Evolutionary origin, population diversity, and diagnostics for a cryptic hybrid pathogen.

allodiploidy diagnostics long-read sequencing medical mycology pangenome pathogenicity secondary metabolism transcriptome

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
03 Jul 2023
Historique:
pubmed: 18 7 2023
medline: 18 7 2023
entrez: 18 7 2023
Statut: epublish

Résumé

Cryptic fungal pathogens pose significant identification and disease management challenges due to their morphological resemblance to known pathogenic species while harboring genetic and (often) infectionrelevant trait differences. The cryptic fungal pathogen

Identifiants

DOI: 10.1101/2023.07.03.547508 PMID: 37461539 PMC: PMC10350022
pubmed: 37461539
doi: 10.1101/2023.07.03.547508
pmc: PMC10350022
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI153356
Pays : United States

Déclaration de conflit d'intérêts

Conflict of Interest J.L.S. is a scientific advisor for WittGen Biotechnologies. J.L.S. is an advisor for ForensisGroup Incorporated. A.R. is a scientific consultant for LifeMine Therapeutics, Inc. G.H.G. is a scientific consultant for Innovation Pharmaceuticals Inc. The other authors declare no other competing interests.

Auteurs

Jacob L Steenwyk (JL)

Howards Hughes Medical Institute and the Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Vanderbilt University, Department of Biological Sciences, VU Station B #35-1634, Nashville, TN 37235, United States of America.
Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN 37235, USA.
ORCID: 0000-0002-8436-595X

Sonja Knowles (S)

Department of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.

Rafael W Bastos (RW)

Faculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
Department of Microbiology and Parasitology, Bioscience Center, Federal University of Rio Grande do Norte, Natal-RN, Brazil.

Charu Balamurugan (C)

Vanderbilt University, Department of Biological Sciences, VU Station B #35-1634, Nashville, TN 37235, United States of America.
Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN 37235, USA.

David Rinker (D)

Vanderbilt University, Department of Biological Sciences, VU Station B #35-1634, Nashville, TN 37235, United States of America.
Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN 37235, USA.

Matthew E Mead (ME)

Vanderbilt University, Department of Biological Sciences, VU Station B #35-1634, Nashville, TN 37235, United States of America.
Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN 37235, USA.
ORCID: 0000-0001-9195-7585

Christopher D Roberts (CD)

Department of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.

Huzefa A Raja (HA)

Department of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.

Yuanning Li (Y)

Institute of Marine Science and Technology, Shandong University, 72 Binhai Road, Qingdao 266237, China.

Ana Cristina Colabardini (AC)

Faculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.

Patrícia Alves de Castro (PA)

Faculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.

Thaila Fernanda Dos Reis (TF)

Faculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.

David Canóvas (D)

Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Seville, Spain.

Rafael Luperini Sanchez (RL)

Faculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.

Katrien Lagrou (K)

Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Department of Laboratory Medicine and National Reference Centre for Mycosis, University Hospitals Leuven, 3000 Leuven, Belgium.

Egídio Torrado (E)

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4715-495 Braga, Portugal; ICVS/3B's-PT Government Associate Laboratory, 4715-495 Braga, Portugal.
ORCID: 0000-0002-7462-8234

Fernando Rodrigues (F)

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4715-495 Braga, Portugal; ICVS/3B's-PT Government Associate Laboratory, 4715-495 Braga, Portugal.
ORCID: 0000-0001-8436-9398

Nicholas H Oberlies (NH)

Department of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.

Xiaofan Zhou (X)

Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou, China.

Gustavo H Goldman (GH)

Faculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
ORCID: 0000-0002-2986-350X

Antonis Rokas (A)

Vanderbilt University, Department of Biological Sciences, VU Station B #35-1634, Nashville, TN 37235, United States of America.
Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN 37235, USA.
ORCID: 0000-0002-7248-6551

Classifications MeSH