Novel Phenylene Lipids That Are Positive Allosteric Modulators of Glycine Receptors and Inhibitors of Glycine Transporter 2.

Humans Glycine Plasma Membrane Transport Proteins / metabolism Receptors, Glycine Chronic Pain Caproates Glycine / pharmacology Amino Acids
analgesics dual action glycine glycine receptor glycine transporter lipids

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
02 08 2023
Historique:
medline: 3 8 2023
pubmed: 19 7 2023
entrez: 19 7 2023
Statut: ppublish

Résumé

Chronic pain is a complex condition that remains resistant to current therapeutics. We previously synthesized a series of

Identifiants

DOI: 10.1021/acschemneuro.3c00167 PMID: 37466545
pubmed: 37466545
doi: 10.1021/acschemneuro.3c00167
doi:

Substances chimiques

Glycine Plasma Membrane Transport Proteins 0
Receptors, Glycine 0
hexanoic acid 1F8SN134MX
Caproates 0
Glycine TE7660XO1C
Amino Acids 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2634-2647

Subventions

Organisme : NIDA NIH HHS
ID : R01 DA048879
Pays : United States

Auteurs

Casey I Gallagher (CI)

Molecular and Cellular Biomedicine Theme, School of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia.

Zachary J Frangos (ZJ)

Molecular and Cellular Biomedicine Theme, School of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia.
ORCID: 0000-0002-5499-4050

Diba Sheipouri (D)

Molecular and Cellular Biomedicine Theme, School of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia.

Susan Shimmon (S)

School of Mathematical and Physical Sciences, Faculty of Science, The University of Technology Sydney, Sydney, NSW 2007, Australia.

Meryem-Nur Duman (MN)

School of Mathematical and Physical Sciences, Faculty of Science, The University of Technology Sydney, Sydney, NSW 2007, Australia.

Srinivasan Jayakumar (S)

Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, 110 Eighth Street, Troy, New York 12180, United States.

Christopher L Cioffi (CL)

Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, 110 Eighth Street, Troy, New York 12180, United States.

Tristan Rawling (T)

School of Mathematical and Physical Sciences, Faculty of Science, The University of Technology Sydney, Sydney, NSW 2007, Australia.
ORCID: 0000-0002-6624-6586

Robert J Vandenberg (RJ)

Molecular and Cellular Biomedicine Theme, School of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia.
ORCID: 0000-0003-1523-4814

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Novel Phenylene Lipids That Are Positive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs de neurotransmetteurs › Transporteurs plasmiques de neurotransmetteurs › Transporteurs de la glycine › Novel Phenylene Lipids That Are Positive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteur de la glycine › Novel Phenylene Lipids That Are Positive...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Douleur chronique › Novel Phenylene Lipids That Are Positive...
questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Caproates › Novel Phenylene Lipids That Are Positive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Glycine › Novel Phenylene Lipids That Are Positive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Novel Phenylene Lipids That Are Positive...