Evaluation of portable gas chromatography-mass spectrometry (GC-MS) for the analysis of fentanyl, fentanyl analogs, and other synthetic opioids.
analog
fentanyl
field analysis
portable GC-MS
portable analysis
synthetic opioid
Journal
Journal of forensic sciences
ISSN: 1556-4029
Titre abrégé: J Forensic Sci
Pays: United States
ID NLM: 0375370
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
revised:
10
07
2023
received:
05
05
2023
accepted:
11
07
2023
medline:
6
9
2023
pubmed:
20
7
2023
entrez:
20
7
2023
Statut:
ppublish
Résumé
Potent synthetic opioids including fentanyl and its analogs are frequently encountered in the field and require detection and identification by first responders to maintain the safety of drug abusers, first responders, health-care providers, and the public at large. Due to the low concentration at which these substances may be encountered and the complicating matrices within which they may be dispersed, the use of portable gas chromatography-mass spectrometry (GC-MS) for their identification in the field offers great potential value. This research established that portable GC-MS is a useful method for the detection and identification of a large number of synthetic opioids, especially fentanyl and its analogs. In this study, 250 synthetic opioids and related substances including 210 fentanyl analogs were analyzed using portable GC-MS. It was concluded that 225 of the 250 (90.0%) opioids analyzed were successfully detected onboard at the time of analysis and identified as either the substance (55.2%) or an analog (34.8%). These outcomes have equivalent benefit for the field analysis of illicit drugs due to both initiating the same subsequent actions by first responders.
Identifiants
pubmed: 37470264
doi: 10.1111/1556-4029.15340
doi:
Substances chimiques
Analgesics, Opioid
0
Fentanyl
UF599785JZ
Illicit Drugs
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1601-1614Informations de copyright
© 2023 American Academy of Forensic Sciences.
Références
DEA Intelligence Program - Strategic Intelligence Section. Fentanyl flow to the United States. Washington, DC: United States Drug Enforcement Administration; 2020. Report No.: DEA-PRB-01-08-20-01.
New York State Department of Health. Addressing the opioid epidemic in New York State. https://www.health.ny.gov/community/opioid_epidemic/. Accessed 24 Mar 2023.
Saylor J. Heartland is not exempt from nationwide fentanyl epidemic. [Television News Report]. KTVO News: Iowa; 2023 https://ktvo.com/news/local/heartland-is-not-exempt-from-nationwide-fentanyl-epidemic. Accessed 24 Mar 2023.
Fargason PR. Senate criminal justice committee favors measures to fight Florida's opioid epidemic. The Florida Bar News. 15 Feb 2023. https://www.floridabar.org/the-florida-bar-news/senate-criminal-justice-committee-favors-measures-to-fight-floridas-opioid-epidemic/. Accessed 24 Mar 2023.
Office of the Attorney General of the State of Kentucky. Tacking the drug epidemic. https://www.ag.ky.gov/Priorities/Tackling-the-Drug-Epidemic/Pages/default.aspx. Accessed 24 Mar 2023.
May H, Julie K. Attacking the opioid crisis from all sides. https://uofuhealth.utah.edu/newsroom/news/2019/11/attack-opioid-crisis. Accessed 24 Mar 2023.
Oregon Department of Justice. Spotlight: Opioid abuse. https://www.doj.state.or.us/oregon-department-of-justice/office-of-the-attorney-general/spotlight-opioid-abuse/. Accessed 23 Mar 2023.
National Institute on Drug Abuse. Drug overdose death rates. https://nida.nih.gov/research-topics/trends-statistics/overdose-death-rates. Accessed 23 Mar 2023.
American Cancer Society. Opioids for cancer pain. https://www.cancer.org/cancer/managing-cancer/side-effects/pain/opioid-pain-medicines-for-cancer-pain.html. Accessed 23 Mar 2023.
Stanley T. The fentanyl story. J Pain. 2014;15(12):1215-1226. https://doi.org/10.1016/j.jpain.2014.08.010
Ahmad FB, Cisewski JA, Rossen LM, Sutton P. Provisional drug overdose death counts. https://www.cdc.gov/nchs/nvss/vsrr/drug-overdose-data.htm#notes. Accessed 23 Mar 2023.
