Novel


Journal

ACS pharmacology & translational science
ISSN: 2575-9108
Titre abrégé: ACS Pharmacol Transl Sci
Pays: United States
ID NLM: 101721411

Informations de publication

Date de publication:
14 Jul 2023
Historique:
received: 17 05 2023
pmc-release: 03 07 2024
medline: 20 7 2023
pubmed: 20 7 2023
entrez: 20 7 2023
Statut: epublish

Résumé

Despite intensive efforts, no inhibitors of the Wnt/β-catenin signaling pathway have been approved so far for the clinical treatment of cancer. We synthesized novel

Identifiants

pubmed: 37470018
doi: 10.1021/acsptsci.3c00092
pmc: PMC10353061
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1087-1103

Informations de copyright

© 2023 The Authors. Published by American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

Références

J Med Chem. 2022 May 26;65(10):7246-7261
pubmed: 35581674
J Comput Aided Mol Des. 2013 Mar;27(3):221-34
pubmed: 23579614
J Med Chem. 2002 Jun 6;45(12):2615-23
pubmed: 12036371
J Comput Aided Mol Des. 2013 May;27(5):389-402
pubmed: 23737238
Science. 1997 Mar 21;275(5307):1787-90
pubmed: 9065402
Sci Rep. 2017 Mar 03;7:42717
pubmed: 28256516
Cell Rep. 2020 Feb 11;30(6):1735-1752.e7
pubmed: 32049007
Cell. 2012 Jun 8;149(6):1192-205
pubmed: 22682243
Molecules. 2021 Dec 09;26(24):
pubmed: 34946546
Lab Invest. 1995 Dec;73(6):922-6
pubmed: 8558855
J Clin Oncol. 2005 Oct 10;23(29):7350-60
pubmed: 16145060
Mol Med Rep. 2015 Mar;11(3):1566-72
pubmed: 25384676
Science. 1997 Mar 21;275(5307):1784-7
pubmed: 9065401
Cancer Discov. 2019 Feb;9(2):176-198
pubmed: 30679171
J Med Chem. 2011 Dec 22;54(24):8394-406
pubmed: 22044164
Oncotarget. 2017 May 16;8(20):33972-33989
pubmed: 28430641
ChemMedChem. 2021 May 6;16(9):1420-1424
pubmed: 33275320
Eur J Med Chem. 2018 Aug 5;156:554-562
pubmed: 30025349
Nat Rev Drug Discov. 2017 Aug;16(8):525-526
pubmed: 28529321
Anticancer Res. 2019 Dec;39(12):6575-6583
pubmed: 31810923
Oncogenesis. 2019 Nov 4;8(11):64
pubmed: 31685809
Hum Mutat. 1993;2(6):425-34
pubmed: 8111410
Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21
pubmed: 9757107
CA Cancer J Clin. 2022 Jan;72(1):7-33
pubmed: 35020204
Cancers (Basel). 2022 Mar 07;14(5):
pubmed: 35267666
Cell. 2012 Jun 8;149(6):1245-56
pubmed: 22682247
J Med Chem. 2023 Jan 12;66(1):1-31
pubmed: 36583662
Mol Cell. 2004 Aug 27;15(4):523-33
pubmed: 15327769
J Immunol Methods. 1991 Sep 13;142(2):257-65
pubmed: 1919029
Biotechniques. 1991 Nov;11(5):620-7
pubmed: 1804254
BMC Cancer. 2020 Oct 28;20(1):1038
pubmed: 33115416
Trends Biochem Sci. 2018 Aug;43(8):623-634
pubmed: 30056837
Cell Rep. 2016 Jun 28;16(1):28-36
pubmed: 27320923
ACS Chem Biol. 2013 Mar 15;8(3):524-9
pubmed: 23272635
Science. 2014 Oct 3;346(6205):1248012
pubmed: 25278615
Bioinformatics. 2020 May 1;36(9):2909-2911
pubmed: 31930403
Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):3-26
pubmed: 11259830
Heliyon. 2021 Apr 12;7(4):e06695
pubmed: 33912703
Oncol Lett. 2014 Aug;8(2):699-704
pubmed: 25013487
Signal Transduct Target Ther. 2020 Mar 20;5(1):22
pubmed: 32296018
J Med Chem. 2022 Nov 10;65(21):14261-14275
pubmed: 36282210
Methods Mol Biol. 2011;731:237-45
pubmed: 21516412
Clin Breast Cancer. 2009 Jun;9 Suppl 2:S73-81
pubmed: 19596646
ACS Med Chem Lett. 2019 Jan 14;10(4):499-503
pubmed: 30996786
Exp Biol Med (Maywood). 2017 Jun;242(11):1185-1197
pubmed: 28474989
BMC Cancer. 2018 Mar 9;18(1):272
pubmed: 29523110
Mol Cancer Ther. 2008 Mar;7(3):521-9
pubmed: 18347139
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21
pubmed: 20124702
Oncogene. 2018 Jun;37(24):3301-3316
pubmed: 29551770
Oncol Lett. 2017 Jul;14(1):441-446
pubmed: 28693189
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32
pubmed: 20124692
J Biol Chem. 1999 Jul 2;274(27):19115-23
pubmed: 10383415
ChemMedChem. 2020 Dec 3;15(23):2264-2268
pubmed: 32946182
Eur J Med Chem. 2015 May 5;95:277-301
pubmed: 25827398
J Hematol Oncol. 2020 Dec 4;13(1):165
pubmed: 33276800
J Biol Chem. 2003 Jun 6;278(23):21092-8
pubmed: 12657632

