ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription.

Animals DNA, Mitochondrial / genetics Caenorhabditis elegans Proteins / genetics Mitochondria / genetics Caenorhabditis elegans / metabolism Cyclic AMP Response Element-Binding Protein / genetics DNA Damage Mitochondrial Proteins / genetics

Journal

Nature cell biology
ISSN: 1476-4679
Titre abrégé: Nat Cell Biol
Pays: England
ID NLM: 100890575

Informations de publication

Date de publication:
08 2023
Historique:
received: 11 04 2023
accepted: 19 06 2023
medline: 14 8 2023
pubmed: 18 7 2023
entrez: 17 7 2023
Statut: ppublish

Résumé

The ability to balance conflicting functional demands is critical for ensuring organismal survival. The transcription and repair of the mitochondrial genome (mtDNA) requires separate enzymatic activities that can sterically compete

Identifiants

DOI: 10.1038/s41556-023-01192-y PMID: 37460695
pubmed: 37460695
doi: 10.1038/s41556-023-01192-y
pii: 10.1038/s41556-023-01192-y
doi:

Substances chimiques

DNA, Mitochondrial 0
Caenorhabditis elegans Proteins 0
Cyclic AMP Response Element-Binding Protein 0
Mitochondrial Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1111-1120

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Chuan-Yang Dai (CY)

Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
ORCID: 0000-0001-8768-6196

Chai Chee Ng (CC)

Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.

Grace Ching Ching Hung (GCC)

Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
ORCID: 0000-0002-9732-5535

Ina Kirmes (I)

Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.

Laetitia A Hughes (LA)

Harry Perkins Institute of Medical Research, QEII Medical Centre, The University of Western Australia, Nedlands, Western Australia, Australia.
ARC Centre of Excellence in Synthetic Biology, QEII Medical Centre, The University of Western Australia, Nedlands, Western Australia, Australia.
Telethon Kids Institute, Northern Entrance, Perth Children's Hospital, Nedlands, Western Australia, Australia.

Yunguang Du (Y)

Department of Molecular, Cell and Cancer Biology, UMass Chan Medical School, Worchester, MA, USA.

Christopher A Brosnan (CA)

Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.

Arnaud Ahier (A)

Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.

Anne Hahn (A)

Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.

Cole M Haynes (CM)

Department of Molecular, Cell and Cancer Biology, UMass Chan Medical School, Worchester, MA, USA.
ORCID: 0000-0003-2110-5648

Oliver Rackham (O)

Harry Perkins Institute of Medical Research, QEII Medical Centre, The University of Western Australia, Nedlands, Western Australia, Australia.
ARC Centre of Excellence in Synthetic Biology, QEII Medical Centre, The University of Western Australia, Nedlands, Western Australia, Australia.
Telethon Kids Institute, Northern Entrance, Perth Children's Hospital, Nedlands, Western Australia, Australia.
Curtin Medical School and Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia.

Aleksandra Filipovska (A)

Harry Perkins Institute of Medical Research, QEII Medical Centre, The University of Western Australia, Nedlands, Western Australia, Australia.
ARC Centre of Excellence in Synthetic Biology, QEII Medical Centre, The University of Western Australia, Nedlands, Western Australia, Australia.
Telethon Kids Institute, Northern Entrance, Perth Children's Hospital, Nedlands, Western Australia, Australia.
ORCID: 0000-0002-6998-8403

Steven Zuryn (S)

Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia. s.zuryn@uq.edu.au.
ORCID: 0000-0002-3551-6790

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › ATFS-1 counteracts mitochondrial DNA damage by...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN mitochondrial › ATFS-1 counteracts mitochondrial DNA damage by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'helminthes › Protéines de Caenorhabditis elegans › ATFS-1 counteracts mitochondrial DNA damage by...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › ATFS-1 counteracts mitochondrial DNA damage by...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › ATFS-1 counteracts mitochondrial DNA damage by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Protéine de liaison à l'élément de réponse à l'AMP cyclique › ATFS-1 counteracts mitochondrial DNA damage by...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › ATFS-1 counteracts mitochondrial DNA damage by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › ATFS-1 counteracts mitochondrial DNA damage by...