Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes.
Arginase inhibitory activity
Curcuma comosa
Guaiane sesquiterpenoids
Sesquiterpenoids
Journal
Journal of natural medicines
ISSN: 1861-0293
Titre abrégé: J Nat Med
Pays: Japan
ID NLM: 101518405
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
30
05
2023
accepted:
09
07
2023
medline:
31
8
2023
pubmed:
18
7
2023
entrez:
18
7
2023
Statut:
ppublish
Résumé
Arginases are bimanganese enzymes involved in many human illnesses, and thus are targets for disease treatments. The screening of traditional medicinal plants demonstrated that an ethanol extract of Curcuma comosa rhizomes showed significant human arginase I and II inhibitory activity, and further fractionation led to the isolation of three known guaiane sesquiterpenoids, alismoxide (1), 7α,10α-epoxyguaiane-4α,11-diol (2) and guaidiol (3). Tests of their inhibitory activities on human arginases I and II revealed that 1 exhibited selective and potent competitive inhibition for human arginase I (IC
Identifiants
pubmed: 37462864
doi: 10.1007/s11418-023-01731-9
pii: 10.1007/s11418-023-01731-9
doi:
Substances chimiques
guaiane
0
Arginase
EC 3.5.3.1
Sesquiterpenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
891-897Informations de copyright
© 2023. The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy.
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