Diselenide Covalent Allosteric Inhibitors of Glutaminase with Strong


Journal

ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073

Informations de publication

Date de publication:
13 Jul 2023
Historique:
received: 03 11 2022
accepted: 28 04 2023
pmc-release: 13 07 2024
medline: 19 7 2023
pubmed: 19 7 2023
entrez: 19 7 2023
Statut: epublish

Résumé

Allosteric glutaminase inhibitors demonstrate inhibition of glutamine-dependent cancer cells with low general drug toxicity, but have issues with efficacy

Identifiants

pubmed: 37465295
doi: 10.1021/acsmedchemlett.2c00470
pmc: PMC10351061
doi:

Types de publication

Journal Article

Langues

eng

Pagination

920-928

Informations de copyright

© 2023 American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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Auteurs

Wei Hou (W)

College of Pharmaceutical Science, Collaborative Innovation Center of Yangtza River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.

Zhao Chen (Z)

College of Pharmaceutical Science, Collaborative Innovation Center of Yangtza River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.

Chuqiao Pan (C)

College of Pharmaceutical Science, Collaborative Innovation Center of Yangtza River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.

Maowei Ni (M)

Center for Cancer Research, Zhejiang Cancer Hospital, Hangzhou 310022, China.

Haoqiang Ruan (H)

College of Pharmaceutical Science, Collaborative Innovation Center of Yangtza River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.

Jun Song (J)

College of Pharmaceutical Science, Collaborative Innovation Center of Yangtza River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.

Shiying Lu (S)

College of Pharmaceutical Science, Collaborative Innovation Center of Yangtza River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.

Aman Bhasin (A)

Amity School of Chemical Sciences, Amity University, Panjab, Sector 82A, Mohali-140306, India.

Benfang Helen Ruan (BH)

College of Pharmaceutical Science, Collaborative Innovation Center of Yangtza River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.

Classifications MeSH