Centers for Disease Control and Prevention. Fentanyl facts. https://www.cdc.gov/stopoverdose/fentanyl/index.html#:~:text=Powdered%20fentanyl%20looks%20just%20like,drugs%20are%20laced%20with%20fentanyl. Accessed 23 Mar 2023.
United States Drug Enforcement Administration. Facts about fentanyl. https://www.dea.gov/resources/facts-about-fentanyl. Accessed 26 Jan 2023.
Alyami H, Dahmash E, Bowen J, Mohammed AR. An investigation into the effects of excipient particle size, blending techniques and processing parameters on the homogeneity and content uniformity of a blend containing low-dose model drug. PLoS One. 2017;12(6):e0178772. https://doi.org/10.1371/journal.pone.0178772
Zheng JY. An overview. In: Zheng JY, editor. Formulation and analytical development for low-dose oral drug products. Hoboken, NJ: John Wiley & Sons, Inc.; 2009. p. 1-21.
United States Drug Enforcement Administration. Public service alert: DEA laboratory testing reveals that 6 out of 10 fentanyl-laced fake prescription pills now contain a potentially lethal dose of fentanyl. https://www.dea.gov/alert/dea-laboratory-testing-reveals-6-out-10-fentanyl-laced-fake-prescription-pills-now-contain. Accessed 23 Mar 2023.
O'Donnell J, Gladden M, Mattson CL, Kariisa M. Overdose deaths with carfentanil and other fentanyl analogs detected - 10 states, July 2016-June 2017. Morb Mortal Wkly Rep. 2018;67:767-768. https://doi.org/10.15585/mmwr.mm6727a4
Tennyson KM, Ray CS, Maass KT. Fentanyl and fentanyl analogues: federal trends and trafficking patterns. Washington, DC: United States Sentencing Commission; 2021.
de Bruin-Hoegée M, Kleiweg D, Noort D, van Asten AC. Chemical attribution of fentanyl: the effect of human metabolism. Forensic Chem. 2021;24:100330. https://doi.org/10.1016/j.forc.2021.100330
Erowid. Synthesis of fentanyl by Siegfried. https://www.erowid.org/archive/rhodium/chemistry/fentanyl.html. Accessed 28 Apr 2023.
Gupta PK, Ganesan K, Pande A, Malhotra RC. A convenient one pot synthesis of fentanyl. J Chem Res. 2005;2005:452-453. https://doi.org/10.3184/0308234057743090
Wilde M, Pichini S, Pacifici R, Tagliabracci A, Busardò FP, Auwärter V, et al. Metabolic pathways and potencies of new fentanyl analogs. Front Pharmacol. 2019;10:238. https://doi.org/10.3389/fphar.2019.00238
Norman C, Marland V, McKenzie C, Méncard H, Daéid N. Evaluation of fentanyl immunoassay test strips for rapid in-situ detection of fentanyl and fentanyl analogs in seized samples and alternative matrices. Int J Drug Policy. 2023;118:104102. https://doi.org/10.1016/j.drugpo.2023.104102
Angelini D, Biggs TD, Prugh AM, Smith JA, Hanburger JA, Llano B, et al. Detection of fentanyl and derivatives using a lateral flow immunoassay. Forensic Chem. 2021;23:100309. https://doi.org/10.1016/j.forc.2021.100309
Goldman JE, Waye KM, Periera KA, Krieger MS, Yedinak JL, Marshall BDL. Perspectives on rapid fentanyl tests strips as a harm reduction practice among young adults who use drugs: a qualitative study. Harm Reduct J. 2019;16(1):3. https://doi.org/10.1186/s12954-018-0276-0
Wharton RE, Casbohm J, Hoffmaster R, Brewer BN, Finn MG, Johnson CJ. Detection of 30 fentanyl analogs by commercial immunoassay kits. J Anal Toxicol. 2021;45(2):111-116. https://doi.org/10.1093/jat/bkaa181
