KRAS(G12D) drives lepidic adenocarcinoma through stem-cell reprogramming.

Humans Adenocarcinoma of Lung / genetics Cellular Reprogramming / genetics Lung Neoplasms / genetics Proto-Oncogene Proteins p21(ras) / genetics Stem Cells / metabolism Extracellular Signal-Regulated MAP Kinases / metabolism

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
Jul 2023
Historique:
received: 18 09 2022
accepted: 14 06 2023
medline: 28 7 2023
pubmed: 20 7 2023
entrez: 19 7 2023
Statut: ppublish

Résumé

Many cancers originate from stem or progenitor cells hijacked by somatic mutations that drive replication, exemplified by adenomatous transformation of pulmonary alveolar epithelial type II (AT2) cells

Identifiants

DOI: 10.1038/s41586-023-06324-w PMID: 37468622 PMC: PMC10423036
pubmed: 37468622
doi: 10.1038/s41586-023-06324-w
pii: 10.1038/s41586-023-06324-w
pmc: PMC10423036
mid: NIHMS1919836
doi:

Substances chimiques

KRAS protein, human 0
Proto-Oncogene Proteins p21(ras) EC 3.6.5.2
Extracellular Signal-Regulated MAP Kinases EC 2.7.11.24

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

860-867

Subventions

Organisme : NHLBI NIH HHS
ID : F32 HL147417
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142549
Pays : United States
Organisme : NIH HHS
ID : S10 OD028536
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL129970
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL167410
Pays : United States
Organisme : NHLBI NIH HHS
ID : UG3 HL145623
Pays : United States
Organisme : NHLBI NIH HHS
ID : L30 HL143641
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Nicholas H Juul (NH)

Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Jung-Ki Yoon (JK)

Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0003-4947-1412

Marina C Martinez (MC)

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Neha Rishi (N)

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Yana I Kazadaeva (YI)

Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Maurizio Morri (M)

Chan-Zuckerberg Biohub, Stanford, CA, USA.

Norma F Neff (NF)

Chan-Zuckerberg Biohub, Stanford, CA, USA.

Winston L Trope (WL)

Division of Thoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.

Joseph B Shrager (JB)

Division of Thoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0003-0859-0589

Rahul Sinha (R)

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0001-7511-0798

Tushar J Desai (TJ)

Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. tdesai@stanford.edu.
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. tdesai@stanford.edu.
ORCID: 0000-0002-8794-5319

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › KRAS(G12D) drives lepidic adenocarcinoma...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs du thorax › Adénocarcinome pulmonaire › KRAS(G12D) drives lepidic adenocarcinoma...
questionsmedicales.fr › Phénomènes génétiques › Reprogrammation cellulaire › KRAS(G12D) drives lepidic adenocarcinoma...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › KRAS(G12D) drives lepidic adenocarcinoma...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes p21(ras) › KRAS(G12D) drives lepidic adenocarcinoma...
questionsmedicales.fr › Cellules › Cellules souches › KRAS(G12D) drives lepidic adenocarcinoma...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › Extracellular Signal-Regulated MAP Kinases › KRAS(G12D) drives lepidic adenocarcinoma...