Discovery of a Series of Indane-Containing NBTIs with Activity against Multidrug-Resistant Gram-Negative Pathogens.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
13 Jul 2023
13 Jul 2023
Historique:
received:
04
05
2023
accepted:
20
06
2023
pmc-release:
13
07
2024
medline:
19
7
2023
pubmed:
19
7
2023
entrez:
19
7
2023
Statut:
epublish
Résumé
The rise of multidrug-resistant (MDR) Gram-negative bacteria is a major global health problem necessitating the discovery of new classes of antibiotics. Novel bacterial topoisomerase inhibitors (NBTIs) target the clinically validated bacterial type II topoisomerases with a distinct binding site and mechanism of action to fluoroquinolone antibiotics, thus avoiding cross-resistance to this drug class. Here we report the discovery of a series of NBTIs incorporating a novel indane DNA binding moiety. X-ray cocrystal structures of compounds
Identifiants
pubmed: 37465290
doi: 10.1021/acsmedchemlett.3c00187
pmc: PMC10350941
doi:
Types de publication
Journal Article
Langues
eng
Pagination
993-998Informations de copyright
© 2023 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
ACS Infect Dis. 2015 Jan 9;1(1):4-41
pubmed: 27620144
J Med Chem. 2020 Jun 11;63(11):5664-5674
pubmed: 32027491
Antimicrob Agents Chemother. 2014 May;58(5):2657-64
pubmed: 24566174
Future Med Chem. 2018 Oct 1;10(19):2241-2244
pubmed: 30215281
Sci Rep. 2019 Mar 21;9(1):5013
pubmed: 30899034
J Med Chem. 2017 May 11;60(9):3776-3794
pubmed: 28406300
J Med Chem. 2022 May 12;65(9):6431-6440
pubmed: 35503563
Expert Rev Anti Infect Ther. 2013 Mar;11(3):297-308
pubmed: 23458769
ACS Infect Dis. 2019 Apr 12;5(4):570-581
pubmed: 30757898
Curr Opin Investig Drugs. 2009 Aug;10(8):804-10
pubmed: 19649925
Antimicrob Agents Chemother. 2008 Sep;52(9):3339-49
pubmed: 18625781
J Med Chem. 2019 Aug 22;62(16):7445-7472
pubmed: 31276392
Future Med Chem. 2016 Jun;8(10):1085-100
pubmed: 27285067
Curr Top Med Chem. 2014;14(1):130-51
pubmed: 24236722
Nature. 2010 Aug 19;466(7309):935-40
pubmed: 20686482
Clin Microbiol Rev. 2011 Jan;24(1):71-109
pubmed: 21233508
Ann N Y Acad Sci. 2019 Jan;1435(1):18-38
pubmed: 29446459
J Med Chem. 2020 Sep 10;63(17):9623-9649
pubmed: 32787097
Nat Rev Mol Cell Biol. 2002 Jun;3(6):430-40
pubmed: 12042765