X, Hu ZY et al (2020) Efficacy and related factors analysis in Hmme-PDT in the treatment of port wine stains. Photodiagn Photodyn 29:101649. https://doi.org/10.1016/j.pdpdt.2020.101649
doi: 10.1016/j.pdpdt.2020.101649
Mei Y, Xiao X, Fan L et al (2019) In vitro photodynamic therapy of endothelial cells using hematoporphyrin monomethyl ether (Hemoporfin): relevance to treatment of port wine stains. Photodiagnosis Photodyn Ther 27:268–275. https://doi.org/10.1016/j.pdpdt.2019.06.003
doi: 10.1016/j.pdpdt.2019.06.003
pubmed: 31185325
pmcid: 6708484
Wu Q, Tu P, Zhou G et al (2018) A dose-finding study for hemoporfin in photodynamic therapy for port-wine stain: a multicenter randomized double-blind phase II b trial. Photodermatol Photoimmunol Photomed 34(5):314–321. https://doi.org/10.1111/phpp.12384
doi: 10.1111/phpp.12384
pubmed: 29533491
Gu Y, Li J, Chen H et al (1992) A study of photodynamic therapy for port wine stains using chicken comb as a model. Chinese J Laser Med 1(2):81. https://doi.org/10.13480/j.issn1003-9430.1992.02.007
doi: 10.13480/j.issn1003-9430.1992.02.007
Zhao Y, Tu P, Zhou G et al (2016) Hemoporfin photodynamic therapy for port-wine stain: a randomized controlled trial. PLoS One 11(5):e0156219. https://doi.org/10.1371/journal.pone.0156219
doi: 10.1371/journal.pone.0156219
pubmed: 27227544
pmcid: 4881994
Waelchli R, Aylett SE, Robinson K et al (2014) New vascular classification of port-wine stains: improving prediction of Sturge-Weber risk. Brit J Dermatol 171(4):861–867. https://doi.org/10.1111/bjd.13203
doi: 10.1111/bjd.13203
Chen JK, Ghasri P, Aguilar G et al (2012) An overview of clinical and experimental treatment modalities for port wine stains. J Am Acad Dermatol 67(2):289–304. e29. https://doi.org/10.1016/j.jaad.2011.11.938
doi: 10.1016/j.jaad.2011.11.938
pubmed: 22305042
pmcid: 4143189
Li X, Diao P, Liu L et al (2022) Hematoporphyrin monomethyl ether photodynamic therapy for the treatment of Sturge–Weber syndrome and large segmental facial port-wine stain. Dermatol Ther 35(5):e15404. https://doi.org/10.1111/dth.15404
doi: 10.1111/dth.15404
pubmed: 35199900
Hagen SL, Grey KR, Korta DZ et al (2017) Quality of life in adults with facial port-wine stains. J Am Acad Dermatol 76(4):695–702. https://doi.org/10.1016/j.jaad.2016.10.039
doi: 10.1016/j.jaad.2016.10.039
pubmed: 27955934
Nguyen C, Yohn J, Huff C et al (1998) Facial port wine stains in childhood: prediction of the rate of improvement as a function of the age of the patient, size and location of the port wine stain and the number of treatments with the pulsed dye (585 nm) laser. Br J Dermatol 138(5):821–825. https://doi.org/10.1046/j.1365-2133.1998.02219.x
doi: 10.1046/j.1365-2133.1998.02219.x
pubmed: 9666828
Lu Y-G, Wu J-J, Yang Y-D et al (2010) Photodynamic therapy of port-wine stains. J Dermatol Treat 21(4):240–244. https://doi.org/10.1080/09546630903200604
doi: 10.1080/09546630903200604
Gu Y, Li J, Jiang Y et al (1992) A clinical study of photodynamic therapy for port wine stain-a report of 40 cases. Chinese J Laser Med (01):6–10. https://doi.org/10.13480/j.issn1003-9430.1992.01.003
doi: 10.13480/j.issn1003-9430.1992.01.003
Zhang B, Zhang T-H, Huang Z et al (2014) Comparison of pulsed dye laser (PDL) and photodynamic therapy (PDT) for treatment of facial port-wine stain (PWS) birthmarks in pediatric patients. Photodiagn Photodyn Ther 11(4):491–497. https://doi.org/10.1016/j.pdpdt.2014.06.004
doi: 10.1016/j.pdpdt.2014.06.004
Zhang M, Wu Q, Lin T et al (2020) Hematoporphyrin monomethyl ether photodynamic therapy for the treatment of facial port-wine stains resistant to pulsed dye laser. Photodiagn Photodyn Ther 31:101820. https://doi.org/10.1016/j.pdpdt.2020.101820
doi: 10.1016/j.pdpdt.2020.101820
Zhang L-C, Yang J, Huang Y-B et al (2022) Efficacy of hemoporfin photodynamic therapy for pulsed dye laser-resistant facial port-wine stains in 107 children: a retrospective study. Indian J Dermatol Venereol Leprol 88(2):275. https://doi.org/10.25259/IJDVL_976_20
doi: 10.25259/IJDVL_976_20
pubmed: 34672476
