Nonclinical evaluation of a Vitis vinifera extract towards a novel antiaging cosmetic ingredient.
active ingredient
antiaging
cell culture
claim substantiation
natural product
Journal
Journal of cosmetic dermatology
ISSN: 1473-2165
Titre abrégé: J Cosmet Dermatol
Pays: England
ID NLM: 101130964
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
28
04
2023
received:
23
09
2022
accepted:
22
05
2023
medline:
4
12
2023
pubmed:
19
7
2023
entrez:
19
7
2023
Statut:
ppublish
Résumé
Skin aging is regulated by multiple physiological processes, such as oxidative stress. Natural products have been considered as a promising source of antioxidant compounds. As a result, few innovative products on the market based on natural products tackle additional underlying mechanisms of skin aging. The present work reports the nonclinical evaluation of a novel extract from the skin of V. vinifera fruits (codified as ACH37 extract), with the aim of supporting its use as an antiaging cosmetic ingredient candidate in clinical trials. We employed enzymatic, phenotypic, and gene expression assays, both in vitro and ex vivo, to investigate the action of the ACH37 extract in different biological processes that could be related to skin aging mechanisms. The ACH37 extract was able to scavenge reactive oxygen species (DPPH, O The results indicated that the ACH37 extract acts on multiple targets commonly related to skin aging, being a promising antiaging active ingredient candidate to be further investigated in clinical trials.
Sections du résumé
BACKGROUND
BACKGROUND
Skin aging is regulated by multiple physiological processes, such as oxidative stress. Natural products have been considered as a promising source of antioxidant compounds. As a result, few innovative products on the market based on natural products tackle additional underlying mechanisms of skin aging.
AIMS
OBJECTIVE
The present work reports the nonclinical evaluation of a novel extract from the skin of V. vinifera fruits (codified as ACH37 extract), with the aim of supporting its use as an antiaging cosmetic ingredient candidate in clinical trials.
METHODS
METHODS
We employed enzymatic, phenotypic, and gene expression assays, both in vitro and ex vivo, to investigate the action of the ACH37 extract in different biological processes that could be related to skin aging mechanisms.
RESULTS
RESULTS
The ACH37 extract was able to scavenge reactive oxygen species (DPPH, O
CONCLUSION
CONCLUSIONS
The results indicated that the ACH37 extract acts on multiple targets commonly related to skin aging, being a promising antiaging active ingredient candidate to be further investigated in clinical trials.
Substances chimiques
Antioxidants
0
Plant Extracts
0
Cosmetics
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3445-3458Informations de copyright
© 2023 Aché Laboratórios Farmacêuticos SA. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.
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