Disease risk and healthcare utilization among ancestrally diverse groups in the Los Angeles region.
Journal
Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
received:
12
07
2022
accepted:
30
05
2023
medline:
21
7
2023
pubmed:
19
7
2023
entrez:
18
7
2023
Statut:
ppublish
Résumé
An individual's disease risk is affected by the populations that they belong to, due to shared genetics and environmental factors. The study of fine-scale populations in clinical care is important for identifying and reducing health disparities and for developing personalized interventions. To assess patterns of clinical diagnoses and healthcare utilization by fine-scale populations, we leveraged genetic data and electronic medical records from 35,968 patients as part of the UCLA ATLAS Community Health Initiative. We defined clusters of individuals using identity by descent, a form of genetic relatedness that utilizes shared genomic segments arising due to a common ancestor. In total, we identified 376 clusters, including clusters with patients of Afro-Caribbean, Puerto Rican, Lebanese Christian, Iranian Jewish and Gujarati ancestry. Our analysis uncovered 1,218 significant associations between disease diagnoses and clusters and 124 significant associations with specialty visits. We also examined the distribution of pathogenic alleles and found 189 significant alleles at elevated frequency in particular clusters, including many that are not regularly included in population screening efforts. Overall, this work progresses the understanding of health in understudied communities and can provide the foundation for further study into health inequities.
Identifiants
pubmed: 37464048
doi: 10.1038/s41591-023-02425-1
pii: 10.1038/s41591-023-02425-1
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1845-1856Subventions
Organisme : NINDS NIH HHS
ID : F31 NS122538
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA227237
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029929
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH122688
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG009080
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL155024
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151152
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM142112
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG011715
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG002536
Pays : United States
Organisme : NIH HHS
ID : DP5 OD024579
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.
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