CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma.
Humans
Adaptor Proteins, Signal Transducing
/ metabolism
Calcium-Calmodulin-Dependent Protein Kinase Type 2
/ metabolism
Cell Cycle Proteins
/ metabolism
DNA-Binding Proteins
/ metabolism
Glioma
/ genetics
M Phase Cell Cycle Checkpoints
Mad2 Proteins
/ genetics
Mitosis
Nuclear Proteins
/ metabolism
Spindle Apparatus
/ metabolism
Ubiquitin-Protein Ligases
/ metabolism
Journal
Cell death and differentiation
ISSN: 1476-5403
Titre abrégé: Cell Death Differ
Pays: England
ID NLM: 9437445
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
04
04
2023
accepted:
12
07
2023
revised:
04
07
2023
medline:
9
8
2023
pubmed:
20
7
2023
entrez:
19
7
2023
Statut:
ppublish
Résumé
MAD2 is a spindle assembly checkpoint protein that participates in the formation of mitotic checkpoint complex, which blocks mitotic progression. RNF8, an established DNA damage response protein, has been implicated in mitotic checkpoint regulation but its exact role remains poorly understood. Here, RNF8 proximity proteomics uncovered a role of RNF8-MAD2 in generating the mitotic checkpoint signal. Specifically, RNF8 competes with a small pool of p31
Identifiants
pubmed: 37468549
doi: 10.1038/s41418-023-01192-3
pii: 10.1038/s41418-023-01192-3
pmc: PMC10406836
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Calcium-Calmodulin-Dependent Protein Kinase Type 2
EC 2.7.11.17
CAMK2D protein, human
EC 2.7.11.17
Cell Cycle Proteins
0
DNA-Binding Proteins
0
Mad2 Proteins
0
Nuclear Proteins
0
RNF8 protein, human
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
MAD2L1 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1973-1987Informations de copyright
© 2023. The Author(s).
Références
Am J Physiol Cell Physiol. 2004 Jun;286(6):C1238-45
pubmed: 14761894
Cell. 2011 Sep 2;146(5):732-45
pubmed: 21884935
Mol Cell. 2016 Sep 15;63(6):1021-33
pubmed: 27618486
Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11725-11730
pubmed: 31118282
J Cell Sci. 2011 Nov 15;124(Pt 22):3905-16
pubmed: 22100920
Cell Rep. 2021 Oct 19;37(3):109854
pubmed: 34686341
Oncotarget. 2018 Jan 08;9(12):10497-10509
pubmed: 29535822
Mol Cancer Res. 2020 Nov;18(11):1638-1649
pubmed: 32753472
Proc Natl Acad Sci U S A. 2011 May 17;108(20):8299-304
pubmed: 21525408
Nat Struct Mol Biol. 2011 Nov 20;18(12):1400-7
pubmed: 22101936
Nat Rev Cancer. 2022 Sep;22(9):497-514
pubmed: 35710946
Stem Cells. 2012 Jun;30(6):1064-75
pubmed: 22415968
Nat Methods. 2021 Feb;18(2):133-143
pubmed: 33432242
Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6418-23
pubmed: 17404223
J Clin Invest. 2018 Oct 1;128(10):4525-4542
pubmed: 30222135
Cancers (Basel). 2021 Oct 12;13(20):
pubmed: 34680264
J Control Release. 2021 Jan 10;329:1139-1149
pubmed: 33131697
