Recent advances in the development of metal complexes as antibacterial agents with metal-specific modes of action.
Journal
Current opinion in microbiology
ISSN: 1879-0364
Titre abrégé: Curr Opin Microbiol
Pays: England
ID NLM: 9815056
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
24
03
2023
revised:
19
05
2023
accepted:
23
05
2023
medline:
18
9
2023
pubmed:
19
7
2023
entrez:
19
7
2023
Statut:
ppublish
Résumé
The mounting burden of antimicrobial resistance (AMR) is one of the most concerning threats to public health worldwide. With low economic incentives and a dwindling supply of new drugs in clinical pipelines, more innovative approaches to novel drug design and development are desperately required. Metal-based compounds are rapidly emerging as an alternative to organic drugs, as they have the ability to kill pathogens via metal-specific modes of action. We herein review recent advances in metal-based antibacterial agents, including metal complexes, metal ions and catalytic metallodrugs. The review concludes with a perspective on the rational design of metal-based antibiotics, and how we can exploit their unique properties to tackle AMR.
Identifiants
pubmed: 37467616
pii: S1369-5274(23)00084-X
doi: 10.1016/j.mib.2023.102347
pii:
doi:
Substances chimiques
Coordination Complexes
0
Anti-Bacterial Agents
0
Metals
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102347Subventions
Organisme : Cancer Research UK
ID : CC2215
Pays : United Kingdom
Organisme : Medical Research Council
ID : CC2215
Pays : United Kingdom
Organisme : Wellcome Trust
ID : CC2215
Pays : United Kingdom
Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no conflicts of interests, financial or otherwise.