McCrae K, Tobias S, Grant C, Lysyshyn M, Laing R, Wood E, et al. Assessing the limit of detection of Fourier-transform infrared spectroscopy and immunoassay strips for fentanyl in a real-world setting. Drug Alcohol Rev. 2020;39(1):98-102. https://doi.org/10.1111/dar.13004
Hauck BC, Riley PC, Ince BS. Effect of environmental conditions on the performance of fentanyl field detection tests. Forensic Chem. 2022;27:100394. https://doi.org/10.1016/j.forc.2021.100394
Ramsay M, Gozdzialski L, Larnder A, Wallace B, Hore D. Fentanyl quantification using portable infrared spectroscopy. A framework for community drug checking. Vib Spectrosc. 2021;114:103243. https://doi.org/10.1016/j.vibspec.2021.103243
Wilcox PG, Emmons ED, Pardoe IJ, Kline ND, Guicheteau JA. Quantitative Raman cross-sections and band assignments for fentanyl and fentanyl analogs. Appl Spectrosc. 2023;77(5):433-550. https://doi.org/10.1177/000370282311605
Smith M, Logan M, Bazley M, Blanchfield J, Stokes R, Blanco A, et al. A semi-quantitative method for the detection of fentanyl using surface-enhanced Raman scattering (SERS) with a handheld Raman instrument. J Forensic Sci. 2021;66(2):505-519. https://doi.org/10.1111/1556-4029.14610
Qin Y, Wang B, Wu Y, Wang J, Zong X, Yao W. Seed-mediated preparation of Ag@Au nanoparticles for highly sensitive surface-enhanced Raman detection of fentanyl. Crystals. 2021;11(7):769. https://doi.org/10.3390/cryst11070769
Wang H, Xue Z, Wu Y, Gilmore J, Wang L, Fabris L. Rapid SERS quantification of trace fentanyl laced in recreational drugs with a portable Raman module. Anal Chem. 2021;93:9373-9382. https://doi.org/10.1021/acs.analchem.1c00792
Fedick PW, Pu F, Morato NM, Cooks RG. Identification and confirmation of fentanyls on paper using portable surface enhanced Raman spectroscopy and paper spray ionization mass spectrometry. J Am Soc Mass Spectrom. 2021;31:735-741. https://doi.org/10.1021/jasms.0c00004
Sisco E, Verkouteren J, Staymates J, Lawrence J. Rapid detection of fentanyl, fentanyl analogues, and opioids for on-site or laboratory based drug seizures using thermal desorption DART-MS and ion mobility spectrometry. Forensic Chem. 2017;4:108-115. https://doi.org/10.1016/j.forc.2017.04.001
Forbes TP, Lawrence J, Verkouteren JR, Verkouteren RM. Discriminative potential of ion mobility spectrometry for the detection of fentanyl and fentanyl analogues relative to confounding environmental interferents. Analyst. 2019;144(21):6391-6403. https://doi.org/10.1039/C9an01771b
Fulton AC, Vaughan SR, DeGreeff LE. Non-contact detection of fentanyl by a field-portable ion mobility spectrometer. Drug Test Anal. 2022;14:1451-1459. https://doi.org/10.1002/dta.3272
Kern SE, Toomey VM, Lorenz LM. Rapid-field-deployable DART-MS screening technique for 87 opioids and drugs of abuse, including fentanyl and fentanyl analogs. J Regul Sci. 2022;10(2):1-14. https://doi.org/10.21423/JRS-V10I2KERN
Tilstone WJ, Savage KA, Clark LA. Forensic science: an encyclopedia of history, methods, and techniques. Santa Barbara, CA: ABC CLIO; 2006. p. 212.
