Quantification of Endocannabinoids in Human Plasma.

Humans Chromatography, Liquid / methods Endocannabinoids / chemistry Tandem Mass Spectrometry / methods Liquid-Liquid Extraction Chromatography, High Pressure Liquid / methods
2-Arachidonoylglycerol Endocannabinoids Liquid chromatography Liquid-liquid extraction N-arachidonoylethanolamine Plasma Tandem mass spectrometry

Journal

Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969

Informations de publication

Date de publication:
2023
Historique:
medline: 21 7 2023
pubmed: 19 7 2023
entrez: 18 7 2023
Statut: ppublish

Résumé

The determination of the concentration of endocannabinoids and related compounds in human plasma has become a matter of interest due to their implication in physiological processes and, thus, their possible relation with physiological conditions or illnesses. The analysis of these compounds though has to be carefully designed as they are found in very low concentrations, and some of them degrade easily once blood is collected. In this chapter, a simple method based on a liquid-liquid extraction and analysis by liquid chromatography tandem mass spectrometry (LC-MS/MS) is described to determine the concentration of eight of the most relevant endocannabinoids in plasma.

Identifiants

DOI: 10.1007/978-1-0716-3307-6_9 PMID: 37464166
pubmed: 37464166
doi: 10.1007/978-1-0716-3307-6_9
doi:

Substances chimiques

Endocannabinoids 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

107-126

Informations de copyright

© 2023. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Références

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Auteurs

Aitor Villate (A)

Department of Analytical Chemistry, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Basque Country, Spain. aitor.villate@ehu.eus.

Markel San Nicolas (M)

Department of Analytical Chemistry, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Basque Country, Spain.
Sovereign Fields S.L., 20006, San Sebastian, Basque Country, Spain.

Oier Aizpurua-Olaizola (O)

Sovereign Fields S.L., 20006, San Sebastian, Basque Country, Spain.

Maitane Olivares (M)

Department of Analytical Chemistry, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Basque Country, Spain.
Research Centre for Experimental Marine Biology and Biotechnology (PIE), University of the Basque Country (UPV/EHU), Plentzia, Basque Country, Spain.

Aresatz Usobiaga (A)

Department of Analytical Chemistry, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Basque Country, Spain.
Research Centre for Experimental Marine Biology and Biotechnology (PIE), University of the Basque Country (UPV/EHU), Plentzia, Basque Country, Spain.

Nestor Etxebarria (N)

Department of Analytical Chemistry, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Basque Country, Spain.
Research Centre for Experimental Marine Biology and Biotechnology (PIE), University of the Basque Country (UPV/EHU), Plentzia, Basque Country, Spain.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Quantification of Endocannabinoids in Human Plasma.
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Quantification of Endocannabinoids in Human Plasma.
questionsmedicales.fr › Lipides › Acides gras › Endocannabinoïdes › Quantification of Endocannabinoids in Human Plasma.
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Quantification of Endocannabinoids in Human Plasma.
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Fractionnement chimique › Extraction liquide-liquide › Quantification of Endocannabinoids in Human Plasma.
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Quantification of Endocannabinoids in Human Plasma.