Khalaf AT, Sun Y, Wang F et al (2020) Photodynamic therapy using HMME for port-wine stains: clinical effectiveness and sonographic appearance. Biomed Res Int 2020:6030581. https://doi.org/10.1155/2020/6030581
doi: 10.1155/2020/6030581
pubmed: 32802859
pmcid: 7414368
Savas JA, Ledon JA, Franca K et al (2013) Pulsed dye laser-resistant port-wine stains: mechanisms of resistance and implications for treatment. Brit J Dermatol 168(5):941–953. https://doi.org/10.1111/bjd.12204
doi: 10.1111/bjd.12204
Zhang X-Y, Al-Odaini N, Fan R-G et al (2022) The efficacy of hematoporphyrin monomethyl ether photodynamic therapy in adult patients with port-wine stains: a retrospective study. Dermatol Ther 12(4):861–869. https://doi.org/10.1007/s13555-022-00699-w
doi: 10.1007/s13555-022-00699-w
Han Y, Yu W, Wang L et al (2022) Histological characteristics of port-wine stains with complete regression after photodynamic therapy treatment: a 7-year follow-up. Photobiomodul Photomed Laser Surg 40(3):159–162. https://doi.org/10.1089/photob.2021.0111
doi: 10.1089/photob.2021.0111
pubmed: 35298284
Liu L, Zhou L, Zhao Q et al (2022) Histological analysis of different types of port-wine stains to guide clinical decision making: a retrospective study. Indian J Dermatol Venereol Leprol:1–9. https://doi.org/10.25259/IJDVL_730_2021
Lin Y, Gong W, Kang J et al (2022) Hemoporfin-mediated photodynamic therapy for port-wine stains: multivariate analysis of clinical efficacy and optical coherence tomography appearance. Front Med 9:9. https://doi.org/10.3389/fmed.2022.800836
doi: 10.3389/fmed.2022.800836
Zhang X-Y, Al-Odaini N, Zheng W-J et al (2022) The relationship between the effectiveness of HMME-PDT and the dermoscopic features of port-wine stains in Chinese pediatric patients: a retrospective study. Dermatol Ther 12(7):1671–1683. https://doi.org/10.1007/s13555-022-00757-3
doi: 10.1007/s13555-022-00757-3
Xiao Q, Li Q, Yuan KH et al (2011) Photodynamic therapy of port-wine stains: long-term efficacy and complication in Chinese patients. J Dermatol 38(12):1146–1152. https://doi.org/10.1111/j.1346-8138.2011.01292.x
doi: 10.1111/j.1346-8138.2011.01292.x
pubmed: 22032688
Yu W, Ma G, Qiu Y et al (2016) Why do port-wine stains (PWS) on the lateral face respond better to pulsed dye laser (PDL) than those located on the central face? J Am Acad Dermatol 74(3):527–535. https://doi.org/10.1016/j.jaad.2015.08.026
doi: 10.1016/j.jaad.2015.08.026
pubmed: 26892654
Walker EP, Butler PH, Pickering JW et al (1989) Histology of port wine stains after copper vapour laser treatment. Brit J Dermatol 121(2):217–223. https://doi.org/10.1111/j.1365-2133.1989.tb01801.x
doi: 10.1111/j.1365-2133.1989.tb01801.x
Kelly KM, Kimel S, Smith T et al (2004) Combined photodynamic and photothermal induced injury enhances damage to in vivo model blood vessels. Laser Surg Med 34(5):407–413. https://doi.org/10.1002/lsm.20041
doi: 10.1002/lsm.20041
Chun-Hua T, Li-Qiang G, Hua W et al (2021) Efficacy and safety of hemoporfin photodynamic therapy for port-wine stains in paediatric patients: a retrospective study of 439 cases at a single centre. Photodiagn Photodyn 36:102568. https://doi.org/10.1016/j.pdpdt.2021.102568
doi: 10.1016/j.pdpdt.2021.102568
Hu D et al (2022) Retrospective analysis of Hemoporfin-mediated photodynamic therapy in the treatment of naïve port-wine stains. Photodiagn Photodyn 39:103003. https://doi.org/10.1016/j.pdpdt.2022.103003
doi: 10.1016/j.pdpdt.2022.103003
Odaci E S B. Face embryology. http://emedicine.medscape.com/article/844962-overview . Accessed 27 March 2023
Tan W, Chernova M, Gao L et al (2014) Sustained activation of c-Jun N-terminal and extracellular signal-regulated kinases in port-wine stain blood vessels. J Am Acad Dermatol 71(5):964–968. https://doi.org/10.1016/j.jaad.2014.07.025
doi: 10.1016/j.jaad.2014.07.025
pubmed: 25135651
pmcid: 4250318
Shirley MD, Tang H, Gallione CJ et al (2013) Sturge–Weber syndrome and port-wine stains caused by somatic mutation in GNAQ. N Engl J Med 368(21):1971–1979. https://doi.org/10.1056/NEJMoa1213507
doi: 10.1056/NEJMoa1213507
pubmed: 23656586
pmcid: 3749068