Valdez CA. Gas chromatography-mass spectrometry analysis of synthetic opioids belonging to the fentanyl class: a review. Crit Rev Anal Chem. 2022;52(8):1938-1968. https://doi.org/10.1080/10408347.2021.1927668
Fiorentin TR, Logan BK, Martin DM, Browne T, Rieders EF. Assessment of portable quadrupole-based gas chromatography mass spectrometry for seized drug analysis. Forensic Sci Int. 2020;313:110342. https://doi.org/10.1016/j.forsciint.2020.110342
Gilbert N, Antonides LH, Schofield CJ, Costello A, Kilkelly B, Cain AR, et al. Hitting the jackpot - development of gas chromatography-mass spectrometry (GC-MS) and other rapid screening methods for the analysis of 18 fentanyl-derived synthetic opioids. Drug Test Anal. 2020;12(6):798-811. https://doi.org/10.1002/dta.2771
Gozdzialski L, Aasen J, Larnder A, Ramsay M, Borden SA, Saatchi A, et al. Portable gas chromatography-mass spectrometry in drug checking: detection of carfentanil and etizolam in expected opioid samples. Int J Drug Policy. 2021;97:103409. https://doi.org/10.1016/j.drugpo.2021.103409
Giltner A, Evans A, Cicco C, Leach S, Rowe W. Fentanyl analog trends in Washington D.C. observed in needle-exchange syringes. Forensic Sci Int. 2022;338:111393. https://doi.org/10.1016/j.forsciint.2022.111393
Crume C. History of INFICON HAPSITE: Maintenance management, support, and repair. http://www.kdanalytical.com/instruments/inficon-hapsite-history.aspx. Accessed 03 Jun 2018.
Leary PE, Kammrath BW, Lattman KJ, Beals GL. Deploying portable gas chromatography-mass spectrometry (GC-MS) to military users for the identification of toxic chemical agents in theater. Appl Spectrosc. 2019;73(8):841-858. https://doi.org/10.1177/0003702819849499
Hassanien SH, Bassman JR, Naccarato CMP, Twaraozynski JJ, Traynor JR, Iula DM, et al. In vitro pharmacology of fentanyl analogs at the human mu opioid receptor and their spectroscopic analysis. Drug Test Anal. 2020;12(8):1212-1221. https://doi.org/10.1002/dta.2822
United States Centers for Disease Control and Prevention. Traceable opioid material (TOM) kits. https://www.cdc.gov/nceh/dls/erb_fas_kits.html. Accessed 19 Apr 2023.
Cayman Chemical. Fentanyl analog screening kit booklet, item number 9003237. Ann Arbor, MI: Cayman Chemical; 2019. p. 4.
Cayman Chemical. Fentanyl analog screening kit booklet, emergent panel version 1, item number 9003286. Ann Arbor, MI: Cayman Chemical; 2019. p. 4-5.
Cayman Chemical. Fentanyl analog screening kit booklet, emergent panel version 2 and 3, item number 9003380. Ann Arbor, MI: Cayman Chemical; 2020. p. 4-5.
Cayman Chemical. Fentanyl analog screening kit, emergent panel version 4, item number 9003381. Ann Arbor, MI: Cayman Chemical; 2021. p. 4-5.
Teledyne FLIR. Griffin™ G510 person-portable GC-MS chemical identifier, technical data sheet. Elkridge, MD: Teledyne FLIR; 2021 Nov 10. Griffin G510_Datasheet-LTR 21-1110.
FLIR. FLIR Griffin™ G510e person-portable GC-MS chemical identifier focused on environmental applications. Arlington, VA: FLIR; 2021. 21-0317-DET-510e Datasheet_USL.
Mallard WG, Reed J. Automated mass spectral deconvolution & identification system, AMDIS - User guide. Gaithersburg, MD: National Institute of Standards and Technology (NIST); 1997.
de Hoffmann E, Stroobant V. Mass spectrometry: principles and applications. 3rd ed. West Sussex: John Wiley & Sons, Ltd; 2007.
National Institute of Standards and Technology. NIST chemistry webbook, SRD 69 - Propanamide, N-phenyl-. https://webbook.nist.gov/cgi/cbook.cgi?ID=C620713&Mask=200#Mass-Spec. Accessed 06 Jun 2023.
National Institute of Standards and Technology. NIST chemistry webbook, SRD 69 - Aniline. https://webbook.nist.gov/cgi/cbook.cgi?ID=C62533&Mask=200. Accessed 06 Jun 2023.
SciFinder - Chemical Abstracts Service. Spectrum ID CAS2017_MS_2_00024735. RN 67198-13-4. https://scifinder-n.cas.org/searchDetail/substance/644c2182b1a161166b04881b/substanceSpectra. Accessed 28 Apr 2023.