Vascular risk factors and astrocytic marker for the glymphatic system activity.
Astrocyte
DTI-ALPS
Diffusion tensor imaging
GFAP
Glymphatic system
Journal
La Radiologia medica
ISSN: 1826-6983
Titre abrégé: Radiol Med
Pays: Italy
ID NLM: 0177625
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
03
03
2023
accepted:
29
06
2023
medline:
4
9
2023
pubmed:
18
7
2023
entrez:
18
7
2023
Statut:
ppublish
Résumé
Glymphatic system maintains brain fluid circulation via active transportation of astrocytic aquaporin-4 in perivascular space. The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) is an established method measuring perivascular glymphatic activity, but comprehensive investigations into its influential factors are lacking. Community-dwelling older adults underwent brain MRI scans, neuropsychiatric, and multi-domain assessments. Blood biomarker tests included glial fibrillary acidic protein (GFAP) for astrocyte injury. In 71 enrolled participants, the DTI-ALPS index was associated with modifiable factors, including lipid profile (high-density lipoprotein, r = 0.396; very-low-density lipoprotein, r = - 0.342), glucose intolerance (diabetes mellitus, standardized mean difference (SMD) = 0.7662; glycated hemoglobin, r = - 0.324), obesity (body mass index, r = - 0.295; waist, r = - 0.455), metabolic syndrome (SMD = - 0.6068), cigarette-smoking (SMD = - 0.6292), and renal clearance (creatinine, r = - 0.387; blood urea nitrogen, r = - 0.303). Unmodifiable associative factors of DTI-ALPS were age (r = - 0.434) and sex (SMD = 1.0769) (all p < 0.05). A correlation of DTI-ALPS and blood GFAP was noticed (r = - 0.201, one-tailed t-test for the assumption that astrocytic injury impaired glymphatic activity, p = 0.046). Their cognitive correlations diverged, domain-specific for DTI-ALPS (Facial Memory Test, r = 0.272, p = 0.022) but global cognition-related for blood GFAP (MoCA, r = - 0.264, p = 0.026; ADAS-cog, r = 0.304, p = 0.010). This correlation analysis revealed multiple modifiable and unmodifiable association factors to the glymphatic image marker. The DTI-ALPS index correlated with various metabolic factors that are known to increase the risk of vascular diseases such as atherosclerosis. Furthermore, the DTI-ALPS index was associated with renal indices, and this connection might be a link of water regulation between the two systems. In addition, the astrocytic biomarker, plasma GFAP, might be a potential marker of the glymphatic system; however, more research is needed to confirm its effectiveness.
Identifiants
pubmed: 37462887
doi: 10.1007/s11547-023-01675-w
pii: 10.1007/s11547-023-01675-w
pmc: PMC10474179
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1148-1161Subventions
Organisme : Chang Gung Memorial Hospital
ID : CRRPG2K0033
Organisme : Chang Gung Memorial Hospital
ID : CRRPG2K0023
Organisme : Chang Gung Memorial Hospital
ID : CRRPG2K0013
Organisme : Chang Gung Memorial Hospital
ID : CLRPG2J0011
Organisme : Chang Gung Memorial Hospital
ID : CLRPG2L0052
Organisme : Ministry of Science and Technology, Taiwan
ID : MOST 111-2321-B-A49-003
Organisme : Ministry of Science and Technology, Taiwan
ID : NSTC 112-2321-B-A49-008-
Organisme : Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital
ID : CLRPG3N0011
Informations de copyright
© 2023. The Author(s).
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