Auteurs

Marianna Nalli (M)

Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy.

Laura Di Magno (L)

Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine Sapienza, University of Rome, Viale Regina Elena 291, I-00161 Rome, Italy.

Yichao Wen (Y)

Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 365 South Xiangyang Road, 200031 Shanghai, China.

Xin Liu (X)

Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 200437 Shanghai, China.

Michele D'Ambrosio (M)

Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy.

Michela Puxeddu (M)

Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy.

Anastasia Parisi (A)

Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy.

Jessica Sebastiani (J)

Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy.

Andrea Sorato (A)

Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy.

Antonio Coluccia (A)

Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy.

Silvia Ripa (S)

Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine Sapienza, University of Rome, Viale Regina Elena 291, I-00161 Rome, Italy.

Fiorella Di Pastena (F)

Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine Sapienza, University of Rome, Viale Regina Elena 291, I-00161 Rome, Italy.

Davide Capelli (D)

CNR-Institute of Crystallography, Via Salaria-km 29.300, Monterotondo, 00015 Rome, Italy.

Roberta Montanari (R)

CNR-Institute of Crystallography, Via Salaria-km 29.300, Monterotondo, 00015 Rome, Italy.

Domiziana Masci (D)

Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Catholic University of the Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.

Andrea Urbani (A)

Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Catholic University of the Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.

Chiara Naro (C)

Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Catholic University of the Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.
GSTeP-Organoids Research Core Facility, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy.

Claudio Sette (C)

Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Catholic University of the Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.
GSTeP-Organoids Research Core Facility, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy.

Viviana Orlando (V)

Department of Biology and Biotechnologies "Charles Darwin", Piazzale Aldo Moro 5, I-00185 Roma, Italy.

Sara D'Angelo (S)

Department of Biology and Biotechnologies "Charles Darwin", Piazzale Aldo Moro 5, I-00185 Roma, Italy.

Stefano Biagioni (S)

Department of Biology and Biotechnologies "Charles Darwin", Piazzale Aldo Moro 5, I-00185 Roma, Italy.

Chiara Bigogno (C)

Aphad SrL, Via della Resistenza 65, 20090 Buccinasco, Italy.

Giulio Dondio (G)

Aphad SrL, Via della Resistenza 65, 20090 Buccinasco, Italy.

Arianna Pastore (A)

Department of Pharmacy, University of Naples "Federico II", Via Domenico Montesano, 49, 80131 Naples, Italy.

Mariano Stornaiuolo (M)

Department of Pharmacy, University of Naples "Federico II", Via Domenico Montesano, 49, 80131 Naples, Italy.

Gianluca Canettieri (G)

Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine Sapienza, University of Rome, Viale Regina Elena 291, I-00161 Rome, Italy.

Te Liu (T)

Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 365 South Xiangyang Road, 200031 Shanghai, China.

Romano Silvestri (R)

Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy.

Giuseppe La Regina (G)

Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy.

Classifications MeSH