EMBO J. 2006 Mar 22;25(6):1273-84
pubmed: 16525508
Sci Adv. 2021 Sep 03;7(36):eabf6033
pubmed: 34516894
Nat Commun. 2018 Oct 19;9(1):4354
pubmed: 30341343
EMBO Rep. 2012 Jun 01;13(6):515-27
pubmed: 22614003
Med Res Rev. 2016 Jul;36(4):749-86
pubmed: 27140825
Front Cell Dev Biol. 2021 Dec 13;9:700162
pubmed: 34966733
Biochem Biophys Res Commun. 2017 Jun 17;488(1):189-195
pubmed: 28499869
Nature. 2015 Nov 19;527(7578):389-93
pubmed: 26503038
Cell. 2007 Nov 30;131(5):901-14
pubmed: 18001825
Cold Spring Harb Perspect Biol. 2020 Jun 1;12(6):
pubmed: 31653643
Cell Signal. 2014 Apr;26(4):748-56
pubmed: 24407174
J Biol Chem. 1988 Dec 5;263(34):18145-51
pubmed: 2848027
FEBS Lett. 2021 Feb;595(4):491-506
pubmed: 33421097
J Biol Chem. 2014 Mar 21;289(12):8182-93
pubmed: 24509855
Science. 2014 Apr 11;344(6180):189-93
pubmed: 24652939
Cell. 2017 Nov 30;171(6):1437-1452.e17
pubmed: 29195078
Dev Cell. 2007 Feb;12(2):247-60
pubmed: 17276342
Stem Cell Res. 2014 Jul;13(1):135-43
pubmed: 24879067
Cell. 2007 Nov 16;131(4):744-55
pubmed: 18022368
Oncogene. 2008 Feb 28;27(10):1355-65
pubmed: 17724460
Genes Dev. 2008 Nov 1;22(21):2926-31
pubmed: 18981471
Nature. 2001 Jun 14;411(6839):801-5
pubmed: 11459059
Cell Cycle. 2019 Jan;18(1):7-15
pubmed: 30601084
Mol Cancer Ther. 2018 Dec;17(12):2551-2563
pubmed: 30217967
Front Cell Dev Biol. 2021 Mar 11;9:644630
pubmed: 33777949
Cell. 2012 Sep 14;150(6):1182-95
pubmed: 22980979
EMBO J. 2023 Feb 15;42(4):e111549
pubmed: 36598329
Nat Rev Cancer. 2008 May;8(5):361-75
pubmed: 18432251
Mol Biol Cell. 2011 Nov;22(22):4236-46
pubmed: 21965286
Cancer Discov. 2016 May;6(5):532-45
pubmed: 27001151
Semin Cell Dev Biol. 2021 Sep;117:86-98
pubmed: 34210579
Cell. 2007 Nov 30;131(5):887-900
pubmed: 18001824
Cancer Discov. 2013 Feb;3(2):198-211
pubmed: 23154965
Cell. 2009 Feb 6;136(3):435-46
pubmed: 19203579
Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20759-63
pubmed: 18077395
Genes Dev. 2019 Jun 1;33(11-12):591-609
pubmed: 31160393
Colloids Surf B Biointerfaces. 2013 Dec 1;112:350-5
pubmed: 24012704
J Exp Med. 2017 Jun 5;214(6):1843-1855
pubmed: 28507061
FEBS Lett. 1994 Jun 20;347(1):1-4
pubmed: 8013652
EMBO J. 2017 Feb 15;36(4):503-519
pubmed: 27993934
Front Pharmacol. 2014 Feb 11;5:15
pubmed: 24575042
Nat Commun. 2017 Nov 2;8(1):1271
pubmed: 29097665
Cell Death Differ. 2022 Jul;29(7):1379-1394
pubmed: 35058574
Dev Cell. 2014 Feb 10;28(3):282-94
pubmed: 24462187
Cell. 2007 Nov 16;131(4):730-43
pubmed: 18022367
Nat Rev Neurosci. 2022 Nov;23(11):666-682
pubmed: 36056211
Cell Cycle. 2011 Nov 1;10(21):3740-50
pubmed: 22037211
J Am Chem Soc. 2003 Feb 19;125(7):1731-7
pubmed: 12580598
Mol Cell. 2014 Jan 9;53(1):75-87
pubmed: 24316223
Cell. 2010 Feb 19;140(4):567-78
pubmed: 20178748
Science. 2006 Sep 29;313(5795):1929-35
pubmed: 17008526